PE20060628A1 - Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos como inhibidores de cpla2 - Google Patents
Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos como inhibidores de cpla2Info
- Publication number
- PE20060628A1 PE20060628A1 PE2005000959A PE2005000959A PE20060628A1 PE 20060628 A1 PE20060628 A1 PE 20060628A1 PE 2005000959 A PE2005000959 A PE 2005000959A PE 2005000959 A PE2005000959 A PE 2005000959A PE 20060628 A1 PE20060628 A1 PE 20060628A1
- Authority
- PE
- Peru
- Prior art keywords
- terreo
- mol
- cpla2
- inhibitors
- formula
- Prior art date
Links
- 102100037611 Lysophospholipase Human genes 0.000 title abstract 2
- 101150093295 Pla2g4a gene Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002184 metal Substances 0.000 abstract 4
- 229910052751 metal Inorganic materials 0.000 abstract 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60312404P | 2004-08-19 | 2004-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060628A1 true PE20060628A1 (es) | 2006-08-14 |
Family
ID=35219553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000959A PE20060628A1 (es) | 2004-08-19 | 2005-08-18 | Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos como inhibidores de cpla2 |
Country Status (24)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US7713964B2 (en) * | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| US7342119B2 (en) * | 2003-09-30 | 2008-03-11 | Wyeth Holdings Corporation | Process for the synthesis of a CPLA2 inhibitor |
| HN2004000536A (es) | 2003-12-16 | 2009-02-18 | Wyeth Corp | Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles |
| TW200718687A (en) * | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
| WO2008055148A2 (en) * | 2006-10-31 | 2008-05-08 | Wyeth | Semi-solid formulations of phospholipase enzyme inhibitors |
| CL2007003143A1 (es) * | 2006-10-31 | 2008-01-25 | Wyeth Corp | Composicion farmaceutica que comprende un compuesto derivado de indol y un sistema portador que comprende 10-50% de un primer solubilizante, 5-50% de un segundo solubilizante, 10-30% de un primer diluyente y 1-15% de un segundo diluyente; proceso de prepracion; y forma de dosificacion. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02115157A (ja) * | 1988-10-24 | 1990-04-27 | Hokko Chem Ind Co Ltd | スルホニルグリシン誘導体および除草剤 |
| UA81596C2 (en) * | 1999-12-09 | 2008-01-25 | Авентис Кропсаенс Гмбх | Nitro-sulfobenzamides |
| US6984735B2 (en) * | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US7713964B2 (en) * | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| US6797708B2 (en) * | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| US7101875B2 (en) * | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
| HUP0402577A3 (en) * | 2001-12-03 | 2011-05-30 | Wyeth Corp | Indole derivatives as inhibitors of cytosolic phospholipase a2, process for producing them and pharmaceutical compositions containing them |
| US6635771B2 (en) * | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
| TW200510305A (en) * | 2003-07-25 | 2005-03-16 | Wyeth Corp | Process for the preparation of CPLA2 inhibitors |
| WO2005012235A1 (en) | 2003-07-29 | 2005-02-10 | Ciba Specialty Chemicals Holding Inc. | 3-aryl-2-cyano-3-hydroxy-acrylic acid derivatives |
| US7582771B2 (en) * | 2003-09-03 | 2009-09-01 | Wyeth | Process for the synthesis of cPLA2 inhibitors |
