PE20081495A1 - Derivados 4,5-difenilpirrol-2-carboxamida como antagonistas de los receptores cb1 - Google Patents

Derivados 4,5-difenilpirrol-2-carboxamida como antagonistas de los receptores cb1

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Publication number
PE20081495A1
PE20081495A1 PE2007001599A PE2007001599A PE20081495A1 PE 20081495 A1 PE20081495 A1 PE 20081495A1 PE 2007001599 A PE2007001599 A PE 2007001599A PE 2007001599 A PE2007001599 A PE 2007001599A PE 20081495 A1 PE20081495 A1 PE 20081495A1
Authority
PE
Peru
Prior art keywords
alkyl
optionally substituted
diphenylpyrrol
antagonists
receptors
Prior art date
Application number
PE2007001599A
Other languages
English (en)
Inventor
Francis Barth
Christian Congy
Laurent Hortala
Murielle Rinaldi-Carmona
Original Assignee
Sanofi Aventis
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Publication date
Family has litigation
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Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20081495A1 publication Critical patent/PE20081495A1/es

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Abstract

SE REFIERE A DERIVADOS 4,5-DIFENILPIRROL-2-CARBOXAMIDA DE FORMULA (I), EN DONDE A ES ALQUILENO(C1-C6) OPCIONALMENTE SUSTITUIDOS POR ALQUILO(C1-C3), O UN GRUPO II); R1 ES H O ALQUILO(C1-C4); R2 ES ALQUILO(C1-C3), CARBOCICLICO NO AROMATICO (C3-C12), INDANILO, NR10R11, ENTRE OTROS; O R1 Y R2 JUNTOS AL N AL QUE ESTAN UNIDOS FORMAN MORFOLINILO, PIPERAZIN-1-ILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; R3, R4, R5, R6, R7 Y R8 SON INDEPENDIENTEMENTE H, HALOGENO, CN, ALQUILO(C1-C7), ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; R9 ES CN, CO2H, S02CH3, NR13R14, S02CF3, ENTRE OTROS. SON SELECCIONADOS: ACIDO 6-[5-(4-CARBAMOIL-[1,4']BIPIPERIDIN-1-IL-CARBONIL)-2-(4-CLOROFENIL)-3-(2,4-DICLOROFENIL)-1H-PIRROL-1-IL-HEXANOICO, 1-({5-(4-BROMOFENIL)-4-(2,4-DICLOROFENIL)-1-[2-(METILSULFONIL)ETIL]-1H-PIRROL-2-IL}CARBONIL)PIPERAZINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES CB1 DE LOS CANNABINOIDES A NIVEL CENTRAL Y/O PERIFERICO, SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR, TRASTORNOS DEL APETITO, ENTRE OTROS
PE2007001599A 2006-11-20 2007-11-16 Derivados 4,5-difenilpirrol-2-carboxamida como antagonistas de los receptores cb1 PE20081495A1 (es)

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FR0610202A FR2908766B1 (fr) 2006-11-20 2006-11-20 Derives de pyrrole,leur preparation et leur utilisation en therapeutique.

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FR2930940B1 (fr) * 2008-05-09 2011-02-11 Sanofi Aventis Derives de pyrrole, leur preparation et leur application en therapeutique
FR2930939B1 (fr) * 2008-05-09 2010-07-30 Sanofi Aventis Derives de pyrrole, leur preparation et leur application en therapeutique
CN102964304B (zh) * 2012-09-28 2015-06-17 苏州大学 含吡唑烷酮结构的手性氨基氰化物的制备方法
EP3486231B1 (en) * 2016-07-12 2020-05-20 Guangdong Raynovent Biotech Co., Ltd. Pyrrolidine derivative serving as ppar agonist
EP3696166B1 (en) 2017-12-21 2024-05-29 Guangdong Raynovent Biotech Co., Ltd. Amorphous pyrrolidine derivative as ppar agonist and preparation method thereof
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

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AU2002319627A1 (en) * 2001-07-20 2003-03-03 Merck And Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
FR2856683A1 (fr) * 2003-06-25 2004-12-31 Sanofi Synthelabo Derives de 4-cyanopyrazole-3-carboxamide, leur preparation et leur application en therapeutique
EP1756066B1 (en) * 2004-05-28 2008-08-20 Solvay Pharmaceuticals B.V. Tetrasubstituted imidazole derivatives as cannabinoid cb1 receptor modulators with a high cb1/cb2 receptor subtype selectivity
FR2874012B1 (fr) * 2004-08-09 2008-08-22 Sanofi Synthelabo Derives de pyrrole, leur preparation et leur utlisation en therapeutique
FR2881744B1 (fr) * 2005-02-09 2007-04-27 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
JP2008530179A (ja) * 2005-02-16 2008-08-07 ソルベイ・フアーマシユーチカルズ・ベー・ブイ カンナビノイドｃｂ２受容体モジュレーターとしての１ｈ−イミダゾール誘導体

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KR20090080992A (ko) 2009-07-27
JP2010510198A (ja) 2010-04-02
ZA200903865B (en) 2010-08-25
US8044072B2 (en) 2011-10-25
BRPI0718962A2 (pt) 2013-12-17
NO20092066L (no) 2009-08-11
US20090281116A1 (en) 2009-11-12
EP2094656A2 (fr) 2009-09-02
ATE520654T1 (de) 2011-09-15
FR2908766B1 (fr) 2009-01-09
AR064596A1 (es) 2009-04-15
DOP2009000105A (es) 2009-05-31
JP5210320B2 (ja) 2013-06-12
CA2669996A1 (fr) 2008-06-12
TN2009000166A1 (fr) 2010-10-18
ECSP099339A (es) 2009-06-30
CR10772A (es) 2009-07-23
WO2008068423A3 (fr) 2008-07-31
WO2008068423A2 (fr) 2008-06-12
EA200970497A1 (ru) 2009-10-30
MX2009005366A (es) 2009-06-08
SV2009003265A (es) 2010-02-05
UY30729A1 (es) 2008-07-03
IL198481A0 (en) 2010-02-17
MA30996B1 (fr) 2009-12-01
TW200829565A (en) 2008-07-16
AU2007330651A1 (en) 2008-06-12
EP2094656B1 (fr) 2011-08-17
FR2908766A1 (fr) 2008-05-23
CN101535250A (zh) 2009-09-16
CL2007003318A1 (es) 2008-07-04

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