PE20120339A1 - Compuesto [5-(2-pirrolidin-1-il-etilsulfanil)-tiazol-2-il]-amida del acido -2-ciclohexil-1-(4-ciclopropanosulfonil-fenil)-ciclopropanocarboxilico como activador de glucoquinasa - Google Patents
Compuesto [5-(2-pirrolidin-1-il-etilsulfanil)-tiazol-2-il]-amida del acido -2-ciclohexil-1-(4-ciclopropanosulfonil-fenil)-ciclopropanocarboxilico como activador de glucoquinasaInfo
- Publication number
- PE20120339A1 PE20120339A1 PE2011001220A PE2011001220A PE20120339A1 PE 20120339 A1 PE20120339 A1 PE 20120339A1 PE 2011001220 A PE2011001220 A PE 2011001220A PE 2011001220 A PE2011001220 A PE 2011001220A PE 20120339 A1 PE20120339 A1 PE 20120339A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- cyclopropanosulfonyl
- ethylsulfanil
- tiazol
- pyrrolidin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 229940124828 glucokinase activator Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08380341 | 2008-12-19 | ||
| US15378109P | 2009-02-19 | 2009-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20120339A1 true PE20120339A1 (es) | 2012-04-16 |
Family
ID=40545955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011001220A PE20120339A1 (es) | 2008-12-19 | 2009-12-11 | Compuesto [5-(2-pirrolidin-1-il-etilsulfanil)-tiazol-2-il]-amida del acido -2-ciclohexil-1-(4-ciclopropanosulfonil-fenil)-ciclopropanocarboxilico como activador de glucoquinasa |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US8063079B2 (https=) |
| EP (1) | EP2379517B1 (https=) |
| JP (1) | JP5497064B2 (https=) |
| KR (1) | KR101290437B1 (https=) |
| CN (1) | CN102256952B (https=) |
| AR (1) | AR074470A1 (https=) |
| AU (1) | AU2009335931B2 (https=) |
| BR (1) | BRPI0923183B1 (https=) |
| CA (1) | CA2746746C (https=) |
| CO (1) | CO6382120A2 (https=) |
| CR (1) | CR20110342A (https=) |
| DK (1) | DK2379517T3 (https=) |
| DO (1) | DOP2011000197A (https=) |
| EA (1) | EA019055B1 (https=) |
| EC (1) | ECSP11011150A (https=) |
| ES (1) | ES2435242T3 (https=) |
| HR (1) | HRP20130983T1 (https=) |
| IL (1) | IL213210A (https=) |
| JO (1) | JO2979B1 (https=) |
| MA (1) | MA32902B1 (https=) |
| MX (1) | MX2011006434A (https=) |
| MY (1) | MY180567A (https=) |
| NZ (1) | NZ592930A (https=) |
| PA (1) | PA8851901A1 (https=) |
| PE (1) | PE20120339A1 (https=) |
| PL (1) | PL2379517T3 (https=) |
| PT (1) | PT2379517E (https=) |
| SG (1) | SG172256A1 (https=) |
| SI (1) | SI2379517T1 (https=) |
| TN (1) | TN2011000294A1 (https=) |
| TW (1) | TWI395748B (https=) |
| UA (1) | UA104742C2 (https=) |
| WO (1) | WO2010080333A1 (https=) |
| ZA (1) | ZA201103944B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102959076B (zh) | 2010-03-31 | 2015-09-16 | 斯克里普斯研究所 | 重编程细胞 |
| CN105899192B (zh) | 2013-11-22 | 2019-08-13 | 国立大学法人东京大学 | 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02010745A (es) | 2000-05-03 | 2003-03-10 | Hoffmann La Roche | Activadores de glucocinasa heteroaromaticos de alquinil-fenilo. |
| DK1282611T3 (da) | 2000-05-08 | 2005-02-14 | Hoffmann La Roche | Substituerede phenylacetatamider og anvendelse deraf som glucokinaseaktivatorer |
| WO2001085707A1 (en) | 2000-05-08 | 2001-11-15 | F. Hoffmann-La Roche Ag | Para-amine substituted phenylamide glucokinase activators |
| MY141521A (en) * | 2002-12-12 | 2010-05-14 | Hoffmann La Roche | 5-substituted-six-membered heteroaromatic glucokinase activators |
| DE60336850D1 (en) | 2003-01-06 | 2011-06-01 | Lilly Co Eli | Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| US7262196B2 (en) | 2003-02-11 | 2007-08-28 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
