PE20071237A1 - FORMA CRISTALINA DE 1'-(1-METILETIL)-4'-[(2-FLUORO-4-METOXIFENIL)METIL]-5'-METIL-1H-PIRAZOL-3'-O-ß-D-GLUCOPIRANOSIDO Y UN PROCEDIMIENTO DE PREPARACION - Google Patents

FORMA CRISTALINA DE 1'-(1-METILETIL)-4'-[(2-FLUORO-4-METOXIFENIL)METIL]-5'-METIL-1H-PIRAZOL-3'-O-ß-D-GLUCOPIRANOSIDO Y UN PROCEDIMIENTO DE PREPARACION

Info

Publication number
PE20071237A1
PE20071237A1 PE2007000017A PE2007000017A PE20071237A1 PE 20071237 A1 PE20071237 A1 PE 20071237A1 PE 2007000017 A PE2007000017 A PE 2007000017A PE 2007000017 A PE2007000017 A PE 2007000017A PE 20071237 A1 PE20071237 A1 PE 20071237A1
Authority
PE
Peru
Prior art keywords
methyl
crystalline form
glucopyranoside
methylethyl
pyrazole
Prior art date
Application number
PE2007000017A
Other languages
English (en)
Inventor
Gerd F Kraemer
Hans-Jurgen Martin
Gebhard Adelgoss
Klaus Dugi
Adil Duran
Peter Eickelmann
Steffen Maier
Sabine Pinnetti
Regine Ritter
Gebhard Schilcher
Ruediger Streicher
Leo Thomas
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20071237A1 publication Critical patent/PE20071237A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE REFIERE A UNA FORMA CRISTALINA DE 1'-(1-METILETIL)-4'-[(2-FLUORO-4-METOXIFENIL)METIL]-5'-METIL-1H-PIRAZOL-3'-O-ß-D-GLUCOPIRANOSIDO CARACTERIZADA POR PRESENTAR UN PATRON DE DIFRACCION DE RAYOS X EN POLVO QUE COMPRENDE PICOS A 5,35; 9,31; 10,76; 16,20 Y 19,81 GRADOS 2? (± 0,1 GRADOS), DONDE DICHA FORMA CRISTALINA CONTIENE AGUA EN UN INTERVALO DE 0 A 10% EN PESO Y AL MENOS 50% EN PESO ESTA PRESENTE EN FORMA CRITALINA. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN METODO PARA PREPARAR DICHA FORMA CRISTALINA, DICHO COMPUESTO ES UN INHIBIDOR DEL COTRANSPORTADOR SGLT2 DE GLUCOSA DEPENDIENTE DE SODIO, POR LO QUE ES UTIL EN EL TRATAMIENTO DE UN TRASTORNO METABOLICO TAL COMO DIABETES
PE2007000017A 2006-01-11 2007-01-09 FORMA CRISTALINA DE 1'-(1-METILETIL)-4'-[(2-FLUORO-4-METOXIFENIL)METIL]-5'-METIL-1H-PIRAZOL-3'-O-ß-D-GLUCOPIRANOSIDO Y UN PROCEDIMIENTO DE PREPARACION PE20071237A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06000483 2006-01-11

Publications (1)

Publication Number Publication Date
PE20071237A1 true PE20071237A1 (es) 2008-01-15

Family

ID=35953998

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000017A PE20071237A1 (es) 2006-01-11 2007-01-09 FORMA CRISTALINA DE 1'-(1-METILETIL)-4'-[(2-FLUORO-4-METOXIFENIL)METIL]-5'-METIL-1H-PIRAZOL-3'-O-ß-D-GLUCOPIRANOSIDO Y UN PROCEDIMIENTO DE PREPARACION

Country Status (19)

Country Link
US (2) US7524822B2 (es)
EP (1) EP1976859A1 (es)
JP (1) JP4936234B2 (es)
KR (1) KR20090012205A (es)
CN (1) CN101370816A (es)
AR (1) AR058962A1 (es)
AU (1) AU2007204368A1 (es)
BR (1) BRPI0706375A2 (es)
CA (1) CA2635203A1 (es)
EA (1) EA200801663A1 (es)
EC (1) ECSP088501A (es)
IL (1) IL192655A0 (es)
NO (1) NO20082395L (es)
NZ (1) NZ570311A (es)
PE (1) PE20071237A1 (es)
TW (1) TW200745149A (es)
UY (1) UY30082A1 (es)
WO (1) WO2007080170A1 (es)
ZA (1) ZA200804151B (es)

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JP5467040B2 (ja) * 2008-04-16 2014-04-09 キッセイ薬品工業株式会社 ピラゾール誘導体の１／２フマル酸塩
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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
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WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2014161836A1 (en) 2013-04-04 2014-10-09 Boehringer Ingelheim Vetmedica Gmbh Treatment of metabolic disorders in equine animals
PL3082829T3 (pl) 2013-12-17 2021-09-06 Boehringer Ingelheim Vetmedica Gmbh Inhibitory sglt2 do leczenia zaburzeń metabolicznych u zwierząt kotowatych
US10603300B2 (en) * 2014-01-23 2020-03-31 Boehringer Ingelheim Vetmedica Gmbh Treatment of metabolic disorders in canine animals
CN106061950B (zh) * 2014-02-28 2019-05-03 住友化学株式会社 吡唑化合物的制造方法
HUE068880T2 (hu) 2014-04-01 2025-02-28 Boehringer Ingelheim Vetmedica Gmbh Hipofízis pars intermedia diszfunkció kezelése lófélékben
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Also Published As

Publication number Publication date
US20090181905A1 (en) 2009-07-16
ECSP088501A (es) 2008-07-30
TW200745149A (en) 2007-12-16
CA2635203A1 (en) 2007-07-19
NZ570311A (en) 2010-05-28
IL192655A0 (en) 2009-02-11
US7838500B2 (en) 2010-11-23
AR058962A1 (es) 2008-03-05
CN101370816A (zh) 2009-02-18
EA200801663A1 (ru) 2009-02-27
KR20090012205A (ko) 2009-02-02
AU2007204368A1 (en) 2007-07-19
JP4936234B2 (ja) 2012-05-23
ZA200804151B (en) 2009-10-28
JP2009522340A (ja) 2009-06-11
EP1976859A1 (en) 2008-10-08
BRPI0706375A2 (pt) 2011-03-22
WO2007080170A1 (en) 2007-07-19
US20070244176A1 (en) 2007-10-18
UY30082A1 (es) 2007-08-31
US7524822B2 (en) 2009-04-28
NO20082395L (no) 2008-07-31

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