PE20020603A1 - Derivados de pirimidina como antagonista del receptor del neuropeptido y (npy) - Google Patents
Derivados de pirimidina como antagonista del receptor del neuropeptido y (npy)Info
- Publication number
- PE20020603A1 PE20020603A1 PE2001001110A PE2001001110A PE20020603A1 PE 20020603 A1 PE20020603 A1 PE 20020603A1 PE 2001001110 A PE2001001110 A PE 2001001110A PE 2001001110 A PE2001001110 A PE 2001001110A PE 20020603 A1 PE20020603 A1 PE 20020603A1
- Authority
- PE
- Peru
- Prior art keywords
- npy
- neuropeptide
- receptor
- pyrimidine
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00124610 | 2000-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020603A1 true PE20020603A1 (es) | 2002-07-20 |
Family
ID=8170342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001001110A PE20020603A1 (es) | 2000-11-10 | 2001-11-08 | Derivados de pirimidina como antagonista del receptor del neuropeptido y (npy) |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6657060B2 (enExample) |
| EP (1) | EP1335906B1 (enExample) |
| JP (1) | JP2004524279A (enExample) |
| KR (1) | KR100611853B1 (enExample) |
| CN (1) | CN1473156A (enExample) |
| AR (1) | AR034700A1 (enExample) |
| AT (1) | ATE340784T1 (enExample) |
| AU (2) | AU2790502A (enExample) |
| BR (1) | BR0115045A (enExample) |
| CA (1) | CA2427350A1 (enExample) |
| DE (1) | DE60123458T2 (enExample) |
| DK (1) | DK1335906T3 (enExample) |
| ES (1) | ES2271100T3 (enExample) |
| MX (1) | MXPA03004136A (enExample) |
| PA (1) | PA8531701A1 (enExample) |
| PE (1) | PE20020603A1 (enExample) |
| PT (1) | PT1335906E (enExample) |
| UY (1) | UY27018A1 (enExample) |
| WO (1) | WO2002038551A1 (enExample) |
| ZA (1) | ZA200302970B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3813152B2 (ja) | 2002-03-12 | 2006-08-23 | メルク エンド カムパニー インコーポレーテッド | 置換アミド類 |
| EP1484971B1 (en) * | 2002-03-15 | 2007-07-04 | Ciba SC Holding AG | Use of 4-aminopyrimidines for the antimicrobial treatment of surfaces |
| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| US7768604B2 (en) * | 2005-09-20 | 2010-08-03 | Au Optronics Corporation | Transflective liquid crystal display with partially shifted reflectivity curve |
| KR20080083188A (ko) * | 2006-01-11 | 2008-09-16 | 아스트라제네카 아베 | 모르폴리노 피리미딘 유도체 및 요법에서의 그 유도체의용도 |
| GB0616747D0 (en) * | 2006-08-24 | 2006-10-04 | Astrazeneca Ab | Novel compounds |
| EP2057129A1 (en) * | 2006-08-24 | 2009-05-13 | AstraZeneca AB | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| AU2007287428B2 (en) * | 2006-08-24 | 2011-08-11 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| CA2692720A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k |
| EP2178866A2 (en) * | 2007-07-09 | 2010-04-28 | AstraZeneca AB | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| EA201000092A1 (ru) * | 2007-07-09 | 2010-06-30 | Астразенека Аб | Тризамещенные пиримидиновые производные для лечения пролиферативных заболеваний |
| AU2008273892A1 (en) * | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| WO2010030027A1 (en) | 2008-09-10 | 2010-03-18 | Mitsubishi Tanabe Pharma Corporation | Aromatic nitrogen-containing 6-membered ring compounds and their use |
| US20110053923A1 (en) * | 2008-12-22 | 2011-03-03 | Astrazeneca | Chemical compounds 610 |
| JP2011201873A (ja) * | 2010-03-03 | 2011-10-13 | Mitsubishi Tanabe Pharma Corp | 三置換ピリミジン化合物及びそのｐｄｅ１０阻害薬としての使用 |
