PE20120254A1 - Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(trifluorometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona - Google Patents
Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(trifluorometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-onaInfo
- Publication number
- PE20120254A1 PE20120254A1 PE2011001528A PE2011001528A PE20120254A1 PE 20120254 A1 PE20120254 A1 PE 20120254A1 PE 2011001528 A PE2011001528 A PE 2011001528A PE 2011001528 A PE2011001528 A PE 2011001528A PE 20120254 A1 PE20120254 A1 PE 20120254A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- etoximethyl
- trifluorometil
- decan
- ona
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
Abstract
REFERIDA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DE 5 MG A 200MG DE UNA SAL CRISTALINA DE MONOHIDRATO DE CLORHIDRATO DE LA (5S,8S)-8-[[(1R)-1-(3,5-BIS-TRIFLUOROMETIL)FENIL)-ETOXIMETIL]-8-FENIL-1,7-DIAZA-ESPIRO[4.5]DECAN-2-ONA, LACTOSA, CELULOSA MICROCRISTALINA, CROSCARMELOSA DE SODIO, ALMIDON PREGELATINIZADO Y ESTERARATO DE MAGNESIO, DONDE LA SAL PRESENTA UN PATRON DE DIFRACCION DE RAYOS X DE MUESTRAS EN POLVO EN 2 THETA CON LOS PICOS: 16,1, 18,4, 21,6 Y 23,5. DICHA COMPOSICION FARMACEUTICA ES UTIL EN EL TRATAMIENTO DE LAS NAUSEAS Y LA EMESIS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78951406P | 2006-04-05 | 2006-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120254A1 true PE20120254A1 (es) | 2012-03-26 |
Family
ID=38441502
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001528A PE20120254A1 (es) | 2006-04-05 | 2007-04-04 | Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(trifluorometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona |
PE2007000412A PE20080054A1 (es) | 2006-04-05 | 2007-04-04 | Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(triflourometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000412A PE20080054A1 (es) | 2006-04-05 | 2007-04-04 | Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(triflourometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona |
Country Status (20)
Country | Link |
---|---|
US (4) | US7563801B2 (es) |
EP (2) | EP2004148B1 (es) |
JP (4) | JP5155998B2 (es) |
KR (1) | KR20080108319A (es) |
CN (2) | CN101460151B (es) |
AR (1) | AR060303A1 (es) |
AU (1) | AU2007233389C1 (es) |
BR (1) | BRPI0710577A2 (es) |
CA (2) | CA2648640C (es) |
CL (1) | CL2007000945A1 (es) |
ES (1) | ES2553805T3 (es) |
HK (1) | HK1133387A1 (es) |
MX (1) | MX2008012936A (es) |
NO (1) | NO342810B1 (es) |
NZ (1) | NZ571693A (es) |
PE (2) | PE20120254A1 (es) |
SG (1) | SG10201500028RA (es) |
TW (1) | TWI332836B (es) |
WO (1) | WO2007114921A2 (es) |
ZA (1) | ZA200808465B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20030762A1 (es) | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
EP2004148B1 (en) * | 2006-04-05 | 2015-07-15 | OPKO Health, Inc. | Pharmaceutical formulations comprising salts of (5S,8S)-8-[{(1 R)-1-(3,5-Bis-trifluoromethyl)phenyl]- ethoxy}-methyl]-8-phenyl-1 ,7-diazaspiro[4.5]decan-2-one and their medical use |
ES2584838T3 (es) * | 2006-04-05 | 2016-09-29 | Opko Health, Inc | Sal clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decán-2-ona y procedimiento de preparación de la misma |
PE20081891A1 (es) | 2007-03-22 | 2008-12-27 | Opko Health Inc | Formulaciones de comprimidos que contienen sales de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-spiro[4.5]decan-2-ona y comprimidos elaborados a partir de estas |
AR066191A1 (es) * | 2007-03-22 | 2009-08-05 | Schering Corp | Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona |
JP5736313B2 (ja) | 2008-09-05 | 2015-06-17 | オプコ ヘルス, インコーポレイテッド | 8−[{1−(3,5−ビス−(トリフルオロメチル)フェニル)−エトキシ}−メチル]−8−フェニル−1,7−ジアザ−スピロ[4.5]デカン−2−オン化合物の合成のためのプロセスおよび中間体 |
EP2364138A2 (en) * | 2008-12-08 | 2011-09-14 | Teva Pharmaceutical Industries Ltd. | Palonosetron formulation |
CN105503870A (zh) * | 2009-08-14 | 2016-04-20 | 欧科生医股份有限公司 | 神经激肽-1拮抗剂的静脉内制剂 |
EP3002005A1 (en) * | 2014-09-30 | 2016-04-06 | Molkerei Meggle Wasserburg GmbH & Co. Kg | Direct compression excipient based on lactose, cellulose and starch |
CN104473887A (zh) * | 2014-11-12 | 2015-04-01 | 广东东阳光药业有限公司 | 一种提高利伐沙班片溶出曲线重现性的方法 |
CN106866669A (zh) * | 2017-04-19 | 2017-06-20 | 成都百特万合医药科技有限公司 | 一种合成罗拉吡坦中间体的方法 |
Family Cites Families (33)
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US431003A (en) * | 1890-06-24 | Store-service apparatus | ||
GB1605190A (en) * | 1968-08-23 | 1983-03-23 | Phillips Petroleum Co | Armour plate |
US4013613A (en) * | 1971-10-01 | 1977-03-22 | General Electric Company | Reinforced intercrystalline thermoplastic polyester compositions |
US4079161A (en) * | 1974-07-12 | 1978-03-14 | Phillips Petroleum Company | Transparent oriented polyolefin laminated armor structure |
FR2678971B1 (fr) * | 1991-07-08 | 1998-04-10 | Andre Giraud | Elements de structure composite transparents et leurs procedes de fabrication. |
US5830548A (en) * | 1992-08-11 | 1998-11-03 | E. Khashoggi Industries, Llc | Articles of manufacture and methods for manufacturing laminate structures including inorganically filled sheets |
US5665450A (en) * | 1992-08-21 | 1997-09-09 | The Curators Of The University Of Missouri | Optically transparent composite material and process for preparing same |
AU678409B2 (en) | 1992-10-28 | 1997-05-29 | Merck Sharp & Dohme Limited | 4-arylmethyloxymethyl piperidines as tachykinin antagonists |
AU682838B2 (en) | 1992-12-14 | 1997-10-23 | Merck Sharp & Dohme Limited | 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperidines as tachykinin receptor antagonists |
ATE170174T1 (de) | 1994-01-13 | 1998-09-15 | Merck Sharp & Dohme | Gem-bissubstituierte azazyclische tachykinin- antagonisten |
US5733659A (en) * | 1995-02-27 | 1998-03-31 | Mitsubishi Engineering-Plastics Corporation | Transparent rigid resin molded product and process for producing the same |
EP0812195B1 (en) * | 1995-02-28 | 2002-10-30 | Aventis Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol compounds |
EP0858341B1 (en) | 1995-08-28 | 2001-10-24 | Schering Corporation | Combination therapy for advanced cancer comprising temozolomide and cisplatin |
US5759658A (en) * | 1996-04-26 | 1998-06-02 | Tables International Corporation | Composite panels, articles incorporating same and method |
US5939098A (en) | 1996-09-19 | 1999-08-17 | Schering Corporation | Cancer treatment with temozolomide |
US6630231B2 (en) * | 1999-02-05 | 2003-10-07 | 3M Innovative Properties Company | Composite articles reinforced with highly oriented microfibers |
JP2002540148A (ja) * | 1999-03-30 | 2002-11-26 | シェーリング コーポレイション | テモゾロミドを用いる改善された癌処置 |
US6499984B1 (en) * | 2000-05-22 | 2002-12-31 | Warner-Lambert Company | Continuous production of pharmaceutical granulation |
DE10053151A1 (de) * | 2000-10-26 | 2002-05-08 | Bayer Ag | Zusammensetzung enthaltend thermoplastische Kunststoffe |
ATE374183T1 (de) | 2001-11-13 | 2007-10-15 | Schering Corp | Nk1-antagonisten |
PE20030762A1 (es) * | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
US6818306B2 (en) * | 2002-09-27 | 2004-11-16 | The Boeing Company | Optically clear structural laminate |
OA13266A (en) * | 2003-10-03 | 2007-01-31 | Pfizer | Imidazopyridine substituted tropane derivatives with CCR5 receptor antagonist activity for the treatment of HIV and inflammation. |
US6889938B1 (en) * | 2003-10-21 | 2005-05-10 | The Boeing Company | Structural cockpit window and method of making same |
