PE20040686A1 - PROCESO ENANTIOSELECTIVO PARA LA PREPARACION DE AMBOS ENANTIOMEROS DE PROCESO ENANTIOSELECTIVO PARA LA PREPARACION DE AMBOS ENANTIOMEROS DE 10,11-DIHIDRO-10-HIDROXI-5H-DIBENZ[b,f]AZEPIN-5-CARBOXAMIDA - Google Patents

PROCESO ENANTIOSELECTIVO PARA LA PREPARACION DE AMBOS ENANTIOMEROS DE PROCESO ENANTIOSELECTIVO PARA LA PREPARACION DE AMBOS ENANTIOMEROS DE 10,11-DIHIDRO-10-HIDROXI-5H-DIBENZ[b,f]AZEPIN-5-CARBOXAMIDA

Info

Publication number
PE20040686A1
PE20040686A1 PE2003001022A PE2003001022A PE20040686A1 PE 20040686 A1 PE20040686 A1 PE 20040686A1 PE 2003001022 A PE2003001022 A PE 2003001022A PE 2003001022 A PE2003001022 A PE 2003001022A PE 20040686 A1 PE20040686 A1 PE 20040686A1
Authority
PE
Peru
Prior art keywords
preparation
azepin
carboxamide
hidroxi
dibenz
Prior art date
Application number
PE2003001022A
Other languages
English (en)
Spanish (es)
Inventor
Sabine Pfeffer
Gottfried Sedelmeier
Christian Mathes
Fritz Blatter
Dominique Grimler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20040686A1 publication Critical patent/PE20040686A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PE2003001022A 2002-10-07 2003-10-07 PROCESO ENANTIOSELECTIVO PARA LA PREPARACION DE AMBOS ENANTIOMEROS DE PROCESO ENANTIOSELECTIVO PARA LA PREPARACION DE AMBOS ENANTIOMEROS DE 10,11-DIHIDRO-10-HIDROXI-5H-DIBENZ[b,f]AZEPIN-5-CARBOXAMIDA PE20040686A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0223224.7A GB0223224D0 (en) 2002-10-07 2002-10-07 Organic compounds

Publications (1)

Publication Number Publication Date
PE20040686A1 true PE20040686A1 (es) 2004-10-29

Family

ID=9945425

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001022A PE20040686A1 (es) 2002-10-07 2003-10-07 PROCESO ENANTIOSELECTIVO PARA LA PREPARACION DE AMBOS ENANTIOMEROS DE PROCESO ENANTIOSELECTIVO PARA LA PREPARACION DE AMBOS ENANTIOMEROS DE 10,11-DIHIDRO-10-HIDROXI-5H-DIBENZ[b,f]AZEPIN-5-CARBOXAMIDA

Country Status (20)

Country Link
US (1) US20060142566A1 (cg-RX-API-DMAC10.html)
EP (1) EP1551808A1 (cg-RX-API-DMAC10.html)
JP (1) JP2006504710A (cg-RX-API-DMAC10.html)
KR (1) KR20050071549A (cg-RX-API-DMAC10.html)
CN (2) CN101062932A (cg-RX-API-DMAC10.html)
AR (1) AR041544A1 (cg-RX-API-DMAC10.html)
AU (1) AU2003276055B2 (cg-RX-API-DMAC10.html)
BR (1) BR0315113A (cg-RX-API-DMAC10.html)
CA (1) CA2501237A1 (cg-RX-API-DMAC10.html)
EC (1) ECSP055738A (cg-RX-API-DMAC10.html)
GB (1) GB0223224D0 (cg-RX-API-DMAC10.html)
HK (1) HK1079790A1 (cg-RX-API-DMAC10.html)
MX (1) MXPA05003737A (cg-RX-API-DMAC10.html)
NO (1) NO20052244L (cg-RX-API-DMAC10.html)
PE (1) PE20040686A1 (cg-RX-API-DMAC10.html)
PL (1) PL376379A1 (cg-RX-API-DMAC10.html)
RU (1) RU2005114350A (cg-RX-API-DMAC10.html)
TW (1) TW200413324A (cg-RX-API-DMAC10.html)
WO (1) WO2004031155A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200502561B (cg-RX-API-DMAC10.html)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0303615D0 (en) * 2003-02-17 2003-03-19 Novartis Ag Use of organic compounds
GB0425320D0 (en) 2004-11-17 2004-12-22 Johnson Matthey Plc Diamines
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0515690D0 (en) * 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB2437078A (en) * 2006-04-11 2007-10-17 Portela & Ca Sa 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives
JP5172124B2 (ja) * 2006-09-29 2013-03-27 関東化学株式会社 ２位に置換基を有する光学活性キヌクリジノール類の製造方法
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
WO2011045648A2 (en) * 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
EP2383261B1 (en) 2010-04-23 2013-09-04 Euticals GmbH Process for the asymmetric hydrogenation of ketones
CN102250005B (zh) * 2010-05-19 2015-04-08 浙江九洲药物科技有限公司 艾利西平的制备方法
ES2687678T3 (es) 2011-03-08 2018-10-26 Jubilant Life Sciences Limited Procedimiento para la preparación de (S)-(+)-10,11-dihidro-10-hidroxi-5H-dibenzo[b,f]azepina-5-carboxamida y ésteres de la misma mediante reducción enantioselectiva de 10,11-dihidro-10-oxo-5H-dibenzo[b,f]azepina-5-carboxamida
US9303038B2 (en) 2011-09-06 2016-04-05 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological diseases
JP2015522531A (ja) 2012-05-07 2015-08-06 セリックスビオ プライヴェート リミテッド 神経筋疾患及び神経変性疾患の治療のための組成物及び方法
WO2013167990A1 (en) 2012-05-07 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of depression
US9738631B2 (en) 2012-05-07 2017-08-22 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9266823B2 (en) 2012-05-08 2016-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of parkinson's disease
US9522884B2 (en) 2012-05-08 2016-12-20 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic disorders
US9403826B2 (en) 2012-05-08 2016-08-02 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory disorders
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
US9309233B2 (en) 2012-05-08 2016-04-12 Cellix Bio Private Limited Compositions and methods for the treatment of blood clotting disorders
WO2013168000A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of severe pain
US9242939B2 (en) 2012-05-10 2016-01-26 Cellix Bio Private Limited Compositions and methods for the treatment of respiratory disorders
US9321775B2 (en) 2012-05-10 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of moderate to severe pain
US9499527B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
WO2013168002A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurological conditions
US9339484B2 (en) 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US9315461B2 (en) 2012-05-10 2016-04-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
WO2013168015A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of asthma and allergy
SG11201407318UA (en) 2012-05-10 2014-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of metabolic syndrome
WO2013168004A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of fibromyalgia pain
WO2013167997A2 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic syndrome
WO2013168011A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of chronic pain
US9499526B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
WO2013175347A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
AU2013264820A1 (en) 2012-05-23 2014-11-27 Cellixbio Private Limited Compositions and methods for treatment of mucositis
US9498461B2 (en) 2012-05-23 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
AU2013264896A1 (en) 2012-05-23 2014-11-27 Cellixbio Private Limited Compositions and methods for the treatment of multiple sclerosis
WO2013175344A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
WO2013175376A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of local pain
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (en) 2012-08-03 2014-02-06 Mahesh Kandula Compositions and methods for the treatment migraine and neurologic diseases
US9624168B2 (en) 2012-09-06 2017-04-18 Cellix Bio Private Limited Compositions and methods for the treatment inflammation and lipid disorders
CA2873029A1 (en) 2012-09-08 2014-03-13 Cellixbio Private Limited Compositions and methods for the treatment of inflammation and lipid disorders
IN2015DN02296A (cg-RX-API-DMAC10.html) 2012-09-26 2015-08-21 Ranbaxy Lab Ltd
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
SG11201509782TA (en) 2013-06-04 2015-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of diabetes and pre-diabetes
US9029540B2 (en) * 2013-07-01 2015-05-12 Boehringer Ingelheim International Gmbh Ruthenium catalysts and their use for asymmetric reduction of ketones
CN103483257A (zh) * 2013-09-06 2014-01-01 江苏同禾药业有限公司 一种亚氨基芪的合成方法
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
EP3240779B1 (en) 2014-09-26 2020-10-28 Cellixbio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
ES2799309T3 (es) 2014-09-29 2020-12-16 Cellix Bio Private Ltd Compuestos y composiciones para el tratamiento de esclerosis múltiple
CA2965449C (en) 2014-10-27 2020-11-10 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
CN107207411A (zh) 2014-12-01 2017-09-26 塞尔利克斯生物私人有限公司 用于治疗多发性硬化的组合物和方法
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
ES2905771T3 (es) 2015-01-06 2022-04-12 Cellix Bio Private Ltd Composiciones y procedimientos para el tratamiento de la inflamación y del dolor
EP3064490A1 (en) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate
CN107033079B (zh) * 2016-10-17 2020-07-28 扬子江药业集团北京海燕药业有限公司 醋酸艾司利卡西平的制备方法
CN112679433B (zh) * 2019-10-18 2024-05-24 浙江九洲药业股份有限公司 一种艾利西平的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
CA2374553A1 (fr) * 1999-06-15 2000-12-21 Rhodia Chimie Sulfonylamides et carboxamides et leur application en catalyse asymetrique
ES2211373T1 (es) * 2001-02-12 2004-07-16 Teva Pharmaceutical Industries Ltd. Nuevas formas cristalinas de oxcarbazepina y procedimientos para su preparacion.

Also Published As

Publication number Publication date
CA2501237A1 (en) 2004-04-15
HK1079790A1 (zh) 2006-04-13
GB0223224D0 (en) 2002-11-13
PL376379A1 (en) 2005-12-27
TW200413324A (en) 2004-08-01
RU2005114350A (ru) 2006-01-20
US20060142566A1 (en) 2006-06-29
NO20052244L (no) 2005-07-07
BR0315113A (pt) 2005-08-23
CN101062932A (zh) 2007-10-31
ECSP055738A (es) 2005-07-06
KR20050071549A (ko) 2005-07-07
JP2006504710A (ja) 2006-02-09
ZA200502561B (en) 2006-02-22
AU2003276055B2 (en) 2008-01-03
NO20052244D0 (no) 2005-05-06
AU2003276055A1 (en) 2004-04-23
EP1551808A1 (en) 2005-07-13
MXPA05003737A (es) 2005-06-17
AR041544A1 (es) 2005-05-18
CN1703404A (zh) 2005-11-30
WO2004031155A1 (en) 2004-04-15

Similar Documents

Publication Publication Date Title
BR9809745A (pt) Sal cristalino de amina de cefdinir
CU23337B7 (es) Resolución de sal quiral
AR042273A1 (es) Derivados de pirazol, procedimiento para prepararlos y las composiciones farmaceuticas que los contienen
BRPI0410705A (pt) forma cristalina de agonista de receptor 2 adrenérgico
CY1113047T1 (el) Νεα κρυσταλλικη και αμορφη μορφη μιας ενωσης τριαζολο (4,5-d) πυριμιδινης
AR110019A2 (es) Forma cristalina de un compuesto de quinolinona-carboxamida
BR0313234A (pt) Composto, uso do mesmo, método de tratamento ou profilaxia de doenças, composição farmacêutica, e, processo para a preparação de um composto
NO20006221L (no) Fremgangsmåte for bekjempelse av skadedyr
ATE407926T1 (de) Krystallinform beta von ivabradine-hydrochlorid, verfahren zu dessen herstellung und diesen enthaltende pharamazeutische zusammensetzung
BR0213931A (pt) Forma polimórfica de rimonabant, processo para sua preparação e composições farmacêuticas contendo-as
BR9909739A (pt) Benzotiadiazóis e derivados
AR019365A1 (es) Compuesto de 1-piperidin-3-fenil-butil-naftamida, proceso para prepararlo, composicion farmaceutica y uso para fabricar un medicamento util para eltratamiento de una enfermedad por antagonistas de taquicininas neuropeptidicas endogenas
MXPA04008152A (es) Compuestos azabiciclicos para el tratamiento de enfermedades.
TNSN04024A1 (en) Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation
PE20050473A1 (es) Nuevos derivados de pirimidin-2-amina
DE69229339D1 (de) Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung
TWI319399B (en) Biguanide and dihydrotriazine derivatives
SI1656381T1 (sl) Kristalizacija trdnih oblik adicijskih soli klopidogrela
BR0316724A (pt) Compostos, uso de um ou mais compostos, e, processo para a fabricação de composições farmacêuticas
WO2003033462A3 (en) Systems and methods for the generation of crystalline polymorphs
EA200701687A1 (ru) Гидрохлорид аморфного лерканидипина
BR9803949A (pt) Cristais de maltitol de formas particulares, composições cristalinas contendo os mesmos e processo para fabriacação dos mesmos
WO2003080631A3 (en) Plasma carboxypeptidase b inhibitors
BR0307880A (pt) Método para purificar um composto de nióbio e/ou um composto de tântalo altamente puro
SG139548A1 (en) New benzothiazine and benzothiadiazine compounds, a process for their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FC Refusal