GT200400088A - Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetilo - Google Patents

Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetilo

Info

Publication number
GT200400088A
GT200400088A GT200400088A GT200400088A GT200400088A GT 200400088 A GT200400088 A GT 200400088A GT 200400088 A GT200400088 A GT 200400088A GT 200400088 A GT200400088 A GT 200400088A GT 200400088 A GT200400088 A GT 200400088A
Authority
GT
Guatemala
Prior art keywords
pirazolopirimidines
cyclilmetilo
alquilmetilo
replaced
training
Prior art date
Application number
GT200400088A
Other languages
English (en)
Inventor
Martin Hendrix
Lars Baerfacker
Christina Erb
Frank-Thorsten Hafner
Heike Heckroth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200400088A publication Critical patent/GT200400088A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA GENERAL I EN LA QUE R1,R2,SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS VAN A INHIBIR A LAS FOSFODIESTERASAS QUE SON LAS QUE MODULAN EL NIVEL DE LOS NUCLEOTIDOS CICLICOS AMPC Y GMPC POR LO QUE SON DE UTILIDAD EN UNA AMPLIA VARIEDAD DE PATOLOGIAS TALES COMO LOS RELACIONADOS A LA PERCEPCION, CAPACIDAD DE CONCENTRACION, CAPACIDAD DE APRENDIZAJE Y/O MEMORIA.
GT200400088A 2003-05-09 2004-05-04 Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetilo GT200400088A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10320784 2003-05-09

Publications (1)

Publication Number Publication Date
GT200400088A true GT200400088A (es) 2004-12-16

Family

ID=38004610

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200400088A GT200400088A (es) 2003-05-09 2004-05-04 Pirazolopirimidinas sustituidas con 6-ciclilmetilo y 6-alquilmetilo

Country Status (3)

Country Link
US (3) US8044060B2 (es)
GT (1) GT200400088A (es)
ZA (1) ZA200509884B (es)

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DE10320785A1 (de) 2003-05-09 2004-11-25 Bayer Healthcare Ag 6-Arylmethyl-substituierte Pyrazolopyrimidine
DE10328479A1 (de) * 2003-06-25 2005-01-13 Bayer Ag 6-Arylamino-5-cyano-4-pyrimidinone
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NZ590788A (en) 2008-09-08 2012-11-30 Boehringer Ingelheim Int Pyrazolopyrimidines and their use for the treatment of cns disorders
ES2460019T3 (es) 2009-03-31 2014-05-13 Boehringer Ingelheim International Gmbh Derivados de 1-heterociclil-1,5-dihidro-pirazolo[3,4-d]pirimidin-4-ona y su uso como moduladores de PDE9A
AR077859A1 (es) * 2009-08-12 2011-09-28 Boehringer Ingelheim Int Compuestos para el tratamiento de trastornos del snc
HUE033378T2 (en) * 2010-08-12 2017-11-28 Boehringer Ingelheim Int 6-Cycloalkyl-1,5-dihydro-pyrazolo [3,4-D] pyrimidin-4-one and their use as PDE9A inhibitors
US20130040971A1 (en) * 2011-02-14 2013-02-14 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of cns disorders
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
MX2015016029A (es) * 2013-05-28 2016-03-21 Bayer Cropscience Ag Compuestos heterociclicos como agentes para control de plagas.

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Also Published As

Publication number Publication date
US20110065730A1 (en) 2011-03-17
US20070105876A1 (en) 2007-05-10
ZA200509884B (en) 2007-06-27
US8642605B2 (en) 2014-02-04
US8822479B2 (en) 2014-09-02
US20120010224A1 (en) 2012-01-12
US8044060B2 (en) 2011-10-25

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