JP2007515425A (ja) * | 2003-12-22 | 2007-06-14 | シェーリング コーポレイション | 医薬組成物 |
EP3269713A1 (en) | 2004-07-01 | 2018-01-17 | OPKO Health, Inc. | Piperidine derivatives as nk1 antagonists |
US20060100188A1 (en) | 2004-11-09 | 2006-05-11 | Chen Zong | Treatment methods |
ES2584838T3 (es) | 2006-04-05 | 2016-09-29 | Opko Health, Inc | Sal clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decán-2-ona y procedimiento de preparación de la misma |
EP2004148B1 (en) * | 2006-04-05 | 2015-07-15 | OPKO Health, Inc. | Pharmaceutical formulations comprising salts of (5S,8S)-8-[{(1 R)-1-(3,5-Bis-trifluoromethyl)phenyl]- ethoxy}-methyl]-8-phenyl-1 ,7-diazaspiro[4.5]decan-2-one and their medical use |
AR066191A1 (es) | 2007-03-22 | 2009-08-05 | Schering Corp | Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona |
PE20081891A1 (es) | 2007-03-22 | 2008-12-27 | Opko Health Inc | Formulaciones de comprimidos que contienen sales de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-spiro[4.5]decan-2-ona y comprimidos elaborados a partir de estas |
JP5736313B2 (ja) | 2008-09-05 | 2015-06-17 | オプコ ヘルス, インコーポレイテッド | 8−[{1−(3,5−ビス−(トリフルオロメチル)フェニル)−エトキシ}−メチル]−8−フェニル−1,7−ジアザ−スピロ[4.5]デカン−2−オン化合物の合成のためのプロセスおよび中間体 |
CN105503870A (zh) | 2009-08-14 | 2016-04-20 | 欧科生医股份有限公司 | 神经激肽-1拮抗剂的静脉内制剂 |
-
2007
- 2007-04-04 EP EP07774641.0A patent/EP2004148B1/en not_active Not-in-force
- 2007-04-04 JP JP2009504270A patent/JP5155998B2/ja not_active Expired - Fee Related
- 2007-04-04 ES ES07774641.0T patent/ES2553805T3/es active Active
- 2007-04-04 CN CN2007800206407A patent/CN101460151B/zh not_active Expired - Fee Related
- 2007-04-04 PE PE2011001528A patent/PE20120254A1/es not_active Application Discontinuation
- 2007-04-04 CN CN201310495198.0A patent/CN103751186B/zh not_active Expired - Fee Related
- 2007-04-04 AR ARP070101440A patent/AR060303A1/es unknown
- 2007-04-04 NZ NZ571693A patent/NZ571693A/en not_active IP Right Cessation
- 2007-04-04 KR KR1020087026488A patent/KR20080108319A/ko not_active Application Discontinuation
- 2007-04-04 CL CL2007000945A patent/CL2007000945A1/es unknown
- 2007-04-04 SG SG10201500028RA patent/SG10201500028RA/en unknown
- 2007-04-04 PE PE2007000412A patent/PE20080054A1/es active IP Right Grant
- 2007-04-04 BR BRPI0710577-0A patent/BRPI0710577A2/pt not_active Application Discontinuation
- 2007-04-04 WO PCT/US2007/008345 patent/WO2007114921A2/en active Application Filing
- 2007-04-04 US US11/732,663 patent/US7563801B2/en active Active
- 2007-04-04 CA CA2648640A patent/CA2648640C/en active Active
- 2007-04-04 TW TW096112177A patent/TWI332836B/zh not_active IP Right Cessation
- 2007-04-04 EP EP15176475.0A patent/EP2997964A1/en not_active Withdrawn
- 2007-04-04 MX MX2008012936A patent/MX2008012936A/es active IP Right Grant
- 2007-04-04 CA CA2861281A patent/CA2861281A1/en not_active Abandoned
- 2007-04-04 AU AU2007233389A patent/AU2007233389C1/en not_active Ceased
-
2008
- 2008-10-03 ZA ZA2008/08465A patent/ZA200808465B/en unknown
- 2008-11-04 NO NO20084660A patent/NO342810B1/no not_active IP Right Cessation
-
2009
- 2009-06-18 US US12/487,263 patent/US7981905B2/en active Active
- 2009-12-07 HK HK09111436.0A patent/HK1133387A1/xx not_active IP Right Cessation
-
2011
- 2011-07-18 US US13/184,926 patent/US8404702B2/en active Active
-
2012
- 2012-06-08 JP JP2012131109A patent/JP5415587B2/ja not_active Expired - Fee Related
- 2012-12-07 JP JP2012268500A patent/JP5640065B2/ja not_active Expired - Fee Related
-
2013
- 2013-03-19 US US13/847,242 patent/US9345692B2/en active Active
-
2014
- 2014-10-27 JP JP2014218278A patent/JP6035305B2/ja not_active Expired - Fee Related
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