PE20110433A1 - Antagonistas de la via hedgehog de ftalazina disustituida - Google Patents

Antagonistas de la via hedgehog de ftalazina disustituida

Info

Publication number
PE20110433A1
PE20110433A1 PE2011000937A PE2011000937A PE20110433A1 PE 20110433 A1 PE20110433 A1 PE 20110433A1 PE 2011000937 A PE2011000937 A PE 2011000937A PE 2011000937 A PE2011000937 A PE 2011000937A PE 20110433 A1 PE20110433 A1 PE 20110433A1
Authority
PE
Peru
Prior art keywords
fluorophenyl
antagonists
disustituted
carboxamide hydrochloride
hedgehog pathway
Prior art date
Application number
PE2011000937A
Other languages
English (en)
Spanish (es)
Inventor
Jolie Anne Bastian
Philip Arthur Hipskind
Daniel Jon Sall
Takako Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110433(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20110433A1 publication Critical patent/PE20110433A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PE2011000937A 2008-11-03 2009-10-22 Antagonistas de la via hedgehog de ftalazina disustituida PE20110433A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11070308P 2008-11-03 2008-11-03

Publications (1)

Publication Number Publication Date
PE20110433A1 true PE20110433A1 (es) 2011-07-09

Family

ID=41566219

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000937A PE20110433A1 (es) 2008-11-03 2009-10-22 Antagonistas de la via hedgehog de ftalazina disustituida

Country Status (29)

Country Link
US (1) US8404687B2 (OSRAM)
EP (1) EP2364185B1 (OSRAM)
JP (1) JP2012507535A (OSRAM)
KR (1) KR101335746B1 (OSRAM)
CN (1) CN102202737B (OSRAM)
AU (1) AU2009320251C1 (OSRAM)
BR (1) BRPI0921437A2 (OSRAM)
CA (1) CA2742539C (OSRAM)
CL (1) CL2011000979A1 (OSRAM)
CO (1) CO6382123A2 (OSRAM)
CR (1) CR20110202A (OSRAM)
CY (1) CY1114023T1 (OSRAM)
DK (1) DK2364185T3 (OSRAM)
EA (1) EA018931B1 (OSRAM)
EC (1) ECSP11011021A (OSRAM)
ES (1) ES2418479T3 (OSRAM)
HR (1) HRP20130527T1 (OSRAM)
IL (1) IL211841A0 (OSRAM)
MA (1) MA32726B1 (OSRAM)
MX (1) MX2011004683A (OSRAM)
NZ (1) NZ591945A (OSRAM)
PE (1) PE20110433A1 (OSRAM)
PL (1) PL2364185T3 (OSRAM)
PT (1) PT2364185E (OSRAM)
SI (1) SI2364185T1 (OSRAM)
TN (1) TN2011000166A1 (OSRAM)
UA (1) UA102115C2 (OSRAM)
WO (1) WO2010062507A1 (OSRAM)
ZA (1) ZA201102448B (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20090188A1 (es) * 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
KR101335770B1 (ko) 2008-11-17 2013-12-12 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
EP2358698B1 (en) 2008-11-17 2012-09-05 Eli Lilly and Company Tetrasubstituted pyridazine as hedgehog pathway antagonists
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
US9814703B2 (en) 2013-11-14 2017-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of BMP signaling
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN116349204A (zh) 2020-10-13 2023-06-27 奋进生物医药公司 治疗纤维化的方法
WO2024064245A1 (en) * 2022-09-23 2024-03-28 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
US12447148B2 (en) 2024-03-05 2025-10-21 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
WO1998014431A1 (en) * 1996-10-01 1998-04-09 Kyowa Hakko Kogyo Co., Ltd. Nitrogenous heterocyclic compounds
ES2162235T3 (es) 1996-01-15 2001-12-16 Janssen Pharmaceutica Nv Piridazinaminas inhibidoras de la angiogenesis.
US6432970B2 (en) 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
WO1999052534A1 (en) 1998-04-09 1999-10-21 Johns Hopkins University School Of Medicine Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways
AU780358B2 (en) 1999-06-08 2005-03-17 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
ATE404200T1 (de) 2002-04-22 2008-08-15 Univ Johns Hopkins Med Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
AU2003265853A1 (en) 2002-08-29 2004-03-19 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
CA2564996A1 (en) 2004-05-08 2006-01-12 Taeyoung Yoon 3-aryl-5,6-disubstituted pyridazines
KR20160058972A (ko) * 2004-09-02 2016-05-25 제넨테크, 인크. 헤지호그 신호전달에 대한 피리딜 억제제
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
PE20090188A1 (es) 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
ES2505091T3 (es) 2007-06-25 2014-10-09 Amgen Inc. Compuestos, composiciones y métodos de uso de ftalazina
WO2009035568A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
EP2358698B1 (en) 2008-11-17 2012-09-05 Eli Lilly and Company Tetrasubstituted pyridazine as hedgehog pathway antagonists
KR101335770B1 (ko) 2008-11-17 2013-12-12 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
HK1159010A1 (en) 2012-07-27
PL2364185T3 (pl) 2013-10-31
SI2364185T1 (sl) 2013-07-31
US8404687B2 (en) 2013-03-26
EA201170640A1 (ru) 2011-12-30
ES2418479T3 (es) 2013-08-14
DK2364185T3 (da) 2013-06-03
CO6382123A2 (es) 2012-02-15
CA2742539C (en) 2014-05-06
AU2009320251A1 (en) 2010-06-03
ECSP11011021A (es) 2011-06-30
AU2009320251B2 (en) 2013-01-24
BRPI0921437A2 (pt) 2018-10-30
CN102202737B (zh) 2014-03-26
EA018931B1 (ru) 2013-11-29
HRP20130527T1 (en) 2013-07-31
US20110190304A1 (en) 2011-08-04
AU2009320251C1 (en) 2013-08-15
KR101335746B1 (ko) 2013-12-12
CN102202737A (zh) 2011-09-28
JP2012507535A (ja) 2012-03-29
IL211841A0 (en) 2011-06-30
EP2364185B1 (en) 2013-05-22
CY1114023T1 (el) 2016-07-27
CR20110202A (es) 2011-06-09
TN2011000166A1 (en) 2012-12-17
NZ591945A (en) 2012-10-26
MX2011004683A (es) 2011-06-20
PT2364185E (pt) 2013-07-24
WO2010062507A1 (en) 2010-06-03
UA102115C2 (ru) 2013-06-10
KR20110066212A (ko) 2011-06-16
CA2742539A1 (en) 2010-06-03
EP2364185A1 (en) 2011-09-14
ZA201102448B (en) 2012-09-26
CL2011000979A1 (es) 2011-10-07
MA32726B1 (fr) 2011-10-02

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