PE20050201A1 - Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetilo - Google Patents

Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetilo

Info

Publication number
PE20050201A1
PE20050201A1 PE2004000472A PE2004000472A PE20050201A1 PE 20050201 A1 PE20050201 A1 PE 20050201A1 PE 2004000472 A PE2004000472 A PE 2004000472A PE 2004000472 A PE2004000472 A PE 2004000472A PE 20050201 A1 PE20050201 A1 PE 20050201A1
Authority
PE
Peru
Prior art keywords
pyrazole
methylphenyl
alkyl
cyclylmethyl
alkylmethyl
Prior art date
Application number
PE2004000472A
Other languages
English (en)
Spanish (es)
Inventor
Martin Hendrix
Lars Barfacker
Frank-Thorsten Hafner
Dagmar Schaub
Der Staay Franz-Josef Van
Kampen Marja Van
Adrian Tersteegen
Heike Heckroth
Christina Erb
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20050201A1 publication Critical patent/PE20050201A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PE2004000472A 2003-05-09 2004-05-07 Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetilo PE20050201A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10320784 2003-05-09
DE10336183 2003-08-07
DE102004004142A DE102004004142A1 (de) 2003-05-09 2004-01-28 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine

Publications (1)

Publication Number Publication Date
PE20050201A1 true PE20050201A1 (es) 2005-05-27

Family

ID=33420016

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000472A PE20050201A1 (es) 2003-05-09 2004-05-07 Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetilo

Country Status (9)

Country Link
EP (1) EP2298773B1 (enExample)
JP (1) JP5277303B2 (enExample)
CL (1) CL2004000978A1 (enExample)
DE (1) DE102004004142A1 (enExample)
MY (1) MY148252A (enExample)
NZ (1) NZ543812A (enExample)
PE (1) PE20050201A1 (enExample)
RU (1) RU2383546C2 (enExample)
TW (1) TWI350836B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20151718A1 (es) * 2013-04-05 2015-11-22 Eisai Randd Man Co Ltd Compuestos piridinilpirazoloquinolina
IL270394B (en) 2017-06-01 2022-08-01 Eisai R&D Man Co Ltd Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine
CA3061884A1 (en) 2017-06-01 2019-10-29 Eisai R&D Management Co., Ltd. Lewy body disease therapeutic agent containing pyrazoloquinoline derivative
CN110545812A (zh) 2017-06-01 2019-12-06 卫材R&D管理有限公司 包含pde9抑制剂的药物组合物
SG11201909595VA (en) 2017-06-01 2019-11-28 Eisai R&D Man Co Ltd Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH396927A (de) 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
CH396926A (de) 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
DE1161281B (de) 1960-05-11 1964-01-16 Ciba Aktiengesellschaft, Basel (Schweiz) Verfahren zur Herstellung von 1-Alkyl-6-aralkyl-pyrazoloÄ3,4-dÜ-pyrimidinen.
CH396925A (de) * 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
CH396924A (de) 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung von 4-Mercapto-pyrazolo(3,4-d)pyrimidinen
DE1147234B (de) 1960-05-11 1963-04-18 Ciba Geigy Verfahren zur Herstellung von 1-Isopropyl-4-hydroxy-6-benzyl-pyrazolo[3, 4-d]pyrimidin
DE1149013B (de) 1960-05-11 1963-05-22 Ciba Geigy Verfahren zur Herstellung von 4-Oxo-4, 5-dihydro-pyrazolo-[3, 4-d]Pyrimidinen
US3732225A (en) 1970-07-23 1973-05-08 Squibb & Sons Inc Pyrazolo(3,4-d)pyrimidine derivatives
US3847908A (en) 1973-03-05 1974-11-12 Squibb & Sons Inc 6-styrylpyrazolo(3,4-d)pyrimidinones and pyrimidines
DE59009485D1 (de) 1989-01-26 1995-09-14 Bayer Ag Optisch aktive (Meth)Acrylsäure-Derivate, ihre Herstellung, ihre Polymerisation zu optisch aktiven Polymeren und deren Verwendung.
RU2104216C1 (ru) * 1994-01-10 1998-02-10 Акционерное общество открытого типа "Таганрогский авиационный научно-технический комплекс им.Г.М.Бериева" Замок
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
WO2002009713A2 (de) * 2000-08-01 2002-02-07 Bayer Aktiengesellschaft Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
HN2002000317A (es) * 2001-11-02 2003-05-21 Pfizer Inhibidores de pde9 para tratamiento de trastornos cardiovasculares
JP2005508978A (ja) * 2001-11-02 2005-04-07 ファイザー・プロダクツ・インク Ｐｄｅ９阻害薬によるインスリン抵抗性症候群及び２型糖尿病の治療
DE10219435A1 (de) * 2002-05-02 2003-11-13 Bayer Cropscience Ag Substituierte Pyrazolo-pyrimidin-4-one

Also Published As

Publication number Publication date
MY148252A (en) 2013-03-29
CL2004000978A1 (es) 2005-03-18
DE102004004142A1 (de) 2004-11-25
TWI350836B (en) 2011-10-21
JP5277303B2 (ja) 2013-08-28
EP2298773B1 (de) 2013-06-19
EP2298773A1 (de) 2011-03-23
RU2005138339A (ru) 2006-08-10
NZ543812A (en) 2010-06-25
TW200508237A (en) 2005-03-01
JP2012036221A (ja) 2012-02-23
RU2383546C2 (ru) 2010-03-10

Similar Documents

Publication Publication Date Title
PE20001419A1 (es) COMPLEJO DEL INHIBIDOR DE RAS-FARNESILTRANSFERASA Y SULFOBUTILETER-7-ß-CICLODEXTRINA O 2-HIDROXIPROPIL-ß-CICLODEXTRINA Y METODO
PE20080139A1 (es) Compuestos de pirrolotriazina anilina como inhibidores de cinasa
ATE273961T1 (de) Verfahren zur herstellung von 4- trifluormethylsulfinylpyrazolderivat
ECSP034707A (es) Derivados de urea como antagonistas de alfa integrado
PE20050679A1 (es) Compuestos de pirrolotriazina como inhibidores de la cinasa
PE20020470A1 (es) Derivados de pirazol como inhibidores de las enzimas proteina quinasas
CR8302A (es) Compuestos heterociclicos fusionados
PE20120121A1 (es) Derivados de imidazopirazina como inhibidores de syk
PE20050072A1 (es) Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf)
DE60330800D1 (de) Verfahren zur herstellung von pyrrolotriazinverbindungen, die sich als kinaseinhibitoren eignen
DE502004005772D1 (de) Verfahren zur herstellung von 3-phenyl(thio)uracilen und 3-phenyldithiouracilen
PE20040071A1 (es) Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion
PE20080059A1 (es) Quinazolinas para la inhibicion de pdk1
PE20110009A1 (es) Derivados de pirrol como inhibidores de la secrecion acida
Brown Fused Pyrimidines, Volume 24, Part 3: Pteridines
AR104918A1 (es) Procesos e intermediarios para la preparación de {1-(etilsulfonil)-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrilo
YU50002A (sh) Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju
PE20051171A1 (es) Inhibidores de proteina quinasas con estructura de 3-quinolincarbonitrilo
ES8505997A1 (es) Un procedimiento para la preparacion de dihidropiridinas
DE60205769D1 (de) Verfahren zur herstellung von amphetaminen aus phenylpropanolaminen
KR840008155A (ko) 트리아조로[4,3,-c] 피리미딘과 트리아조로[1,5-c]피리미딘의 제조방법
ATE465159T1 (de) (s)-(-)-1-(4-fluorisochinolin-5-yl)sulfonyl-2- methyl-1,4-homopiperazinhydrochlorid- dihydrat
DE3882895D1 (de) Imid-derivate, ihre herstellung und verwendung.
PE20040905A1 (es) Derivados biciclicos como inhibidores de tirosina quinasa
ATE300522T1 (de) Cyclisierungsverfahrensschritt bei der herstellung von chinolonen und naphthyridinen

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed