UA102115C2 - Дизамещенные фталазиновые антагонисты сигнального пути hedgehog - Google Patents

Дизамещенные фталазиновые антагонисты сигнального пути hedgehog

Info

Publication number
UA102115C2
UA102115C2 UAA201105364A UAA201105364A UA102115C2 UA 102115 C2 UA102115 C2 UA 102115C2 UA A201105364 A UAA201105364 A UA A201105364A UA A201105364 A UAA201105364 A UA A201105364A UA 102115 C2 UA102115 C2 UA 102115C2
Authority
UA
Ukraine
Prior art keywords
hedgehog pathway
pathway antagonists
disubstituted phthalazine
phthalazine hedgehog
disubstituted
Prior art date
Application number
UAA201105364A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Джоли Эн Бастиан
Филип Артур Хипскинд
Даниэль Джон Селл
Такако Уилсон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA102115(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of UA102115C2 publication Critical patent/UA102115C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
UAA201105364A 2008-11-03 2009-10-22 Дизамещенные фталазиновые антагонисты сигнального пути hedgehog UA102115C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11070308P 2008-11-03 2008-11-03
PCT/US2009/061573 WO2010062507A1 (en) 2008-11-03 2009-10-22 Disubstituted phthalazine hedgehog pathway antagonists

Publications (1)

Publication Number Publication Date
UA102115C2 true UA102115C2 (ru) 2013-06-10

Family

ID=41566219

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201105364A UA102115C2 (ru) 2008-11-03 2009-10-22 Дизамещенные фталазиновые антагонисты сигнального пути hedgehog

Country Status (29)

Country Link
US (1) US8404687B2 (OSRAM)
EP (1) EP2364185B1 (OSRAM)
JP (1) JP2012507535A (OSRAM)
KR (1) KR101335746B1 (OSRAM)
CN (1) CN102202737B (OSRAM)
AU (1) AU2009320251C1 (OSRAM)
BR (1) BRPI0921437A2 (OSRAM)
CA (1) CA2742539C (OSRAM)
CL (1) CL2011000979A1 (OSRAM)
CO (1) CO6382123A2 (OSRAM)
CR (1) CR20110202A (OSRAM)
CY (1) CY1114023T1 (OSRAM)
DK (1) DK2364185T3 (OSRAM)
EA (1) EA018931B1 (OSRAM)
EC (1) ECSP11011021A (OSRAM)
ES (1) ES2418479T3 (OSRAM)
HR (1) HRP20130527T1 (OSRAM)
IL (1) IL211841A0 (OSRAM)
MA (1) MA32726B1 (OSRAM)
MX (1) MX2011004683A (OSRAM)
NZ (1) NZ591945A (OSRAM)
PE (1) PE20110433A1 (OSRAM)
PL (1) PL2364185T3 (OSRAM)
PT (1) PT2364185E (OSRAM)
SI (1) SI2364185T1 (OSRAM)
TN (1) TN2011000166A1 (OSRAM)
UA (1) UA102115C2 (OSRAM)
WO (1) WO2010062507A1 (OSRAM)
ZA (1) ZA201102448B (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20090188A1 (es) * 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
KR101335770B1 (ko) 2008-11-17 2013-12-12 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
EP2358698B1 (en) 2008-11-17 2012-09-05 Eli Lilly and Company Tetrasubstituted pyridazine as hedgehog pathway antagonists
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
US9814703B2 (en) 2013-11-14 2017-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of BMP signaling
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
CN116349204A (zh) 2020-10-13 2023-06-27 奋进生物医药公司 治疗纤维化的方法
WO2024064245A1 (en) * 2022-09-23 2024-03-28 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
US12447148B2 (en) 2024-03-05 2025-10-21 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
WO1998014431A1 (en) * 1996-10-01 1998-04-09 Kyowa Hakko Kogyo Co., Ltd. Nitrogenous heterocyclic compounds
ES2162235T3 (es) 1996-01-15 2001-12-16 Janssen Pharmaceutica Nv Piridazinaminas inhibidoras de la angiogenesis.
US6432970B2 (en) 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
WO1999052534A1 (en) 1998-04-09 1999-10-21 Johns Hopkins University School Of Medicine Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways
AU780358B2 (en) 1999-06-08 2005-03-17 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
ATE404200T1 (de) 2002-04-22 2008-08-15 Univ Johns Hopkins Med Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
AU2003265853A1 (en) 2002-08-29 2004-03-19 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
WO2005033288A2 (en) * 2003-09-29 2005-04-14 The Johns Hopkins University Hedgehog pathway antagonists
TW200533356A (en) 2004-02-24 2005-10-16 Mitsubishi Pharma Corp Fused pyridazine derivatives
CA2564996A1 (en) 2004-05-08 2006-01-12 Taeyoung Yoon 3-aryl-5,6-disubstituted pyridazines
KR20160058972A (ko) * 2004-09-02 2016-05-25 제넨테크, 인크. 헤지호그 신호전달에 대한 피리딜 억제제
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
PE20090188A1 (es) 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
ES2505091T3 (es) 2007-06-25 2014-10-09 Amgen Inc. Compuestos, composiciones y métodos de uso de ftalazina
WO2009035568A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
UA102250C2 (ru) 2008-04-29 2013-06-25 Эли Лилли Энд Компани Двухзамещенные фталазины - антагонисты проводящего пути hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
EP2358698B1 (en) 2008-11-17 2012-09-05 Eli Lilly and Company Tetrasubstituted pyridazine as hedgehog pathway antagonists
KR101335770B1 (ko) 2008-11-17 2013-12-12 일라이 릴리 앤드 캄파니 사치환된 피리다진 헷지호그 경로 길항제
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
HK1159010A1 (en) 2012-07-27
PL2364185T3 (pl) 2013-10-31
SI2364185T1 (sl) 2013-07-31
US8404687B2 (en) 2013-03-26
EA201170640A1 (ru) 2011-12-30
ES2418479T3 (es) 2013-08-14
DK2364185T3 (da) 2013-06-03
CO6382123A2 (es) 2012-02-15
CA2742539C (en) 2014-05-06
AU2009320251A1 (en) 2010-06-03
ECSP11011021A (es) 2011-06-30
AU2009320251B2 (en) 2013-01-24
BRPI0921437A2 (pt) 2018-10-30
CN102202737B (zh) 2014-03-26
EA018931B1 (ru) 2013-11-29
HRP20130527T1 (en) 2013-07-31
US20110190304A1 (en) 2011-08-04
AU2009320251C1 (en) 2013-08-15
KR101335746B1 (ko) 2013-12-12
CN102202737A (zh) 2011-09-28
JP2012507535A (ja) 2012-03-29
IL211841A0 (en) 2011-06-30
EP2364185B1 (en) 2013-05-22
CY1114023T1 (el) 2016-07-27
PE20110433A1 (es) 2011-07-09
CR20110202A (es) 2011-06-09
TN2011000166A1 (en) 2012-12-17
NZ591945A (en) 2012-10-26
MX2011004683A (es) 2011-06-20
PT2364185E (pt) 2013-07-24
WO2010062507A1 (en) 2010-06-03
KR20110066212A (ko) 2011-06-16
CA2742539A1 (en) 2010-06-03
EP2364185A1 (en) 2011-09-14
ZA201102448B (en) 2012-09-26
CL2011000979A1 (es) 2011-10-07
MA32726B1 (fr) 2011-10-02

Similar Documents

Publication Publication Date Title
JO2931B1 (en) Double-substituted phthalazin compounds as antagonists of the cell-specific factor pathway
MY159491A (en) Disubstituted phthalazine hedgehog pathway antagonists
TN2011000166A1 (en) Disubstituted phthalazine hedgehog pathway antagonists
EA201171367A1 (ru) Винилиндазолильные соединения
MX2009012625A (es) Metodos para el tratamiento, diagnostico y deteccion de trastornos asociados con el fgf21.
MX2009008347A (es) Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso.
MX2009008222A (es) Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama.
JO2788B1 (en) Amido phenoxyendazole compounds beneficial as C-MET inhibitors
MY153915A (en) Organic compounds
TW201713640A (en) Bruton's tyrosine kinase inhibitors
MX2009008430A (es) Anticuerpos anti-robo4 y sus usos.
MX2010003117A (es) Compuestos y composiciones como moduladores de la actividad de gpr119.
MX2009009491A (es) Compuestos y composiciones como moduladores de la actividad del gpr119.
MY186456A (en) Quinazoline carboxamide azetidines
IN2012DN02471A (OSRAM)
EA200971068A1 (ru) Триазолиламинопиримидиновые соединения
MX2009011346A (es) Tapentadol para tratamiento de dolor con artritis.
EA201170700A1 (ru) Тетразамещенные пиридазины в качестве антагонистов пути hedgehog
MX2009009693A (es) Metodos para activar irs-1 y akt.
EA200971067A1 (ru) Триазолиламинопиримидиновые соединения
NZ593169A (en) Anticancer compounds
TN2010000489A1 (en) Disubstituted phthalazine hedgehog pathway antagonists
CY1114078T1 (el) Ανταγωνιστες διυποκατεστημενης φθαλαζινης του μονοπατιου hedgehog
TN2012000552A1 (en) An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative
UA101379C2 (en) Amidophenoxyindazoles useful in the treatment of cancer