| US7432287B2 (en) * | 2003-02-26 | 2008-10-07 | Banyu Pharmeceutical Co., Ltd. | Heteroarylcarbamoylbenzene derivative |
| MXPA06012008A (es) | 2004-04-21 | 2007-01-25 | Prosidion Ltd | Compuestos de amida tri(ciclo) sustituidos. |
| KR100890695B1 (ko) | 2004-08-12 | 2009-03-26 | 프로시디온 리미티드 | 치환된 페닐아세트아미드 및 글루코키나제 활성화제로서의그의 용도 |
| EP1824835A1 (en) * | 2004-12-03 | 2007-08-29 | Novo Nordisk A/S | Heteroaromatic glucokinase activators |
| RU2008103142A (ru) * | 2005-07-01 | 2009-08-10 | Новартис АГ (CH) | Комбинация органических соединений |
| JP4033409B1 (ja) | 2005-07-11 | 2008-01-16 | 田辺三菱製薬株式会社 | オキシム誘導体及びその製法 |
| JP2009504621A (ja) * | 2005-08-09 | 2009-02-05 | アストラゼネカ アクチボラグ | 糖尿病の処置のためのヘテロアリールカルバモイルベンゼン誘導体 |
| WO2007051845A1 (en) | 2005-11-03 | 2007-05-10 | Prosidion Ltd | Tricyclo substituted amides |
| US20080293741A1 (en) * | 2005-11-03 | 2008-11-27 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides as Glucokinase Modulators |
| WO2007051846A1 (en) | 2005-11-03 | 2007-05-10 | Prosidion Ltd | Tricyclo substituted amides |
| KR20090025358A (ko) * | 2006-07-24 | 2009-03-10 | 에프. 호프만-라 로슈 아게 | 글루코키나제 활성화제로서의 피라졸 |
| EP2105435A4 (en) * | 2007-01-10 | 2011-06-15 | Mitsubishi Tanabe Pharma Corp | Hydrazone derivative |
| KR101608259B1 (ko) | 2008-04-28 | 2016-04-01 | 교린 세이야꾸 가부시키 가이샤 | 시클로펜틸아크릴산아미드 유도체 |
-
2009
- 2009-11-12 UA UAA201107562A patent/UA104742C2/uk unknown
- 2009-12-03 PA PA20098851901A patent/PA8851901A1/es unknown
- 2009-12-03 AR ARP090104672A patent/AR074470A1/es active IP Right Grant
- 2009-12-04 TW TW098141556A patent/TWI395748B/zh active
- 2009-12-06 JO JO2009467A patent/JO2979B1/en active
- 2009-12-11 MX MX2011006434A patent/MX2011006434A/es active IP Right Grant
- 2009-12-11 EA EA201170845A patent/EA019055B1/ru not_active IP Right Cessation
- 2009-12-11 KR KR1020117014073A patent/KR101290437B1/ko not_active Expired - Fee Related
- 2009-12-11 ES ES09768316T patent/ES2435242T3/es active Active
- 2009-12-11 PE PE2011001220A patent/PE20120339A1/es active IP Right Grant
- 2009-12-11 PL PL09768316T patent/PL2379517T3/pl unknown
- 2009-12-11 WO PCT/US2009/067603 patent/WO2010080333A1/en not_active Ceased
- 2009-12-11 BR BRPI0923183-8A patent/BRPI0923183B1/pt not_active IP Right Cessation
- 2009-12-11 NZ NZ592930A patent/NZ592930A/xx not_active IP Right Cessation
- 2009-12-11 CN CN200980150686XA patent/CN102256952B/zh active Active
- 2009-12-11 AU AU2009335931A patent/AU2009335931B2/en not_active Ceased
- 2009-12-11 SI SI200930713T patent/SI2379517T1/sl unknown
- 2009-12-11 PT PT97683163T patent/PT2379517E/pt unknown
- 2009-12-11 US US12/635,758 patent/US8063079B2/en active Active
- 2009-12-11 SG SG2011044823A patent/SG172256A1/en unknown
- 2009-12-11 HR HRP20130983AT patent/HRP20130983T1/hr unknown
- 2009-12-11 EP EP09768316.3A patent/EP2379517B1/en active Active
- 2009-12-11 MY MYPI2011002765A patent/MY180567A/en unknown
- 2009-12-11 DK DK09768316.3T patent/DK2379517T3/da active
- 2009-12-11 JP JP2011542276A patent/JP5497064B2/ja active Active
- 2009-12-11 CA CA2746746A patent/CA2746746C/en active Active
-
2011
- 2011-05-27 ZA ZA2011/03944A patent/ZA201103944B/en unknown
- 2011-05-30 IL IL213210A patent/IL213210A/en active IP Right Grant
- 2011-06-09 TN TN2011000294A patent/TN2011000294A1/fr unknown
- 2011-06-14 MA MA33945A patent/MA32902B1/fr unknown
- 2011-06-17 CR CR20110342A patent/CR20110342A/es unknown
- 2011-06-17 EC EC2011011150A patent/ECSP11011150A/es unknown
- 2011-06-17 DO DO2011000197A patent/DOP2011000197A/es unknown
- 2011-06-23 CO CO11079303A patent/CO6382120A2/es active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |