PE20081512A1 - Compuestos y composiciones como inhibidores de la actividad del receptor de canabinoide 1 - Google Patents
Compuestos y composiciones como inhibidores de la actividad del receptor de canabinoide 1Info
- Publication number
- PE20081512A1 PE20081512A1 PE2007001785A PE2007001785A PE20081512A1 PE 20081512 A1 PE20081512 A1 PE 20081512A1 PE 2007001785 A PE2007001785 A PE 2007001785A PE 2007001785 A PE2007001785 A PE 2007001785A PE 20081512 A1 PE20081512 A1 PE 20081512A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- halo
- compounds
- inhibitors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- -1 AMINO Chemical class 0.000 abstract 6
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
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- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
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- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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- C07D263/18—Oxygen atoms
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- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
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Abstract
REFERIDA A UN COMPUESTO DE FORMULA (I), EN DONDE Y1 ES N y CR11; Y2 ES N Y CR8; Z1 ES S, O, NH, ENTRE OTROS; Z2 ES O, -CH2CHR1a, -NR1a, ENTRE OTROS; R1a ES H, CIANO, ALQUILO C1-C6, ENTRE OTROS; R2a ES H, ALQUILO C1-C6; HALOALQUILO C1-C6, ENTRE OTROS; R2b ES H, ALQUILO C1-C6, ENTRE OTROS; R3, R5, R6 Y R7 SON H, HALO Y AMINO; R4 ES H, HALO, HIDROXI, ALQUILO C1-C6, ENTRE OTROS; R8, R9, R11 y R12a SON H, HALO, ALQUILO C1-C6, ENTRE OTROS; R10 ES HALO, CIANO, ALCOXI C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-[4-(4-CLORO-FENOXI)-FENIL]-5-FENIL-PIRROLIDI-2-NONA, 5-(4-AMINO-3-TRIFLUOROMETIL-FENIL)-1-[4-(4-CLORO-FENOXI)-FENIL]-PIRROLIDI-2-ONA, 1-[4-(4-CLORO-FENOXI)-FENIL]-5-(3-TRIFLUOROMETIL-FENIL)-PIRROLIDI-2-NONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DEL RECEPTOR DE CANABINOIDE 1 (CB1) Y SON UTILES EN EL TRATAMIENTO DE LA PSICOSIS, DEFICIENCIA DE LA MEMORIA, MIGRANA, NEUROPATIA, ACCIDENTES CEREBROVASCULARES, ENTRE OTROS
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EP (1) | EP2121598A2 (es) |
JP (2) | JP2010513299A (es) |
KR (2) | KR20120054106A (es) |
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CL (1) | CL2007003629A1 (es) |
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PE (1) | PE20081512A1 (es) |
TW (1) | TW200831080A (es) |
WO (1) | WO2008076754A2 (es) |
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EP2344157B1 (en) | 2008-09-04 | 2016-05-25 | Probiodrug AG | Novel inhibitors |
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FR2938538B1 (fr) * | 2008-11-17 | 2011-08-05 | Univ Nice Sophia Antipolis | Procede de preparation d'acides et d'esters boroniques en presence de magnesium metallique |
EP2375895A4 (en) * | 2008-12-11 | 2012-05-30 | Merck Sharp & Dohme | METHOD OF TREATING ALZHEIMER'S DISEASE AND RELATED STATES |
FR2941696B1 (fr) * | 2009-02-05 | 2011-04-15 | Sanofi Aventis | Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
RU2012129168A (ru) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | Производные оксазина |
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JPWO2012147763A1 (ja) | 2011-04-26 | 2014-07-28 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
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EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
JP6266659B2 (ja) | 2013-02-28 | 2018-01-24 | アムジエン・インコーポレーテツド | 癌の治療のための安息香酸誘導体mdm2阻害剤 |
US9758495B2 (en) | 2013-03-14 | 2017-09-12 | Amgen Inc. | Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer |
JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
CA2924353C (en) * | 2013-09-17 | 2018-12-04 | Vectus Biosystems Limited | Compositions for the treatment of hypertension and/or fibrosis |
TW201609710A (zh) * | 2013-12-10 | 2016-03-16 | 杜邦股份有限公司 | 除草用經取代嘧啶氧基苯化合物 |
PL3094631T3 (pl) | 2014-01-16 | 2019-07-31 | Fmc Corporation | Pochodne pirymidynyloksy-benzenu jako środki chwastobójcze |
MX371090B (es) * | 2014-06-09 | 2020-01-16 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica que contiene derivado de hidantoina. |
TW202400564A (zh) | 2015-06-05 | 2024-01-01 | 美商艾佛艾姆希公司 | 作為除草劑之嘧啶氧基苯衍生物 |
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EA202092094A1 (ru) | 2018-03-05 | 2020-12-10 | Бристол-Маерс Сквибб Компани | Фенилпирролидиноновые агонисты формилпептидного рецептора 2 |
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US10897925B2 (en) | 2018-07-27 | 2021-01-26 | Joseph Pandolfino | Articles and formulations for smoking products and vaporizers |
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CN113173916A (zh) * | 2021-03-31 | 2021-07-27 | 翟洪 | 一种托匹司他的制备方法 |
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DE4426757A1 (de) * | 1994-07-28 | 1996-02-01 | Bayer Ag | 2-Imidazolidinon-Derivate |
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EP1828163A2 (en) * | 2004-12-23 | 2007-09-05 | CHIESI FARMACEUTICI S.p.A. | Azole derivatives with antimuscarinic activity |
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AU2007333992B2 (en) | 2012-05-17 |
EP2121598A2 (en) | 2009-11-25 |
TW200831080A (en) | 2008-08-01 |
KR20090092322A (ko) | 2009-08-31 |
AR064353A1 (es) | 2009-04-01 |
WO2008076754A3 (en) | 2008-12-24 |
CA2672271C (en) | 2013-01-22 |
KR20120054106A (ko) | 2012-05-29 |
EA200900828A1 (ru) | 2009-12-30 |
US20130210769A1 (en) | 2013-08-15 |
WO2008076754A2 (en) | 2008-06-26 |
MX2009006339A (es) | 2009-08-21 |
JP2013014596A (ja) | 2013-01-24 |
AU2007333992A1 (en) | 2008-06-26 |
US20100234365A1 (en) | 2010-09-16 |
KR101245918B1 (ko) | 2013-03-20 |
BRPI0721163A2 (pt) | 2014-04-01 |
JP2010513299A (ja) | 2010-04-30 |
CA2672271A1 (en) | 2008-06-26 |
US8431607B2 (en) | 2013-04-30 |
EA017696B1 (ru) | 2013-02-28 |
CL2007003629A1 (es) | 2008-08-08 |
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