TWI350836B - 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines - Google Patents

6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines

Info

Publication number
TWI350836B
TWI350836B TW093112841A TW93112841A TWI350836B TW I350836 B TWI350836 B TW I350836B TW 093112841 A TW093112841 A TW 093112841A TW 93112841 A TW93112841 A TW 93112841A TW I350836 B TWI350836 B TW I350836B
Authority
TW
Taiwan
Prior art keywords
cyclylmethyl
alkylmethyl
substituted pyrazolopyrimidines
pyrazolopyrimidines
substituted
Prior art date
Application number
TW093112841A
Other languages
English (en)
Chinese (zh)
Other versions
TW200508237A (en
Inventor
Martin Hendrix
Lars Barfacker
Christina Erb
Frank-Thorsten Hafner
Heike Heckroth
Dagmar Schaub
Adrian Tersteegen
Der Staay Franz-Josef Van
Kampen Marja Van
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of TW200508237A publication Critical patent/TW200508237A/zh
Application granted granted Critical
Publication of TWI350836B publication Critical patent/TWI350836B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW093112841A 2003-05-09 2004-05-07 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines TWI350836B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10320784 2003-05-09
DE10336183 2003-08-07
DE102004004142A DE102004004142A1 (de) 2003-05-09 2004-01-28 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine

Publications (2)

Publication Number Publication Date
TW200508237A TW200508237A (en) 2005-03-01
TWI350836B true TWI350836B (en) 2011-10-21

Family

ID=33420016

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093112841A TWI350836B (en) 2003-05-09 2004-05-07 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines

Country Status (9)

Country Link
EP (1) EP2298773B1 (enExample)
JP (1) JP5277303B2 (enExample)
CL (1) CL2004000978A1 (enExample)
DE (1) DE102004004142A1 (enExample)
MY (1) MY148252A (enExample)
NZ (1) NZ543812A (enExample)
PE (1) PE20050201A1 (enExample)
RU (1) RU2383546C2 (enExample)
TW (1) TWI350836B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20151718A1 (es) * 2013-04-05 2015-11-22 Eisai Randd Man Co Ltd Compuestos piridinilpirazoloquinolina
IL270394B (en) 2017-06-01 2022-08-01 Eisai R&D Man Co Ltd Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine
CA3061884A1 (en) 2017-06-01 2019-10-29 Eisai R&D Management Co., Ltd. Lewy body disease therapeutic agent containing pyrazoloquinoline derivative
CN110545812A (zh) 2017-06-01 2019-12-06 卫材R&D管理有限公司 包含pde9抑制剂的药物组合物
SG11201909595VA (en) 2017-06-01 2019-11-28 Eisai R&D Man Co Ltd Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH396927A (de) 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
CH396926A (de) 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
DE1161281B (de) 1960-05-11 1964-01-16 Ciba Aktiengesellschaft, Basel (Schweiz) Verfahren zur Herstellung von 1-Alkyl-6-aralkyl-pyrazoloÄ3,4-dÜ-pyrimidinen.
CH396925A (de) * 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
CH396924A (de) 1960-05-11 1965-08-15 Ciba Geigy Verfahren zur Herstellung von 4-Mercapto-pyrazolo(3,4-d)pyrimidinen
DE1147234B (de) 1960-05-11 1963-04-18 Ciba Geigy Verfahren zur Herstellung von 1-Isopropyl-4-hydroxy-6-benzyl-pyrazolo[3, 4-d]pyrimidin
DE1149013B (de) 1960-05-11 1963-05-22 Ciba Geigy Verfahren zur Herstellung von 4-Oxo-4, 5-dihydro-pyrazolo-[3, 4-d]Pyrimidinen
US3732225A (en) 1970-07-23 1973-05-08 Squibb & Sons Inc Pyrazolo(3,4-d)pyrimidine derivatives
US3847908A (en) 1973-03-05 1974-11-12 Squibb & Sons Inc 6-styrylpyrazolo(3,4-d)pyrimidinones and pyrimidines
DE59009485D1 (de) 1989-01-26 1995-09-14 Bayer Ag Optisch aktive (Meth)Acrylsäure-Derivate, ihre Herstellung, ihre Polymerisation zu optisch aktiven Polymeren und deren Verwendung.
RU2104216C1 (ru) * 1994-01-10 1998-02-10 Акционерное общество открытого типа "Таганрогский авиационный научно-технический комплекс им.Г.М.Бериева" Замок
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
WO2002009713A2 (de) * 2000-08-01 2002-02-07 Bayer Aktiengesellschaft Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
HN2002000317A (es) * 2001-11-02 2003-05-21 Pfizer Inhibidores de pde9 para tratamiento de trastornos cardiovasculares
JP2005508978A (ja) * 2001-11-02 2005-04-07 ファイザー・プロダクツ・インク Ｐｄｅ９阻害薬によるインスリン抵抗性症候群及び２型糖尿病の治療
DE10219435A1 (de) * 2002-05-02 2003-11-13 Bayer Cropscience Ag Substituierte Pyrazolo-pyrimidin-4-one

Also Published As

Publication number Publication date
MY148252A (en) 2013-03-29
CL2004000978A1 (es) 2005-03-18
PE20050201A1 (es) 2005-05-27
DE102004004142A1 (de) 2004-11-25
JP5277303B2 (ja) 2013-08-28
EP2298773B1 (de) 2013-06-19
EP2298773A1 (de) 2011-03-23
RU2005138339A (ru) 2006-08-10
NZ543812A (en) 2010-06-25
TW200508237A (en) 2005-03-01
JP2012036221A (ja) 2012-02-23
RU2383546C2 (ru) 2010-03-10

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees