PE20090068A1 - Compuestos de anillo fusionado como agonistas parciales de ppar gamma - Google Patents

Compuestos de anillo fusionado como agonistas parciales de ppar gamma

Info

Publication number
PE20090068A1
PE20090068A1 PE2008000266A PE2008000266A PE20090068A1 PE 20090068 A1 PE20090068 A1 PE 20090068A1 PE 2008000266 A PE2008000266 A PE 2008000266A PE 2008000266 A PE2008000266 A PE 2008000266A PE 20090068 A1 PE20090068 A1 PE 20090068A1
Authority
PE
Peru
Prior art keywords
dimethyl
ppar gamma
fused ring
pentilsulfonil
pyrrolo
Prior art date
Application number
PE2008000266A
Other languages
English (en)
Inventor
Taisuke Tawaraishi
Hiroshi Imoto
Nobuo Cho
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39523585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090068(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20090068A1 publication Critical patent/PE20090068A1/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
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  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
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Abstract

REFERIDA A UN COMPUESTO DE FORMULA (I'), DONDE LOS ANILLOS A Y B SON IGUALES O DIFERENTES Y CADA UNO ES UN MONOCICLO DE 5 A 7 MIEMBROS; EL ANILLO D' ES UN HETEROCICLO AROMATICO MONOCICLICO DE 5 MIEMBROS; Y' ES N O C; X ES UN ESPACIADOR QUE TIENE DE 1 A 4 ATOMOS EN LA CADENA PRINCIPAL; W ES -CONR1aS(O)mR2, -NR1bS(O)mNR1aCOnR2, -ONR1aCONR1cR2, ENTRE OTROS; R1a Y R1b SON H O ALQUILO C1-C6; R1c ES H, ALQUILO C1-C6 O ALCOXI C1-C6; R2 ES H, UN GRUPO HIDROCARBONADO O HETEROCICLO; m Y n SON 1 O 2. SON COMPUESTOS PREFERIDOS: (2E)-3-[1,3-DIMETIL-5-(1H-PIRROLO[2,3-b]PIRIDIN-1-IL)-1H-PIRAZOL-4-IL]-N-(PENTILSULFONIL)ACRILAMIDA, [(2-{1,3-DIMETIL-5-[5-(TRIFLUOROMETIL)-1H-PIRROLO[2,3-b]PIRIDIN-1-IL]-1H-PIRAZOL-4-IL}ETIL)SULFONIL]CARBAMATO DE BUTILO, (2E)-3-[5-CLORO-1H-INDOL-1-IL)-1,3-DIMETIL-1H-PIRAZOL-4-IL]-N-(PENTILSULFONIL)ACRILAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS TIENEN ACTIVIDAD AGONISTA PARCIAL SOBRE EL RECEPTOR GAMMA DE RESPUESTA AL CRECIMIENTO DE PEROXISOMAS (PPAR GAMMA) Y SON UTILES COMO HIPOGLICEMICOS, HIPOLIPIDEMICOS, SENSIBILIZANTES DE INSULINA
PE2008000266A 2007-02-09 2008-02-06 Compuestos de anillo fusionado como agonistas parciales de ppar gamma PE20090068A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007031221 2007-02-09

Publications (1)

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PE20090068A1 true PE20090068A1 (es) 2009-02-25

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Family Applications (1)

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PE2008000266A PE20090068A1 (es) 2007-02-09 2008-02-06 Compuestos de anillo fusionado como agonistas parciales de ppar gamma

Country Status (21)

Country Link
US (2) US20110009384A1 (es)
EP (1) EP2118066A1 (es)
JP (1) JP2010517935A (es)
KR (1) KR20090106660A (es)
CN (1) CN101646653A (es)
AR (1) AR065206A1 (es)
AU (1) AU2008215490A1 (es)
BR (1) BRPI0807014A2 (es)
CA (1) CA2677736A1 (es)
CL (1) CL2008000377A1 (es)
CR (1) CR10991A (es)
DO (1) DOP2009000202A (es)
EA (1) EA200970746A1 (es)
EC (1) ECSP099618A (es)
IL (1) IL200114A0 (es)
MA (1) MA31189B1 (es)
MX (1) MX2009008103A (es)
PE (1) PE20090068A1 (es)
TN (1) TN2009000312A1 (es)
TW (1) TW200838515A (es)
WO (1) WO2008099794A1 (es)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2242745A1 (de) * 2008-02-07 2010-10-27 Sanofi-Aventis Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
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