| US7342119B2 (en) * | 2003-09-30 | 2008-03-11 | Wyeth Holdings Corporation | Process for the synthesis of a CPLA2 inhibitor |
| HN2004000536A (es) * | 2003-12-16 | 2009-02-18 | Wyeth Corp | Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles |
-
2005
- 2005-08-16 AR ARP050103452A patent/AR053410A1/es unknown
- 2005-08-18 BR BRPI0514431-0A patent/BRPI0514431A/pt not_active IP Right Cessation
- 2005-08-18 TW TW094128146A patent/TW200609214A/zh unknown
- 2005-08-18 RU RU2007105231/04A patent/RU2401829C2/ru not_active IP Right Cessation
- 2005-08-18 SV SV2005002200A patent/SV2006002200A/es unknown
- 2005-08-18 AT AT05788529T patent/ATE517084T1/de not_active IP Right Cessation
- 2005-08-18 SG SG200905383-6A patent/SG155214A1/en unknown
- 2005-08-18 EP EP05788529A patent/EP1778629B1/en not_active Expired - Lifetime
- 2005-08-18 AU AU2005277392A patent/AU2005277392A1/en not_active Abandoned
- 2005-08-18 WO PCT/US2005/029338 patent/WO2006023611A1/en not_active Ceased
- 2005-08-18 US US11/207,072 patent/US7582772B2/en not_active Expired - Fee Related
- 2005-08-18 GT GT200500224A patent/GT200500224A/es unknown
- 2005-08-18 MX MX2007002042A patent/MX2007002042A/es not_active Application Discontinuation
- 2005-08-18 KR KR1020077005610A patent/KR20070043036A/ko not_active Ceased
- 2005-08-18 UA UAA200701724A patent/UA85428C2/ru unknown
- 2005-08-18 PE PE2005000959A patent/PE20060628A1/es not_active Application Discontinuation
- 2005-08-18 CA CA002576008A patent/CA2576008A1/en not_active Abandoned
- 2005-08-18 JP JP2007527996A patent/JP2008510707A/ja not_active Ceased
- 2005-08-18 CN CN201010200760A patent/CN101830837A/zh active Pending
- 2005-08-18 CN CN2005800280209A patent/CN101006048B/zh not_active Expired - Fee Related
- 2005-08-24 HN HN2005000474A patent/HN2005000474A/es unknown
-
2007
- 2007-02-13 EC EC2007007244A patent/ECSP077244A/es unknown
- 2007-02-15 IL IL181364A patent/IL181364A0/en unknown
- 2007-02-19 CR CR8936A patent/CR8936A/es not_active Application Discontinuation
- 2007-03-07 NO NO20071253A patent/NO20071253L/no not_active Application Discontinuation
-
2009
- 2009-08-18 US US12/542,914 patent/US7842837B2/en not_active Expired - Fee Related
-
2010
- 2010-11-11 US US12/943,958 patent/US8034960B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101006048B (zh) | 2011-07-06 |
| ECSP077244A (es) | 2007-03-29 |
| KR20070043036A (ko) | 2007-04-24 |
| JP2008510707A (ja) | 2008-04-10 |
| HN2005000474A (es) | 2009-04-07 |
| AR053410A1 (es) | 2007-05-09 |
| US20060041005A1 (en) | 2006-02-23 |
| TW200609214A (en) | 2006-03-16 |
| NO20071253L (no) | 2007-05-15 |
| AU2005277392A1 (en) | 2006-03-02 |
| CN101006048A (zh) | 2007-07-25 |
| US8034960B2 (en) | 2011-10-11 |
| GT200500224A (es) | 2006-03-21 |
| EP1778629B1 (en) | 2011-07-20 |
| RU2401829C2 (ru) | 2010-10-20 |
| US7582772B2 (en) | 2009-09-01 |
| SG155214A1 (en) | 2009-09-30 |
| US20090306428A1 (en) | 2009-12-10 |
| ATE517084T1 (de) | 2011-08-15 |
| US7842837B2 (en) | 2010-11-30 |
| EP1778629A1 (en) | 2007-05-02 |
| US20110054189A1 (en) | 2011-03-03 |
| UA85428C2 (ru) | 2009-01-26 |
| CN101830837A (zh) | 2010-09-15 |
| SV2006002200A (es) | 2006-05-09 |
| BRPI0514431A (pt) | 2008-06-10 |
| CR8936A (es) | 2007-04-26 |
| RU2007105231A (ru) | 2008-09-27 |
| IL181364A0 (en) | 2007-07-04 |
| CA2576008A1 (en) | 2006-03-02 |
| MX2007002042A (es) | 2007-03-29 |
| WO2006023611A1 (en) | 2006-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |