ECSP088519A - Metodos para preparar rapamicina cristalina y para medir la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido - Google Patents

Metodos para preparar rapamicina cristalina y para medir la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido

Info

Publication number
ECSP088519A
ECSP088519A EC2008008519A ECSP088519A ECSP088519A EC SP088519 A ECSP088519 A EC SP088519A EC 2008008519 A EC2008008519 A EC 2008008519A EC SP088519 A ECSP088519 A EC SP088519A EC SP088519 A ECSP088519 A EC SP088519A
Authority
EC
Ecuador
Prior art keywords
rapamycin
methods
crystalinity
calorimetry
measure
Prior art date
Application number
EC2008008519A
Other languages
English (en)
Inventor
Subodh S Deshmukh
Mahmoud Mirmehrabi
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP088519A publication Critical patent/ECSP088519A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
    • G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample
    • G01N25/4866—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample by using a differential method

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Combustion & Propulsion (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)

Abstract

Se describen los métodos para purificar la rapamicina; también se proveen los métodos para medir la calidad de partícula, el tamaño de partícula medio y la cristalinidad de las muestras que contienen rapamicina o un derivado de la misma.
EC2008008519A 2005-12-07 2008-06-09 Metodos para preparar rapamicina cristalina y para medir la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido ECSP088519A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74800505P 2005-12-07 2005-12-07

Publications (1)

Publication Number Publication Date
ECSP088519A true ECSP088519A (es) 2008-07-30

Family

ID=38117222

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008519A ECSP088519A (es) 2005-12-07 2008-06-09 Metodos para preparar rapamicina cristalina y para medir la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido

Country Status (17)

Country Link
US (1) US20070128731A1 (es)
EP (1) EP1957964A2 (es)
JP (1) JP2009518648A (es)
KR (1) KR20080077147A (es)
CN (1) CN101351702A (es)
AR (1) AR058283A1 (es)
AU (1) AU2006322030A1 (es)
BR (1) BRPI0619592A2 (es)
CA (1) CA2630786A1 (es)
CR (1) CR9985A (es)
EC (1) ECSP088519A (es)
IL (1) IL191545A0 (es)
NO (1) NO20082382L (es)
PE (1) PE20071000A1 (es)
RU (1) RU2008120712A (es)
TW (1) TW200736603A (es)
WO (1) WO2007067566A2 (es)

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US20110275798A1 (en) * 2009-01-21 2011-11-10 Rakesh Bhaiyyaram Mendhe Method for Determination of Sirolimus Stability and Process for Preparing Its Stable Form
FR2943539B1 (fr) 2009-03-31 2011-07-22 Ethypharm Sa Composition pharmaceutique comprenant un macrolide immunosuppresseur de la famille des limus.
US20140297202A1 (en) * 2011-08-05 2014-10-02 Apple Inc. Nondestructive method to determine crystallinity in amorphous alloy
WO2013162501A1 (en) * 2012-04-23 2013-10-31 Apple Inc. Non-destructive determination of volumetric crystallinity of bulk amorphous alloy
WO2014145780A1 (en) 2013-03-15 2014-09-18 Biosensors International Group, Ltd. Purification of rapamycin derivatives
US9439892B2 (en) 2013-05-16 2016-09-13 Surmodics, Inc. Macrolide particulates, methods for preparation, and medical devices associated therewith
CA2915704C (en) * 2013-06-12 2022-06-21 Surmodics, Inc. Solvent methods for preparing crystalline macrolide particulates, compositions, and articles containing particulates
DE102013110294B4 (de) * 2013-09-18 2016-07-07 Innora Gmbh Limus-Depot-Formulierung auf Ballonkathetern
WO2015181826A1 (en) 2014-05-27 2015-12-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Crystalline coating and release of bioactive agents
CN105116013A (zh) * 2015-04-23 2015-12-02 山东农业大学 一种确定金属离子对蛋白酶水解大豆分离蛋白影响的方法
JP6531488B2 (ja) * 2015-05-22 2019-06-19 日産自動車株式会社 リチウムイオン二次電池の熱履歴検知方法
EP3435988B1 (en) 2016-03-31 2021-10-06 Surmodics, Inc. Drug-containing particulate composition with cationic agent, associated medical devices, and methods for treatment
WO2018112196A1 (en) 2016-12-16 2018-06-21 Surmodics, Inc. Hydrophobic active agent particle coatings and methods for treatment
US11629222B2 (en) * 2019-07-01 2023-04-18 Ethicon, Inc. Calorimetric crystallization method for evaluation of monomer purity
NL2031004B1 (en) * 2022-02-18 2023-09-05 Univ Delft Tech Novel method for analyzing DSC data
WO2023158308A1 (en) 2022-02-18 2023-08-24 Technische Universiteit Delft Novel method for analyzing dsc data

