CO6382123A2 - Antagonistas de la via hedgehog de ftalazina disustituida - Google Patents

Antagonistas de la via hedgehog de ftalazina disustituida

Info

Publication number
CO6382123A2
CO6382123A2 CO11058054A CO11058054A CO6382123A2 CO 6382123 A2 CO6382123 A2 CO 6382123A2 CO 11058054 A CO11058054 A CO 11058054A CO 11058054 A CO11058054 A CO 11058054A CO 6382123 A2 CO6382123 A2 CO 6382123A2
Authority
CO
Colombia
Prior art keywords
antagonists
ftalazina
disustituida
hedgehog
via hedgehog
Prior art date
Application number
CO11058054A
Other languages
English (en)
Spanish (es)
Inventor
Jolie Anne Bastian
Philip Arthur Hipskind
Takako Wilson
Daniel Jon Sall
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6382123(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO6382123A2 publication Critical patent/CO6382123A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CO11058054A 2008-11-03 2011-05-11 Antagonistas de la via hedgehog de ftalazina disustituida CO6382123A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11070308P 2008-11-03 2008-11-03

Publications (1)

Publication Number Publication Date
CO6382123A2 true CO6382123A2 (es) 2012-02-15

Family

ID=41566219

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11058054A CO6382123A2 (es) 2008-11-03 2011-05-11 Antagonistas de la via hedgehog de ftalazina disustituida

Country Status (29)

Country Link
US (1) US8404687B2 (OSRAM)
EP (1) EP2364185B1 (OSRAM)
JP (1) JP2012507535A (OSRAM)
KR (1) KR101335746B1 (OSRAM)
CN (1) CN102202737B (OSRAM)
AU (1) AU2009320251C1 (OSRAM)
BR (1) BRPI0921437A2 (OSRAM)
CA (1) CA2742539C (OSRAM)
CL (1) CL2011000979A1 (OSRAM)
CO (1) CO6382123A2 (OSRAM)
CR (1) CR20110202A (OSRAM)
CY (1) CY1114023T1 (OSRAM)
DK (1) DK2364185T3 (OSRAM)
EA (1) EA018931B1 (OSRAM)
EC (1) ECSP11011021A (OSRAM)
ES (1) ES2418479T3 (OSRAM)
HR (1) HRP20130527T1 (OSRAM)
IL (1) IL211841A0 (OSRAM)
MA (1) MA32726B1 (OSRAM)
MX (1) MX2011004683A (OSRAM)
NZ (1) NZ591945A (OSRAM)
PE (1) PE20110433A1 (OSRAM)
PL (1) PL2364185T3 (OSRAM)
PT (1) PT2364185E (OSRAM)
SI (1) SI2364185T1 (OSRAM)
TN (1) TN2011000166A1 (OSRAM)
UA (1) UA102115C2 (OSRAM)
WO (1) WO2010062507A1 (OSRAM)
ZA (1) ZA201102448B (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0809193A2 (pt) * 2007-03-15 2014-09-23 Novartis Ag Compostos orgânicos e seus usos
JP5442717B2 (ja) 2008-04-29 2014-03-12 イーライ リリー アンド カンパニー 二置換フタラジンヘッジホッグ経路アンタゴニスト
US20100041663A1 (en) * 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
HRP20120762T1 (hr) 2008-11-17 2012-10-31 Eli Lilly And Company Tetrasupstituirani piridazini kao inhibitori hedgehog puta
EP2358703B1 (en) 2008-11-17 2013-12-25 Eli Lilly and Company Tetrasubstituted pyridazines hedgehog pathway antagonists
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2015073691A1 (en) 2013-11-14 2015-05-21 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating cancer by activation of bmp signaling
CN105985321B (zh) * 2015-02-11 2018-10-26 复旦大学 吡唑酞嗪化合物及其制备方法和用途
CN105985320B (zh) * 2015-02-11 2018-10-26 复旦大学 苄基酞嗪化合物及其制备方法和用途
CN105985319B (zh) * 2015-02-11 2019-02-26 复旦大学 芳基酞嗪化合物及其制备方法和用途
WO2022081661A1 (en) 2020-10-13 2022-04-21 Endeavor Biomedicines, Inc. Methods of treating fibrosis
EP4590672A1 (en) * 2022-09-23 2025-07-30 Merck Sharp & Dohme LLC Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
US12447148B2 (en) 2024-03-05 2025-10-21 Endeavor Biomedicines, Inc. Methods of improving lung function

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
WO1998014431A1 (en) * 1996-10-01 1998-04-09 Kyowa Hakko Kogyo Co., Ltd. Nitrogenous heterocyclic compounds
CN1104430C (zh) 1996-01-15 2003-04-02 詹森药业有限公司 抑制血管生成的哒嗪胺
WO1999052534A1 (en) 1998-04-09 1999-10-21 Johns Hopkins University School Of Medicine Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways
US6432970B2 (en) * 1998-04-09 2002-08-13 Johns Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
ES2233383T3 (es) 1999-06-08 2005-06-16 Lorantis Limited Utilizacion terapeutica de un ihibidor de la via de señalizacion hedgehog.
US7655674B2 (en) 2002-04-22 2010-02-02 The Johns Hopkins University Modulators of hedgehog signaling pathways, compositions and uses related thereto
WO2004020599A2 (en) 2002-08-29 2004-03-11 Curis, Inc. Hedgehog antagonists, methods and uses related thereto
US8067608B2 (en) * 2003-09-29 2011-11-29 The Johns Hopkins University Hedgehog pathway antagonists
WO2005080378A1 (ja) 2004-02-24 2005-09-01 Mitsubishi Pharma Corporation 縮合ピリダジン誘導体
CA2564996A1 (en) 2004-05-08 2006-01-12 Taeyoung Yoon 3-aryl-5,6-disubstituted pyridazines
PT1789390E (pt) * 2004-09-02 2012-02-08 Genentech Inc Inibidores de piridilo da sinalização de hedgehog
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
BRPI0809193A2 (pt) 2007-03-15 2014-09-23 Novartis Ag Compostos orgânicos e seus usos
AU2008269128B2 (en) * 2007-06-25 2012-08-02 Amgen Inc. Phthalazine compounds, compositions and methods of use
AU2008300019A1 (en) 2007-09-07 2009-03-19 Amgen Inc. Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling
JP5442717B2 (ja) * 2008-04-29 2014-03-12 イーライ リリー アンド カンパニー 二置換フタラジンヘッジホッグ経路アンタゴニスト
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
EP2358703B1 (en) 2008-11-17 2013-12-25 Eli Lilly and Company Tetrasubstituted pyridazines hedgehog pathway antagonists
HRP20120762T1 (hr) 2008-11-17 2012-10-31 Eli Lilly And Company Tetrasupstituirani piridazini kao inhibitori hedgehog puta
AR077014A1 (es) * 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer

Also Published As

Publication number Publication date
US8404687B2 (en) 2013-03-26
MX2011004683A (es) 2011-06-20
EP2364185A1 (en) 2011-09-14
ECSP11011021A (es) 2011-06-30
IL211841A0 (en) 2011-06-30
US20110190304A1 (en) 2011-08-04
HK1159010A1 (en) 2012-07-27
NZ591945A (en) 2012-10-26
AU2009320251A1 (en) 2010-06-03
PE20110433A1 (es) 2011-07-09
HRP20130527T1 (en) 2013-07-31
CA2742539C (en) 2014-05-06
DK2364185T3 (da) 2013-06-03
PT2364185E (pt) 2013-07-24
ES2418479T3 (es) 2013-08-14
CA2742539A1 (en) 2010-06-03
CY1114023T1 (el) 2016-07-27
EA201170640A1 (ru) 2011-12-30
WO2010062507A1 (en) 2010-06-03
CN102202737B (zh) 2014-03-26
TN2011000166A1 (en) 2012-12-17
CL2011000979A1 (es) 2011-10-07
KR101335746B1 (ko) 2013-12-12
SI2364185T1 (sl) 2013-07-31
KR20110066212A (ko) 2011-06-16
PL2364185T3 (pl) 2013-10-31
ZA201102448B (en) 2012-09-26
BRPI0921437A2 (pt) 2018-10-30
JP2012507535A (ja) 2012-03-29
UA102115C2 (ru) 2013-06-10
AU2009320251C1 (en) 2013-08-15
CR20110202A (es) 2011-06-09
CN102202737A (zh) 2011-09-28
MA32726B1 (fr) 2011-10-02
EA018931B1 (ru) 2013-11-29
AU2009320251B2 (en) 2013-01-24
EP2364185B1 (en) 2013-05-22

Similar Documents

Publication Publication Date Title
CO6382123A2 (es) Antagonistas de la via hedgehog de ftalazina disustituida
ECSP11011541A (es) Antagonistas de la trayectoria hedgehog de ftalazina disustituida
CR11741A (es) Antagonistas de la trayectoria hedgehog de ftalazina disustituida
MY153915A (en) Organic compounds
EA201171367A1 (ru) Винилиндазолильные соединения
JO2788B1 (en) Amido phenoxyendazole compounds beneficial as C-MET inhibitors
TW201129567A (en) Materials for organic electroluminescent devices
TN2011000279A1 (en) Novel pyrazole -4-n-alkoxycarboxamides as microbiocides
CL2009000402A1 (es) Compuestos derivados de 2-amino-acetamida sustituida; composicion farmaceutica; utiles en el tratamiento de enfermedades pulmonares, enfermedad reumatica, enfermedad autoinmune, entre otras.
EA201170832A1 (ru) Пуриновые соединения
EA200971068A1 (ru) Триазолиламинопиримидиновые соединения
BRPI0814772A2 (pt) Indazóis substituídos por 5-piridinona
CL2009000119A1 (es) Compuestos derivados de amino-bencimidazoles sustituidos; composicion farmaceutica; y su uso en el tratamiento del alzheimer.
CL2008000629A1 (es) Compuestos macrociclicos derivados de 6-aril-4-mercapto-[1.3.5]triazina/[1.3]pirimidin-2-amina; composicion farmaceutica, utiles en el tratamiento del cancer.
MY149154A (en) Novel microbiocides
TW200700064A (en) Novel compounds
UA110332C2 (en) Use of 2,3-dihydroxypropyldodecanoate for treatment of seborrhea
CL2008001837A1 (es) Uso de compuestos derivados de cinolin-3-carboxamida en el tratamiento de la esquizofrenia.
EA200971067A1 (ru) Триазолиламинопиримидиновые соединения
TN2010000489A1 (en) Disubstituted phthalazine hedgehog pathway antagonists
TN2010000583A1 (en) Organic compounds
UA87793C2 (ru) 3-амино-1,1,1-трифторопропан-2-сульфонат натрия
CY1114078T1 (el) Ανταγωνιστες διυποκατεστημενης φθαλαζινης του μονοπατιου hedgehog
UA27723U (en) 7-? -hydroxy- ? -(2',4'-dichlorophenoxy)-propyl-8-n-(n'-?-hydroxyethyl)-piperazino-3- methylxanthine revealing hypocholesteremic action

Legal Events

Date Code Title Description
FG Application granted