PE20050201A1 - Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetilo - Google Patents
Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetiloInfo
- Publication number
- PE20050201A1 PE20050201A1 PE2004000472A PE2004000472A PE20050201A1 PE 20050201 A1 PE20050201 A1 PE 20050201A1 PE 2004000472 A PE2004000472 A PE 2004000472A PE 2004000472 A PE2004000472 A PE 2004000472A PE 20050201 A1 PE20050201 A1 PE 20050201A1
- Authority
- PE
- Peru
- Prior art keywords
- pyrazole
- methylphenyl
- alkyl
- cyclylmethyl
- alkylmethyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 2-METHYLPHENYL Chemical class 0.000 abstract 2
- MJQOLPWOOIMZDA-UHFFFAOYSA-N 5-amino-1-(4-methylphenyl)pyrazole-4-carbonitrile Chemical compound C1=CC(C)=CC=C1N1C(N)=C(C#N)C=N1 MJQOLPWOOIMZDA-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical class O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000008447 perception Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10320784 | 2003-05-09 | ||
| DE10336183 | 2003-08-07 | ||
| DE102004004142A DE102004004142A1 (de) | 2003-05-09 | 2004-01-28 | 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050201A1 true PE20050201A1 (es) | 2005-05-27 |
Family
ID=33420016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000472A PE20050201A1 (es) | 2003-05-09 | 2004-05-07 | Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetilo |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2298773B1 (https=) |
| JP (1) | JP5277303B2 (https=) |
| CL (1) | CL2004000978A1 (https=) |
| DE (1) | DE102004004142A1 (https=) |
| MY (1) | MY148252A (https=) |
| NZ (1) | NZ543812A (https=) |
| PE (1) | PE20050201A1 (https=) |
| RU (1) | RU2383546C2 (https=) |
| TW (1) | TWI350836B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201439091A (zh) * | 2013-04-05 | 2014-10-16 | Eisai R&D Man Co Ltd | 吡啶基吡唑并喹啉化合物 |
| WO2018221550A1 (ja) | 2017-06-01 | 2018-12-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾロキノリン誘導体とメマンチンの併用による認知症治療剤 |
| RU2019135834A (ru) | 2017-06-01 | 2021-07-13 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Терапевтическое средство для лечения деменции, представляющее собой комбинацию производного пиразолохинолина и донепезила |
| BR112019023552A2 (pt) | 2017-06-01 | 2020-06-02 | Eisai R&D Management Co., Ltd. | Agente terapêutico para a demência com corpos de lewy contendo derivado de pirazoloquinolina |
| KR20200010211A (ko) | 2017-06-01 | 2020-01-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Pde9 저해제를 포함하는 약제학적 조성물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1161281B (de) | 1960-05-11 | 1964-01-16 | Ciba Aktiengesellschaft, Basel (Schweiz) | Verfahren zur Herstellung von 1-Alkyl-6-aralkyl-pyrazoloÄ3,4-dÜ-pyrimidinen. |
| DE1147234B (de) | 1960-05-11 | 1963-04-18 | Ciba Geigy | Verfahren zur Herstellung von 1-Isopropyl-4-hydroxy-6-benzyl-pyrazolo[3, 4-d]pyrimidin |
| CH396926A (de) | 1960-05-11 | 1965-08-15 | Ciba Geigy | Verfahren zur Herstellung neuer Pyrazolopyrimidine |
| CH396927A (de) | 1960-05-11 | 1965-08-15 | Ciba Geigy | Verfahren zur Herstellung neuer Pyrazolopyrimidine |
| DE1149013B (de) | 1960-05-11 | 1963-05-22 | Ciba Geigy | Verfahren zur Herstellung von 4-Oxo-4, 5-dihydro-pyrazolo-[3, 4-d]Pyrimidinen |
| CH396925A (de) | 1960-05-11 | 1965-08-15 | Ciba Geigy | Verfahren zur Herstellung neuer Pyrazolopyrimidine |
| CH396924A (de) | 1960-05-11 | 1965-08-15 | Ciba Geigy | Verfahren zur Herstellung von 4-Mercapto-pyrazolo(3,4-d)pyrimidinen |
| US3732225A (en) | 1970-07-23 | 1973-05-08 | Squibb & Sons Inc | Pyrazolo(3,4-d)pyrimidine derivatives |
| US3847908A (en) | 1973-03-05 | 1974-11-12 | Squibb & Sons Inc | 6-styrylpyrazolo(3,4-d)pyrimidinones and pyrimidines |
| ES2077591T3 (es) | 1989-01-26 | 1995-12-01 | Bayer Ag | Derivados de acido (met)acrilico opticamente activos, su fabricacion, su polimerizacion para dar polimeros opticamente activos y su uso. |
| RU2104216C1 (ru) * | 1994-01-10 | 1998-02-10 | Акционерное общество открытого типа "Таганрогский авиационный научно-технический комплекс им.Г.М.Бериева" | Замок |
| DE19709877A1 (de) | 1997-03-11 | 1998-09-17 | Bayer Ag | 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate |
| WO2002009713A2 (de) * | 2000-08-01 | 2002-02-07 | Bayer Aktiengesellschaft | Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung |
| HN2002000317A (es) * | 2001-11-02 | 2003-05-21 | Pfizer | Inhibidores de pde9 para tratamiento de trastornos cardiovasculares |
| EP1444009A1 (en) * | 2001-11-02 | 2004-08-11 | Pfizer Products Inc. | Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors |
| DE10219435A1 (de) * | 2002-05-02 | 2003-11-13 | Bayer Cropscience Ag | Substituierte Pyrazolo-pyrimidin-4-one |
-
2004
- 2004-01-28 DE DE102004004142A patent/DE102004004142A1/de not_active Withdrawn
- 2004-04-28 RU RU2005138339/04A patent/RU2383546C2/ru not_active IP Right Cessation
- 2004-04-28 NZ NZ543812A patent/NZ543812A/en not_active IP Right Cessation
- 2004-04-28 EP EP10186283.7A patent/EP2298773B1/de not_active Expired - Lifetime
- 2004-05-07 PE PE2004000472A patent/PE20050201A1/es not_active Application Discontinuation
- 2004-05-07 MY MYPI20041687A patent/MY148252A/en unknown
- 2004-05-07 TW TW093112841A patent/TWI350836B/zh not_active IP Right Cessation
- 2004-05-07 CL CL200400978A patent/CL2004000978A1/es unknown
-
2011
- 2011-11-08 JP JP2011244500A patent/JP5277303B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012036221A (ja) | 2012-02-23 |
| JP5277303B2 (ja) | 2013-08-28 |
| RU2383546C2 (ru) | 2010-03-10 |
| EP2298773B1 (de) | 2013-06-19 |
| CL2004000978A1 (es) | 2005-03-18 |
| MY148252A (en) | 2013-03-29 |
| TW200508237A (en) | 2005-03-01 |
| NZ543812A (en) | 2010-06-25 |
| TWI350836B (en) | 2011-10-21 |
| DE102004004142A1 (de) | 2004-11-25 |
| EP2298773A1 (de) | 2011-03-23 |
| RU2005138339A (ru) | 2006-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |