PE20071225A1 - Compuestos derivados de piperidina como inhibidores de neurocinina-1 (nk-1) y del transportador de serotonina - Google Patents

Compuestos derivados de piperidina como inhibidores de neurocinina-1 (nk-1) y del transportador de serotonina

Info

Publication number
PE20071225A1
PE20071225A1 PE2007000467A PE2007000467A PE20071225A1 PE 20071225 A1 PE20071225 A1 PE 20071225A1 PE 2007000467 A PE2007000467 A PE 2007000467A PE 2007000467 A PE2007000467 A PE 2007000467A PE 20071225 A1 PE20071225 A1 PE 20071225A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
methyl
neurocinin
piperidine
Prior art date
Application number
PE2007000467A
Other languages
English (en)
Inventor
Andrew P Degnan
George Tora
Ying Han
Ramkumar Rajamani
Derek J Denhart
Jonathan L Ditta
Kevin W Gillman
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20071225A1 publication Critical patent/PE20071225A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Diabetes (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIPERIDINA DE FORMULA (I) DONDE R1 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C7) O BENCILO; R2 ES H O ALQUILO(C1-C6); R3 ES H O ALQUILO(C1-C6); R4 ES H, ALQUILO(C1-C6), HALOALQUILO(C1-C6), CN, ENTRE OTROS; R5 ES H, ALQUILO(C1-C6), HALOALQUILO(C1-C6), HIDROXI, ENTRE OTROS; Ar1 ES FENILO O PIRIDINILO SUSTITUIDO CON HALO, ALQUILO(C1-C6), HALOALQUILO(C1-C6), CN, FENILO O FURANILO; Ar2 ES FENILO, NAFTILO, FURANILO, ENTRE OTROS, SUSTITUIDOS CON HALO, ALQUILO(C1-C6), CN, NITRO, ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS: 2-METOXI-5-(3-(((4-FENILPIPERIDIN-4-IL)METOXI)METIL)-5-(TRIFLUOROMETIL)FENIL)PIRIMIDINA, 4-(5-(3-(((4-FENILPIPERIDIN-4-IL)METOXI)METIL)-5-(TRIFLUOROMETIL)FENIL)PIRIDIN-2-IL)MORFOLINA, 3-METIL-4-(3-(((4-FENILPIPERIDIN-4-IL)METOXI)METIL)-5-(TRIFLUOROMETIL)FENIL)PIRIDINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE NEUROCININA-1 (NK-1) Y DEL TRANSPORTADOR DE SEROTONINA SIENDO UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, DEMENCIA, ASMA, RINITIS
PE2007000467A 2006-04-17 2007-04-17 Compuestos derivados de piperidina como inhibidores de neurocinina-1 (nk-1) y del transportador de serotonina PE20071225A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79260406P 2006-04-17 2006-04-17
US11/734,809 US20070249607A1 (en) 2006-04-17 2007-04-13 Nk-1 and serotonin transporter inhibitors

Publications (1)

Publication Number Publication Date
PE20071225A1 true PE20071225A1 (es) 2008-01-14

Family

ID=38510473

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000467A PE20071225A1 (es) 2006-04-17 2007-04-17 Compuestos derivados de piperidina como inhibidores de neurocinina-1 (nk-1) y del transportador de serotonina

Country Status (5)

Country Link
US (2) US20070249607A1 (es)
AR (1) AR060496A1 (es)
PE (1) PE20071225A1 (es)
TW (1) TW200811135A (es)
WO (1) WO2007121389A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009000762A (es) * 2006-07-27 2009-01-28 Bristol Myers Squibb Co 4-arilalcoximetil-4-fenil piperidinas y su uso como antagonistas del receptor de neuroquinina para el tratamiento de trastornos del sistema nervioso central.
US8071778B2 (en) * 2006-07-27 2011-12-06 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in CNS disorders
MX2009013332A (es) 2007-06-08 2010-01-25 Mannkind Corp Inhibidores de ire-1 alfa.
US20090018163A1 (en) * 2007-07-11 2009-01-15 Bristol-Myers Squibb Company Substituted Heterocyclic Ethers and Their Use in CNS Disorders
US8026257B2 (en) * 2007-07-11 2011-09-27 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in CNS disorders
US7632861B2 (en) * 2007-11-13 2009-12-15 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in CNS disorders
WO2009096941A1 (en) * 2008-01-28 2009-08-06 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in cns disorders
PT2358674E (pt) 2008-11-14 2013-03-05 Theravance Inc Processo de preparação de compostos de 4-[2-(2-fluorofenoximetil)fenil]piperidina
JP7376358B2 (ja) 2017-03-12 2023-11-08 ワン，シャオドン オピオイド受容体調節因子としての多環式アミン

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337418C (en) 1988-03-28 1995-10-24 Engelbert Ciganek 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
JPH08502510A (ja) * 1992-10-28 1996-03-19 メルク シヤープ エンド ドーム リミテツド タキキニン拮抗剤としてのアリールメチルオキシメチルピペリジン
EP0739336B1 (en) 1994-01-13 1998-08-26 MERCK SHARP & DOHME LTD. Gem-disubstituted azacyclic tachykinin antagonists
PE20040682A1 (es) 2002-03-13 2004-10-07 Schering Corp Derivados de ciclobutano como antagonistas de nk1
CN1678317B (zh) 2002-07-03 2010-10-27 先灵公司 用作治疗呕吐、抑郁症、焦虑症和咳嗽的神经激肽-1(nk-1)拮抗剂的1-酰氨基-4-苯基-4-苄氧基甲基-哌啶衍生物和相关化合物
JP2006502157A (ja) 2002-09-09 2006-01-19 アストラゼネカ・アクチエボラーグ ナフチルエーテル化合物及びそれらの使用
US7138423B2 (en) 2004-07-20 2006-11-21 Bristol-Myers Squibb Company Arylpyrrolidine derivatives as NK-1 /SSRI antagonists
US7276631B2 (en) * 2004-07-20 2007-10-02 Bristol-Myers Squibb Company Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists
US7494986B2 (en) * 2004-07-20 2009-02-24 Bristol-Myers Squibb Company Cycloalkylamine derivatives as NK-1/SSRI antagonists
US7098203B2 (en) 2004-07-20 2006-08-29 Bristol-Myers Squibb Company Homopiperidine derivatives as NK-1 antagonists

Also Published As

Publication number Publication date
TW200811135A (en) 2008-03-01
AR060496A1 (es) 2008-06-18
WO2007121389A2 (en) 2007-10-25
US8383821B2 (en) 2013-02-26
WO2007121389A3 (en) 2008-02-21
US20100087434A1 (en) 2010-04-08
US20070249607A1 (en) 2007-10-25

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