KR840008155A - 트리아조로[4,3,-c] 피리미딘과 트리아조로[1,5-c]피리미딘의 제조방법 - Google Patents

트리아조로[4,3,-c] 피리미딘과 트리아조로[1,5-c]피리미딘의 제조방법 Download PDF

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Publication number
KR840008155A
KR840008155A KR1019840001076A KR840001076A KR840008155A KR 840008155 A KR840008155 A KR 840008155A KR 1019840001076 A KR1019840001076 A KR 1019840001076A KR 840001076 A KR840001076 A KR 840001076A KR 840008155 A KR840008155 A KR 840008155A
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KR
South Korea
Prior art keywords
hydrogen
lower alkyl
pyrimidine
phenyl
triazolo
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Application number
KR1019840001076A
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English (en)
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KR900005836B1 (ko
Inventor
죠셉웨이드 제임스
Original Assignee
로날드 올리버보콜
라이커 레보러토리즈, 인코오포레이티드
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Priority claimed from US06/471,837 external-priority patent/US4477450A/en
Application filed by 로날드 올리버보콜, 라이커 레보러토리즈, 인코오포레이티드 filed Critical 로날드 올리버보콜
Publication of KR840008155A publication Critical patent/KR840008155A/ko
Priority to KR1019900009371A priority Critical patent/KR920000271B1/ko
Application granted granted Critical
Publication of KR900005836B1 publication Critical patent/KR900005836B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음.

Description

트리아조로[4,3-c] 피리미딘과 트리아조로[1,5-c]피리미딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기식(ⅠA)화합물의 유효량과 약학적 유용부형제(賦形劑)를 함유하는 약제학적 조성물.
    여기에서, R3는 수소 또는 저급알킬, R5와 R7는 헤테로사이클릭치환분(X는 수소, 황, 설피닐, 설포닐, 메틸렌, 이미도 또는 N-저급알킬이미도),R5가 헤테로사이클릭치환분일 때 R7는 수소 또는 저급알킬; R5이 헤테로사이클릭치환분일 때 R7는 수소, 저급알킬티오, 페닐 또는저급알킬; R8는 수소, 페닐 또는 저급알킬, 또는 그것의 약학적 유용염이다.
  2. 하기식(ⅠB) 화합물의 유효량과 약학적 유용부형제를 함유하는 약제학적 조성물.
    여기에서, R2는 수소 또는 저급알킬, R5와 R7중 최소한 하나가(각각 X는 서로 다르게 산소, 황, 설피닐, 설포닐, 메틸렌, 이미도 또는 저급 N-알킬이미도); R5와 R7중 하나는 또한 수소 또는 저급알킬일 수 있다; R8는 수소, 저급알킬 또는 페닐; 또는 그것의 약학적 유용염이다.
  3. 하기식(Ⅰa)의 트리아조로[4,3-c] 피리미딘을 수성산 존재하에서 가열시켜 하기식(Ⅰb)의 트리아조로 [1,5-c] 피리미딘을 생산하는 제조방법.
    여기에서, R2는 수소 또는 저급알킬; R5는 수소, 저급알킬 또는 페닐; R는 수소, 저급알킬 또는 페닐, X는 수소, 황, 설피닐, 설포닐, 메틸렌, 이미도 또는 N-저급알킬이미도이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840001076A 1983-03-03 1984-03-03 1,2,4-트리아조로[4,3-c]피리미딘 KR900005836B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019900009371A KR920000271B1 (ko) 1983-03-03 1990-06-25 1,2,4-트리아조로[1,5-c] 피리미딘 및 이의 제조방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US471837 1983-03-03
US06/471,837 US4477450A (en) 1983-03-03 1983-03-03 Triazolo [4,3-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US06/471,836 US4572910A (en) 1983-03-03 1983-03-03 Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US471836 1983-03-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019900009371A Division KR920000271B1 (ko) 1983-03-03 1990-06-25 1,2,4-트리아조로[1,5-c] 피리미딘 및 이의 제조방법

Publications (2)

Publication Number Publication Date
KR840008155A true KR840008155A (ko) 1984-12-13
KR900005836B1 KR900005836B1 (ko) 1990-08-13

Family

ID=23873174

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001076A KR900005836B1 (ko) 1983-03-03 1984-03-03 1,2,4-트리아조로[4,3-c]피리미딘

Country Status (4)

Country Link
US (1) US4572910A (ko)
JP (1) JPS59167592A (ko)
KR (1) KR900005836B1 (ko)
ZA (1) ZA841603B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612375A (en) * 1983-05-02 1986-09-16 Riker Laboratories, Inc. Substituted 4-hydrazino-pyrimides as intermediates for triazolo [4,3-c]pyrimidines
US4734413A (en) * 1987-03-02 1988-03-29 Riker Laboratories, Inc. Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators
US5089493A (en) * 1988-02-05 1992-02-18 Riker Laboratories, Inc. Triazolo[1,5-C]pyrimido[1,4]azines as bronchodilators
US4981850A (en) * 1988-02-05 1991-01-01 Riker Laboratories, Inc. Triazolo[1,5-c]pyrimido[1,4]azines as bronchodilators
US5166343A (en) * 1988-02-05 1992-11-24 Riker Laboratories, Inc. Triazolo[1,5-c]pyrimido[1,4]-azines as bronchodilators
CA1331178C (en) * 1988-02-05 1994-08-02 James J. Wade Triazolo ¬1,5-c| pyrimido ¬1,4| azines as bronchodilators
FR2678618B1 (fr) * 1991-07-05 1993-11-05 Upsa Laboratoires Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
IL108747A (en) * 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
CA2284737C (en) 1997-03-24 2007-03-13 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]triazolo[1,5-c]pyrimidine derivatives
CN1328560A (zh) 1998-09-22 2001-12-26 协和发酵工业株式会社 [1,2,4]三唑并[1,5－c]嘧啶衍生物
JPWO2004029056A1 (ja) * 2002-09-24 2006-01-26 協和醗酵工業株式会社 ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
DE102004027871B3 (de) * 2004-06-08 2006-03-16 Lanxess Deutschland Gmbh Verfahren zur Herstellung von 10α-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-desoxo-10-dihydroartemisinin
US10301289B2 (en) * 2012-05-08 2019-05-28 Bayer Pharma Aktiengesellschaft Method for the preparation of triazole compounds
GB201504565D0 (en) * 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
CA3135449A1 (en) * 2019-04-03 2020-10-08 Tera Stone Co., Ltd Triazolopyrimidines based on thymine nucleobase and methods for producing them

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1205144A (fr) * 1957-06-14 1960-01-29 Farmaceutici Italia Procédé pour la synthèse de 7-méthyl-s. triazol (4, 3-c) pyrimidines substituéesen position 5
GB859287A (en) * 1958-10-03 1961-01-18 Ici Ltd Triazolopyrimidine derivatives and their preparation
GB873223A (en) * 1959-04-13 1961-07-19 Ici Ltd Heterocyclic compounds
GB897870A (en) * 1959-06-15 1962-05-30 Ici Ltd s-triazolo[2, 3-c]pyrimidine derivatives
GB898409A (en) * 1960-02-29 1962-06-06 Ici Ltd Process for the manufacture of 2-amino-ú=-triazolo[2,3-c]pyrimidines
US4269980A (en) * 1979-12-17 1981-05-26 American Cyanamid Company (Substituted-phenyl)-1,2,4-triazolo[4,3-c]pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-c]pyrimidines

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KR900005836B1 (ko) 1990-08-13
US4572910A (en) 1986-02-25
JPS59167592A (ja) 1984-09-21
ZA841603B (en) 1986-01-29

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