PE20080054A1 - Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(triflourometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona - Google Patents

Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(triflourometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona

Info

Publication number
PE20080054A1
PE20080054A1 PE2007000412A PE2007000412A PE20080054A1 PE 20080054 A1 PE20080054 A1 PE 20080054A1 PE 2007000412 A PE2007000412 A PE 2007000412A PE 2007000412 A PE2007000412 A PE 2007000412A PE 20080054 A1 PE20080054 A1 PE 20080054A1
Authority
PE
Peru
Prior art keywords
phenyl
etoximethyl
decan
ona
diaza
Prior art date
Application number
PE2007000412A
Other languages
English (en)
Inventor
Zhihui Qui
Larisa Reyderman
Original Assignee
Opko Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38441502&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080054(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Opko Health Inc filed Critical Opko Health Inc
Publication of PE20080054A1 publication Critical patent/PE20080054A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REFERIDA A UNA FORMULACION FARMACEUTICA QUE CONTIENE UNA SAL CRISTALINA DE MONOHIDRATO DE HIDROCLORURO DE LA (5S,8S)-8-[[(1R)-1-(3,5-BIS-TRIFLUOROMETIL)-FENIL]-ETOXIMETIL]-8-FENIL-1,7-DIAZA-ESPIRO[4.5]DECAN-2-ONA, LACTOSA, CELULOSA MICROCRISTALINA, CROSCARMELOSA SODICA, ALMIDON PREGELATINIZADO Y ESTEARATO DE MAGNESIO. TAMBIEN ESTA REFERIDA A UNA CAPSULA QUE CONTIENE DICHA FORMULACION Y A UN PROCEDIMIENTO DE PREPARACION. LA FORMULACION ES UTIL EN EL TRATAMIENTO DE LA NAUSEA Y LA EMESIS
PE2007000412A 2006-04-05 2007-04-04 Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(triflourometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona PE20080054A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78951406P 2006-04-05 2006-04-05

Publications (1)

Publication Number Publication Date
PE20080054A1 true PE20080054A1 (es) 2008-02-25

Family

ID=38441502

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2007000412A PE20080054A1 (es) 2006-04-05 2007-04-04 Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(triflourometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona
PE2011001528A PE20120254A1 (es) 2006-04-05 2007-04-04 Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(trifluorometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2011001528A PE20120254A1 (es) 2006-04-05 2007-04-04 Formulaciones farmaceuticas de sales de 8-[1-(3,5-bis-(trifluorometil)fenil)-etoximetil]-8-fenil-1,7-diaza-espiro[4,5]decan-2-ona

Country Status (20)

Country Link
US (4) US7563801B2 (es)
EP (2) EP2997964A1 (es)
JP (4) JP5155998B2 (es)
KR (1) KR20080108319A (es)
CN (2) CN103751186B (es)
AR (1) AR060303A1 (es)
AU (1) AU2007233389C1 (es)
BR (1) BRPI0710577A2 (es)
CA (2) CA2861281A1 (es)
CL (1) CL2007000945A1 (es)
ES (1) ES2553805T3 (es)
HK (1) HK1133387A1 (es)
MX (1) MX2008012936A (es)
NO (1) NO342810B1 (es)
NZ (1) NZ571693A (es)
PE (2) PE20080054A1 (es)
SG (1) SG10201500028RA (es)
TW (1) TWI332836B (es)
WO (1) WO2007114921A2 (es)
ZA (1) ZA200808465B (es)

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PE20030762A1 (es) 2001-12-18 2003-09-05 Schering Corp Compuestos heterociclicos como antagonistas nk1
TWI332836B (en) * 2006-04-05 2010-11-11 Opko Health Inc Pharmaceutical formulations:salts of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and treatment methods using the same
ES2584838T3 (es) * 2006-04-05 2016-09-29 Opko Health, Inc Sal clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decán-2-ona y procedimiento de preparación de la misma
AR066191A1 (es) * 2007-03-22 2009-08-05 Schering Corp Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona
AR065802A1 (es) * 2007-03-22 2009-07-01 Schering Corp Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas
JP5736313B2 (ja) 2008-09-05 2015-06-17 オプコ ヘルス， インコーポレイテッド ８−［｛１−（３，５−ビス−（トリフルオロメチル）フェニル）−エトキシ｝−メチル］−８−フェニル−１，７−ジアザ−スピロ［４．５］デカン−２−オン化合物の合成のためのプロセスおよび中間体
US20100143461A1 (en) * 2008-12-08 2010-06-10 Ben-Zion Solomon Palonosetron formulation
WO2011019911A1 (en) * 2009-08-14 2011-02-17 Opko Health, Inc. Intravenous formulations of neurokinin-1 antagonists
EP3002005A1 (en) * 2014-09-30 2016-04-06 Molkerei Meggle Wasserburg GmbH & Co. Kg Direct compression excipient based on lactose, cellulose and starch
CN104473887A (zh) * 2014-11-12 2015-04-01 广东东阳光药业有限公司 一种提高利伐沙班片溶出曲线重现性的方法
CN106866669A (zh) * 2017-04-19 2017-06-20 成都百特万合医药科技有限公司 一种合成罗拉吡坦中间体的方法

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ES2584838T3 (es) 2006-04-05 2016-09-29 Opko Health, Inc Sal clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decán-2-ona y procedimiento de preparación de la misma
AR066191A1 (es) 2007-03-22 2009-08-05 Schering Corp Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona
AR065802A1 (es) 2007-03-22 2009-07-01 Schering Corp Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas
JP5736313B2 (ja) 2008-09-05 2015-06-17 オプコ ヘルス， インコーポレイテッド ８−［｛１−（３，５−ビス−（トリフルオロメチル）フェニル）−エトキシ｝−メチル］−８−フェニル−１，７−ジアザ−スピロ［４．５］デカン−２−オン化合物の合成のためのプロセスおよび中間体
WO2011019911A1 (en) 2009-08-14 2011-02-17 Opko Health, Inc. Intravenous formulations of neurokinin-1 antagonists

Also Published As

Publication number Publication date
EP2004148A2 (en) 2008-12-24
CN103751186A (zh) 2014-04-30
CA2648640C (en) 2016-02-16
NZ571693A (en) 2011-12-22
BRPI0710577A2 (pt) 2011-08-16
AU2007233389B2 (en) 2013-02-28
JP5415587B2 (ja) 2014-02-12
CN101460151A (zh) 2009-06-17
JP2013049720A (ja) 2013-03-14
ES2553805T3 (es) 2015-12-11
US7563801B2 (en) 2009-07-21
EP2997964A1 (en) 2016-03-23
TWI332836B (en) 2010-11-11
NO342810B1 (no) 2018-08-13
AU2007233389C1 (en) 2013-07-25
US7981905B2 (en) 2011-07-19
JP5155998B2 (ja) 2013-03-06
JP2009532473A (ja) 2009-09-10
NO20084660L (no) 2008-11-04
US8404702B2 (en) 2013-03-26
MX2008012936A (es) 2008-10-15
WO2007114921A3 (en) 2008-03-27
CN103751186B (zh) 2016-08-24
US20100137348A1 (en) 2010-06-03
CA2648640A1 (en) 2007-10-11
CL2007000945A1 (es) 2008-01-25
PE20120254A1 (es) 2012-03-26
WO2007114921A2 (en) 2007-10-11
US9345692B2 (en) 2016-05-24
TW200808312A (en) 2008-02-16
JP6035305B2 (ja) 2016-11-30
CA2861281A1 (en) 2007-10-11
AU2007233389A1 (en) 2007-10-11
HK1133387A1 (es) 2010-03-26
JP5640065B2 (ja) 2014-12-10
SG10201500028RA (en) 2015-02-27
ZA200808465B (en) 2011-03-30
AR060303A1 (es) 2008-06-04
US20070275051A1 (en) 2007-11-29
JP2012167125A (ja) 2012-09-06
CN101460151B (zh) 2013-11-20
JP2015071603A (ja) 2015-04-16
US20140088128A1 (en) 2014-03-27
KR20080108319A (ko) 2008-12-12
EP2004148B1 (en) 2015-07-15
US20120015921A1 (en) 2012-01-19

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