PE20071000A1 - Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido - Google Patents

Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido

Info

Publication number
PE20071000A1
PE20071000A1 PE2006001569A PE2006001569A PE20071000A1 PE 20071000 A1 PE20071000 A1 PE 20071000A1 PE 2006001569 A PE2006001569 A PE 2006001569A PE 2006001569 A PE2006001569 A PE 2006001569A PE 20071000 A1 PE20071000 A1 PE 20071000A1
Authority
PE
Peru
Prior art keywords
rapamycin
differential scanning
scanning calorimetry
crystallinity
crystal
Prior art date
Application number
PE2006001569A
Other languages
English (en)
Inventor
Subodh S Deshmukh
Mahmoud Mirmehrabi
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20071000A1 publication Critical patent/PE20071000A1/es

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
    • G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample
    • G01N25/4866—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample by using a differential method

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Combustion & Propulsion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PURIFICACION DE RAPAMICINA DE PREFERENCIA CCI-779 (TEMSIROLIMUS) CRISTALINA QUE COMPRENDE: A) CALENTAR LA RAPAMICINA SIN PURIFICAR EN ACETATO DE ETILO A 55 C APROX. Y FILTRAR; B) AGREGAR HEPTANOS EN EL CURSO DE UN PERIODO DE 60 MINUTOS APROX. A VELOCIDAD CONSTANTE; C) REDUCIR LA VELOCIDAD DE AGITACION Y ENFRIAR EL PRODUCTO HASTA APROXIMADAMENTE 7 C A 8 C A DIFERENTES VELOCIDADES HASTA LLEGAR A 9 C/HORA; D) FILTRAR EL PRODUCTO PARA OBTENER DICHA RAPAMICINA CRISTALINA. REFERIDA TAMBIEN A UN METODO PARA MEDIR LA CALIDAD DE PARTICULA DE UN COMPUESTO DE RAPAMICINA UTILIZANDO CALORIMETRIA DIFERENCIAL DE BARRIDO DONDE LA CALIDAD DE PARTICULAS ES PROPORCIONAL A LA TEMPERATURA DE FUSION DE CALOR DE DICHA MUESTRA
PE2006001569A 2005-12-07 2006-12-06 Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido PE20071000A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74800505P 2005-12-07 2005-12-07

Publications (1)

Publication Number Publication Date
PE20071000A1 true PE20071000A1 (es) 2007-10-10

Family

ID=38117222

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001569A PE20071000A1 (es) 2005-12-07 2006-12-06 Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido

Country Status (17)

Country Link
US (1) US20070128731A1 (es)
EP (1) EP1957964A2 (es)
JP (1) JP2009518648A (es)
KR (1) KR20080077147A (es)
CN (1) CN101351702A (es)
AR (1) AR058283A1 (es)
AU (1) AU2006322030A1 (es)
BR (1) BRPI0619592A2 (es)
CA (1) CA2630786A1 (es)
CR (1) CR9985A (es)
EC (1) ECSP088519A (es)
IL (1) IL191545A0 (es)
NO (1) NO20082382L (es)
PE (1) PE20071000A1 (es)
RU (1) RU2008120712A (es)
TW (1) TW200736603A (es)
WO (1) WO2007067566A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5643770B2 (ja) * 2009-01-21 2014-12-17 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ シロリムスの安定性の決定方法およびその安定形態の調製方法
FR2943539B1 (fr) 2009-03-31 2011-07-22 Ethypharm Sa Composition pharmaceutique comprenant un macrolide immunosuppresseur de la famille des limus.
WO2013022418A1 (en) * 2011-08-05 2013-02-14 Crucible Intellectual Property Llc Nondestructive method to determine crystallinity in amorphous alloy
WO2013162501A1 (en) * 2012-04-23 2013-10-31 Apple Inc. Non-destructive determination of volumetric crystallinity of bulk amorphous alloy
SG10201707632PA (en) 2013-03-15 2017-11-29 Biosensors Int Group Ltd Purification of rapamycin derivatives
US9439892B2 (en) 2013-05-16 2016-09-13 Surmodics, Inc. Macrolide particulates, methods for preparation, and medical devices associated therewith
EP3007679B1 (en) * 2013-06-12 2020-11-11 SurModics, Inc. Solvent methods for preparing crystalline macrolide particulates, compositions, and articles containing particulates
DE102013110294B4 (de) * 2013-09-18 2016-07-07 Innora Gmbh Limus-Depot-Formulierung auf Ballonkathetern
WO2015181826A1 (en) 2014-05-27 2015-12-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Crystalline coating and release of bioactive agents
CN105116013A (zh) * 2015-04-23 2015-12-02 山东农业大学 一种确定金属离子对蛋白酶水解大豆分离蛋白影响的方法
JP6531488B2 (ja) * 2015-05-22 2019-06-19 日産自動車株式会社 リチウムイオン二次電池の熱履歴検知方法
EP3435988B1 (en) 2016-03-31 2021-10-06 Surmodics, Inc. Drug-containing particulate composition with cationic agent, associated medical devices, and methods for treatment
US11123459B2 (en) 2016-12-16 2021-09-21 Surmodics, Inc. Hydrophobic active agent particle coatings and methods for treatment
US11629222B2 (en) * 2019-07-01 2023-04-18 Ethicon, Inc. Calorimetric crystallization method for evaluation of monomer purity
NL2031004B1 (en) * 2022-02-18 2023-09-05 Univ Delft Tech Novel method for analyzing DSC data
WO2023158308A1 (en) 2022-02-18 2023-08-24 Technische Universiteit Delft Novel method for analyzing dsc data

