KR840008155A - 트리아조로[4,3,-c] 피리미딘과 트리아조로[1,5-c]피리미딘의 제조방법 - Google Patents
트리아조로[4,3,-c] 피리미딘과 트리아조로[1,5-c]피리미딘의 제조방법 Download PDFInfo
- Publication number
- KR840008155A KR840008155A KR1019840001076A KR840001076A KR840008155A KR 840008155 A KR840008155 A KR 840008155A KR 1019840001076 A KR1019840001076 A KR 1019840001076A KR 840001076 A KR840001076 A KR 840001076A KR 840008155 A KR840008155 A KR 840008155A
- Authority
- KR
- South Korea
- Prior art keywords
- hydrogen
- lower alkyl
- pyrimidine
- phenyl
- triazolo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 하기식(ⅠA)화합물의 유효량과 약학적 유용부형제(賦形劑)를 함유하는 약제학적 조성물.여기에서, R3는 수소 또는 저급알킬, R5와 R7는 헤테로사이클릭치환분(X는 수소, 황, 설피닐, 설포닐, 메틸렌, 이미도 또는 N-저급알킬이미도),R5가 헤테로사이클릭치환분일 때 R7는 수소 또는 저급알킬; R5이 헤테로사이클릭치환분일 때 R7는 수소, 저급알킬티오, 페닐 또는저급알킬; R8는 수소, 페닐 또는 저급알킬, 또는 그것의 약학적 유용염이다.
- 하기식(ⅠB) 화합물의 유효량과 약학적 유용부형제를 함유하는 약제학적 조성물.여기에서, R2는 수소 또는 저급알킬, R5와 R7중 최소한 하나가(각각 X는 서로 다르게 산소, 황, 설피닐, 설포닐, 메틸렌, 이미도 또는 저급 N-알킬이미도); R5와 R7중 하나는 또한 수소 또는 저급알킬일 수 있다; R8는 수소, 저급알킬 또는 페닐; 또는 그것의 약학적 유용염이다.
- 하기식(Ⅰa)의 트리아조로[4,3-c] 피리미딘을 수성산 존재하에서 가열시켜 하기식(Ⅰb)의 트리아조로 [1,5-c] 피리미딘을 생산하는 제조방법.여기에서, R2는 수소 또는 저급알킬; R5는 수소, 저급알킬 또는 페닐; R는 수소, 저급알킬 또는 페닐, X는 수소, 황, 설피닐, 설포닐, 메틸렌, 이미도 또는 N-저급알킬이미도이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019900009371A KR920000271B1 (ko) | 1983-03-03 | 1990-06-25 | 1,2,4-트리아조로[1,5-c] 피리미딘 및 이의 제조방법 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US471837 | 1983-03-03 | ||
US06/471,837 US4477450A (en) | 1983-03-03 | 1983-03-03 | Triazolo [4,3-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
US06/471,836 US4572910A (en) | 1983-03-03 | 1983-03-03 | Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
US471836 | 1983-03-03 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900009371A Division KR920000271B1 (ko) | 1983-03-03 | 1990-06-25 | 1,2,4-트리아조로[1,5-c] 피리미딘 및 이의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840008155A true KR840008155A (ko) | 1984-12-13 |
KR900005836B1 KR900005836B1 (ko) | 1990-08-13 |
Family
ID=23873174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840001076A KR900005836B1 (ko) | 1983-03-03 | 1984-03-03 | 1,2,4-트리아조로[4,3-c]피리미딘 |
Country Status (4)
Country | Link |
---|---|
US (1) | US4572910A (ko) |
JP (1) | JPS59167592A (ko) |
KR (1) | KR900005836B1 (ko) |
ZA (1) | ZA841603B (ko) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4612375A (en) * | 1983-05-02 | 1986-09-16 | Riker Laboratories, Inc. | Substituted 4-hydrazino-pyrimides as intermediates for triazolo [4,3-c]pyrimidines |
US4734413A (en) * | 1987-03-02 | 1988-03-29 | Riker Laboratories, Inc. | Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators |
US5089493A (en) * | 1988-02-05 | 1992-02-18 | Riker Laboratories, Inc. | Triazolo[1,5-C]pyrimido[1,4]azines as bronchodilators |
US4981850A (en) * | 1988-02-05 | 1991-01-01 | Riker Laboratories, Inc. | Triazolo[1,5-c]pyrimido[1,4]azines as bronchodilators |
US5166343A (en) * | 1988-02-05 | 1992-11-24 | Riker Laboratories, Inc. | Triazolo[1,5-c]pyrimido[1,4]-azines as bronchodilators |
CA1331178C (en) * | 1988-02-05 | 1994-08-02 | James J. Wade | Triazolo ¬1,5-c| pyrimido ¬1,4| azines as bronchodilators |
FR2678618B1 (fr) * | 1991-07-05 | 1993-11-05 | Upsa Laboratoires | Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
IL108747A (en) * | 1993-03-04 | 1999-03-12 | Shell Int Research | Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation |
CA2284737C (en) | 1997-03-24 | 2007-03-13 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]triazolo[1,5-c]pyrimidine derivatives |
CN1328560A (zh) | 1998-09-22 | 2001-12-26 | 协和发酵工业株式会社 | [1,2,4]三唑并[1,5-c]嘧啶衍生物 |
JPWO2004029056A1 (ja) * | 2002-09-24 | 2006-01-26 | 協和醗酵工業株式会社 | [1,2,4]トリアゾロ[1,5−c]ピリミジン誘導体 |
DE102004027871B3 (de) * | 2004-06-08 | 2006-03-16 | Lanxess Deutschland Gmbh | Verfahren zur Herstellung von 10α-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-desoxo-10-dihydroartemisinin |
US10301289B2 (en) * | 2012-05-08 | 2019-05-28 | Bayer Pharma Aktiengesellschaft | Method for the preparation of triazole compounds |
GB201504565D0 (en) * | 2015-03-18 | 2015-05-06 | Takeda Pharmaceutical | Novel compounds |
CA3135449A1 (en) * | 2019-04-03 | 2020-10-08 | Tera Stone Co., Ltd | Triazolopyrimidines based on thymine nucleobase and methods for producing them |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1205144A (fr) * | 1957-06-14 | 1960-01-29 | Farmaceutici Italia | Procédé pour la synthèse de 7-méthyl-s. triazol (4, 3-c) pyrimidines substituéesen position 5 |
GB859287A (en) * | 1958-10-03 | 1961-01-18 | Ici Ltd | Triazolopyrimidine derivatives and their preparation |
GB873223A (en) * | 1959-04-13 | 1961-07-19 | Ici Ltd | Heterocyclic compounds |
GB897870A (en) * | 1959-06-15 | 1962-05-30 | Ici Ltd | s-triazolo[2, 3-c]pyrimidine derivatives |
GB898409A (en) * | 1960-02-29 | 1962-06-06 | Ici Ltd | Process for the manufacture of 2-amino-ú=-triazolo[2,3-c]pyrimidines |
US4269980A (en) * | 1979-12-17 | 1981-05-26 | American Cyanamid Company | (Substituted-phenyl)-1,2,4-triazolo[4,3-c]pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-c]pyrimidines |
-
1983
- 1983-03-03 US US06/471,836 patent/US4572910A/en not_active Expired - Fee Related
-
1984
- 1984-03-02 ZA ZA841603A patent/ZA841603B/xx unknown
- 1984-03-02 JP JP59040265A patent/JPS59167592A/ja active Pending
- 1984-03-03 KR KR1019840001076A patent/KR900005836B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR900005836B1 (ko) | 1990-08-13 |
US4572910A (en) | 1986-02-25 |
JPS59167592A (ja) | 1984-09-21 |
ZA841603B (en) | 1986-01-29 |
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