Family Cites Families (25)

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ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US5358909A (en) * 1991-02-27 1994-10-25 Nippon Steel Corporation Method of manufacturing field-emitter
US5358908A (en) * 1992-02-14 1994-10-25 Micron Technology, Inc. Method of creating sharp points and other features on the surface of a semiconductor substrate
GB9313650D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US5385909A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5385908A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
EP0884585A3 (de) * 1997-06-06 1999-12-29 Netzsch Gerätebau GmbH Vorrichtung zur Differential-Scanning-Kalorimetrie
GB9826882D0 (en) * 1998-12-07 1999-01-27 Novartis Ag Organic compounds
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
JP2004509898A (ja) * 2000-09-19 2004-04-02 ワイス 水溶性ラパマイシンエステル
WO2003033097A2 (en) * 2001-10-17 2003-04-24 E.I. Du Pont De Nemours And Company Rotor-stator apparatus and process for the formation of particles
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
US7220357B2 (en) * 2003-07-24 2007-05-22 Teva Gyógyszergyár Zártkörúen Múkó´dó´Résvénytársaság Method of purifying macrolides
RU2339639C2 (ru) * 2003-08-07 2008-11-27 Уайт Региоселективный синтез cci-779
JP2007504226A (ja) * 2003-09-03 2007-03-01 ワイス 非晶質状のラパマイシンの３−ヒドロキシ−２−（ヒドロキシメチル）−２−メチルプロピオン酸との４２−エステル、およびそれを含むその医薬組成物
AU2005238431A1 (en) * 2004-04-14 2005-11-10 Wyeth Regiospecific synthesis of rapamycin 42-ester derivatives
US7445916B2 (en) * 2004-04-14 2008-11-04 Wyeth Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
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DK1828202T3 (da) * 2004-12-20 2012-05-07 Wyeth Llc Rapamycinanaloge samt deres anvendelse ved behandling af neurologiske, proliferative og inflammatoriske lidelser
JP2008524232A (ja) * 2004-12-20 2008-07-10 ワイス ラパマイシン誘導体及び神経障害の治療におけるその使用
US7442707B2 (en) * 2005-02-09 2008-10-28 Wyeth CCI-779 polymorph and use thereof
BRPI0607390A2 (pt) * 2005-03-02 2017-08-22 Wyeth Corp Processo para recuperar cci-779 de licores mâe
JP2008533007A (ja) * 2005-03-07 2008-08-21 ワイス ４２−ｏ−（２−ヒドロキシ）エチル−ラパマイシンのオキセパン異性体

Also Published As

Publication number Publication date
EP1957964A2 (en) 2008-08-20
AU2006322030A1 (en) 2007-06-14
CA2630786A1 (en) 2007-06-14
JP2009518648A (ja) 2009-05-07
IL191545A0 (en) 2008-12-29
RU2008120712A (ru) 2010-01-20
AR058283A1 (es) 2008-01-30
CN101351702A (zh) 2009-01-21
BRPI0619592A2 (pt) 2016-09-06
KR20080077147A (ko) 2008-08-21
WO2007067566A3 (en) 2008-01-24
PE20071000A1 (es) 2007-10-10
WO2007067566A2 (en) 2007-06-14
TW200736603A (en) 2007-10-01
NO20082382L (no) 2008-09-04
CR9985A (es) 2008-08-21
US20070128731A1 (en) 2007-06-07

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