Family Cites Families (25)

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ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US5358909A (en) * 1991-02-27 1994-10-25 Nippon Steel Corporation Method of manufacturing field-emitter
US5358908A (en) * 1992-02-14 1994-10-25 Micron Technology, Inc. Method of creating sharp points and other features on the surface of a semiconductor substrate
GB9313650D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US5385908A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5385909A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
DE19825472B4 (de) * 1997-06-06 2005-05-25 Netzsch-Gerätebau GmbH Vorrichtung zur Differential-Scanning-Kalorimetrie
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US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
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ATE411321T1 (de) * 2000-09-19 2008-10-15 Wyeth Corp Wasserlösliche rapamycin-ester
DE60210794T2 (de) * 2001-10-17 2007-05-10 E.I. Dupont De Nemours And Co., Wilmington Rotor-stator apparat und verfahren zur bildung von partikeln
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
KR20060052874A (ko) * 2003-07-24 2006-05-19 테바 기오기스제르갸르 레스즈베니타르사사그 마크로라이드의 정제 방법
ATE365169T1 (de) * 2003-08-07 2007-07-15 Wyeth Corp Regioselektive synthese von cci-779
SG145716A1 (en) * 2003-09-03 2008-09-29 Wyeth Corp Amorphous rapamycin 42-ester with 3-hydroxy-2- (hydroxymethyl)-2- methylpropionic acid and pharmaceutical compositions containing the same
DE602005010228D1 (de) * 2004-04-14 2008-11-20 Wyeth Corp Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper
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EP1776370A1 (en) * 2004-08-10 2007-04-25 Wyeth a Corporation of the State of Delaware Cci-779 derivatives and methods of making same
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JP2008524232A (ja) * 2004-12-20 2008-07-10 ワイス ラパマイシン誘導体及び神経障害の治療におけるその使用
JP2008530090A (ja) * 2005-02-09 2008-08-07 ワイス Ｃｃｉ−７７９多形及びその使用
EP1853611A1 (en) * 2005-03-02 2007-11-14 Wyeth Recovery of cci-779 from mother liquors
CN101137659A (zh) * 2005-03-07 2008-03-05 惠氏公司 42-o-（2-羟基）乙基-雷帕霉素的氧杂环庚烷异构体

Also Published As

Publication number Publication date
KR20080077147A (ko) 2008-08-21
CA2630786A1 (en) 2007-06-14
BRPI0619592A2 (pt) 2016-09-06
IL191545A0 (en) 2008-12-29
CR9985A (es) 2008-08-21
WO2007067566A3 (en) 2008-01-24
RU2008120712A (ru) 2010-01-20
TW200736603A (en) 2007-10-01
EP1957964A2 (en) 2008-08-20
AU2006322030A1 (en) 2007-06-14
NO20082382L (no) 2008-09-04
ECSP088519A (es) 2008-07-30
WO2007067566A2 (en) 2007-06-14
CN101351702A (zh) 2009-01-21
JP2009518648A (ja) 2009-05-07
AR058283A1 (es) 2008-01-30
US20070128731A1 (en) 2007-06-07

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