TWI350836B - 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines - Google Patents

6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines

Info

Publication number
TWI350836B
TWI350836B TW093112841A TW93112841A TWI350836B TW I350836 B TWI350836 B TW I350836B TW 093112841 A TW093112841 A TW 093112841A TW 93112841 A TW93112841 A TW 93112841A TW I350836 B TWI350836 B TW I350836B
Authority
TW
Taiwan
Prior art keywords
cyclylmethyl
alkylmethyl
substituted pyrazolopyrimidines
pyrazolopyrimidines
substituted
Prior art date
Application number
TW093112841A
Other languages
English (en)
Chinese (zh)
Other versions
TW200508237A (en
Inventor
Martin Hendrix
Lars Barfacker
Christina Erb
Frank-Thorsten Hafner
Heike Heckroth
Dagmar Schaub
Adrian Tersteegen
Der Staay Franz-Josef Van
Kampen Marja Van
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TW200508237A publication Critical patent/TW200508237A/zh
Application granted granted Critical
Publication of TWI350836B publication Critical patent/TWI350836B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW093112841A 2003-05-09 2004-05-07 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines TWI350836B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10320784 2003-05-09
DE10336183 2003-08-07
DE102004004142A DE102004004142A1 (de) 2003-05-09 2004-01-28 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine

Publications (2)

Publication Number Publication Date
TW200508237A TW200508237A (en) 2005-03-01
TWI350836B true TWI350836B (en) 2011-10-21

Family

ID=33420016

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093112841A TWI350836B (en) 2003-05-09 2004-05-07 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines

Country Status (9)

Country Link
EP (1) EP2298773B1 (enExample)
JP (1) JP5277303B2 (enExample)
CL (1) CL2004000978A1 (enExample)
DE (1) DE102004004142A1 (enExample)
MY (1) MY148252A (enExample)
NZ (1) NZ543812A (enExample)
PE (1) PE20050201A1 (enExample)
RU (1) RU2383546C2 (enExample)
TW (1) TWI350836B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2904820C (en) * 2013-04-05 2021-05-18 Eisai R&D Management Co., Ltd. Pyridinylpyrazoloquinoline compound
SG11201909359YA (en) 2017-06-01 2019-11-28 Eisai R&D Man Co Ltd Pharmaceutical composition comprising pde9 inhibitor
WO2018221550A1 (ja) 2017-06-01 2018-12-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロキノリン誘導体とメマンチンの併用による認知症治療剤
JP7269875B2 (ja) 2017-06-01 2023-05-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロキノリン誘導体を含有するレビー小体病治療剤
RU2019135834A (ru) 2017-06-01 2021-07-13 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Терапевтическое средство для лечения деменции, представляющее собой комбинацию производного пиразолохинолина и донепезила

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH396927A (de) 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
DE1147234B (de) 1960-05-11 1963-04-18 Ciba Geigy Verfahren zur Herstellung von 1-Isopropyl-4-hydroxy-6-benzyl-pyrazolo[3, 4-d]pyrimidin
DE1161281B (de) 1960-05-11 1964-01-16 Ciba Aktiengesellschaft, Basel (Schweiz) Verfahren zur Herstellung von 1-Alkyl-6-aralkyl-pyrazoloÄ3,4-dÜ-pyrimidinen.
CH396925A (de) * 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
DE1149013B (de) 1960-05-11 1963-05-22 Ciba Geigy Verfahren zur Herstellung von 4-Oxo-4, 5-dihydro-pyrazolo-[3, 4-d]Pyrimidinen
CH396924A (de) 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung von 4-Mercapto-pyrazolo(3,4-d)pyrimidinen
CH396926A (de) 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
US3732225A (en) 1970-07-23 1973-05-08 Squibb & Sons Inc Pyrazolo(3,4-d)pyrimidine derivatives
US3847908A (en) 1973-03-05 1974-11-12 Squibb & Sons Inc 6-styrylpyrazolo(3,4-d)pyrimidinones and pyrimidines
DE59009485D1 (de) 1989-01-26 1995-09-14 Bayer Ag Optisch aktive (Meth)Acrylsäure-Derivate, ihre Herstellung, ihre Polymerisation zu optisch aktiven Polymeren und deren Verwendung.
RU2104216C1 (ru) * 1994-01-10 1998-02-10 Акционерное общество открытого типа "Таганрогский авиационный научно-технический комплекс им.Г.М.Бериева" Замок
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
WO2002009713A2 (de) * 2000-08-01 2002-02-07 Bayer Aktiengesellschaft Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
HN2002000317A (es) * 2001-11-02 2003-05-21 Pfizer Inhibidores de pde9 para tratamiento de trastornos cardiovasculares
PL370599A1 (en) * 2001-11-02 2005-05-30 Pfizer Products Inc. Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors
DE10219435A1 (de) * 2002-05-02 2003-11-13 Bayer Cropscience Ag Substituierte Pyrazolo-pyrimidin-4-one

Also Published As

Publication number Publication date
PE20050201A1 (es) 2005-05-27
DE102004004142A1 (de) 2004-11-25
RU2383546C2 (ru) 2010-03-10
CL2004000978A1 (es) 2005-03-18
JP5277303B2 (ja) 2013-08-28
TW200508237A (en) 2005-03-01
RU2005138339A (ru) 2006-08-10
JP2012036221A (ja) 2012-02-23
EP2298773B1 (de) 2013-06-19
NZ543812A (en) 2010-06-25
MY148252A (en) 2013-03-29
EP2298773A1 (de) 2011-03-23

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Legal Events

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MM4A Annulment or lapse of patent due to non-payment of fees