| EP2544690A4 (en) * | 2010-03-11 | 2013-07-10 | Targacept Inc | ARYLVINYLAZACYCLOALCANE COMPOUNDS FOR CONSTIPATION |
| SA111320519B1 (ar) | 2010-06-11 | 2014-07-02 | Astrazeneca Ab | مركبات بيريميدينيل للاستخدام كمثبطات atr |
| WO2015039292A1 (zh) * | 2013-09-18 | 2015-03-26 | 华安医学股份有限公司 | 一种活化ampk的化合物及其用途 |
| CN112375042A (zh) * | 2020-10-27 | 2021-02-19 | 安徽医科大学 | 三甲氧基苯乙烯基六元环类和吡唑并嘧啶类化合物、制剂及其制备与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0720467B2 (ja) * | 1988-06-15 | 1995-03-08 | 松下電器産業株式会社 | 超音波診断装置 |
| JPH024345A (ja) * | 1988-06-15 | 1990-01-09 | Matsushita Electric Ind Co Ltd | 超音波変換装置 |
| JP2789134B2 (ja) | 1992-09-28 | 1998-08-20 | ファイザー・インク． | 糖尿病の合併症を制御する置換ピリミジン類 |
| US6011039A (en) | 1996-03-21 | 2000-01-04 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives |
| WO1998040356A1 (en) * | 1997-03-12 | 1998-09-17 | Banyu Pharmaceutical Co., Ltd. | Drugs containing aminopyridine derivatives as the active ingredient |
-
2001
- 2001-11-06 WO PCT/EP2001/012818 patent/WO2002038551A1/en not_active Ceased
- 2001-11-06 ES ES01989438T patent/ES2271100T3/es not_active Expired - Lifetime
- 2001-11-06 CN CNA018186343A patent/CN1473156A/zh active Pending
- 2001-11-06 CA CA002427350A patent/CA2427350A1/en not_active Abandoned
- 2001-11-06 KR KR1020037006306A patent/KR100611853B1/ko not_active Expired - Fee Related
- 2001-11-06 EP EP01989438A patent/EP1335906B1/en not_active Expired - Lifetime
- 2001-11-06 BR BR0115045-6A patent/BR0115045A/pt not_active IP Right Cessation
- 2001-11-06 AU AU2790502A patent/AU2790502A/xx active Pending
- 2001-11-06 DE DE60123458T patent/DE60123458T2/de not_active Expired - Fee Related
- 2001-11-06 MX MXPA03004136A patent/MXPA03004136A/es active IP Right Grant
- 2001-11-06 PT PT01989438T patent/PT1335906E/pt unknown
- 2001-11-06 AT AT01989438T patent/ATE340784T1/de not_active IP Right Cessation
- 2001-11-06 AU AU2002227905A patent/AU2002227905B2/en not_active Ceased
- 2001-11-06 DK DK01989438T patent/DK1335906T3/da active
- 2001-11-06 JP JP2002541086A patent/JP2004524279A/ja active Pending
- 2001-11-07 PA PA20018531701A patent/PA8531701A1/es unknown
- 2001-11-08 AR ARP010105229A patent/AR034700A1/es unknown
- 2001-11-08 US US10/008,166 patent/US6657060B2/en not_active Expired - Fee Related
- 2001-11-08 PE PE2001001110A patent/PE20020603A1/es not_active Application Discontinuation
- 2001-11-09 UY UY27018A patent/UY27018A1/es not_active Application Discontinuation
-
2003
- 2003-04-15 ZA ZA200302970A patent/ZA200302970B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60123458T2 (de) | 2007-08-02 |
| DK1335906T3 (da) | 2007-02-05 |
| BR0115045A (pt) | 2004-02-03 |
| KR100611853B1 (ko) | 2006-08-11 |
| ATE340784T1 (de) | 2006-10-15 |
| WO2002038551A1 (en) | 2002-05-16 |
| DE60123458D1 (de) | 2006-11-09 |
| UY27018A1 (es) | 2002-06-20 |
| CA2427350A1 (en) | 2002-05-16 |
| PT1335906E (pt) | 2007-01-31 |
| US6657060B2 (en) | 2003-12-02 |
| JP2004524279A (ja) | 2004-08-12 |
| MXPA03004136A (es) | 2003-08-19 |
| US20020086858A1 (en) | 2002-07-04 |
| AR034700A1 (es) | 2004-03-17 |
| AU2790502A (en) | 2002-05-21 |
| AU2002227905B2 (en) | 2006-10-05 |
| EP1335906A1 (en) | 2003-08-20 |
| KR20040004432A (ko) | 2004-01-13 |
| CN1473156A (zh) | 2004-02-04 |
| ES2271100T3 (es) | 2007-04-16 |
| ZA200302970B (en) | 2004-07-15 |
| EP1335906B1 (en) | 2006-09-27 |
| PA8531701A1 (es) | 2003-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |