PA8531701A1 - Derivados de pirimidina - Google Patents
Derivados de pirimidinaInfo
- Publication number
- PA8531701A1 PA8531701A1 PA20018531701A PA8531701A PA8531701A1 PA 8531701 A1 PA8531701 A1 PA 8531701A1 PA 20018531701 A PA20018531701 A PA 20018531701A PA 8531701 A PA8531701 A PA 8531701A PA 8531701 A1 PA8531701 A1 PA 8531701A1
- Authority
- PA
- Panama
- Prior art keywords
- pirimidine derivatives
- pirimidine
- derivatives
- obesity
- arthritis
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00124610 | 2000-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8531701A1 true PA8531701A1 (es) | 2003-06-30 |
Family
ID=8170342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20018531701A PA8531701A1 (es) | 2000-11-10 | 2001-11-07 | Derivados de pirimidina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6657060B2 (enExample) |
| EP (1) | EP1335906B1 (enExample) |
| JP (1) | JP2004524279A (enExample) |
| KR (1) | KR100611853B1 (enExample) |
| CN (1) | CN1473156A (enExample) |
| AR (1) | AR034700A1 (enExample) |
| AT (1) | ATE340784T1 (enExample) |
| AU (2) | AU2002227905B2 (enExample) |
| BR (1) | BR0115045A (enExample) |
| CA (1) | CA2427350A1 (enExample) |
| DE (1) | DE60123458T2 (enExample) |
| DK (1) | DK1335906T3 (enExample) |
| ES (1) | ES2271100T3 (enExample) |
| MX (1) | MXPA03004136A (enExample) |
| PA (1) | PA8531701A1 (enExample) |
| PE (1) | PE20020603A1 (enExample) |
| PT (1) | PT1335906E (enExample) |
| UY (1) | UY27018A1 (enExample) |
| WO (1) | WO2002038551A1 (enExample) |
| ZA (1) | ZA200302970B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ534757A (en) | 2002-03-12 | 2006-07-28 | Merck & Co Inc | Substituted amides |
| CN1642422A (zh) * | 2002-03-15 | 2005-07-20 | 西巴特殊化学品控股有限公司 | 4－氨基嘧啶及其在表面抗菌处理中的应用 |
| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| US7768604B2 (en) * | 2005-09-20 | 2010-08-03 | Au Optronics Corporation | Transflective liquid crystal display with partially shifted reflectivity curve |
| GB0616747D0 (en) * | 2006-08-24 | 2006-10-04 | Astrazeneca Ab | Novel compounds |
| WO2007080382A1 (en) * | 2006-01-11 | 2007-07-19 | Astrazeneca Ab | Morpholino pyrimidine derivatives and their use in therapy |
| CA2660758A1 (en) | 2006-08-24 | 2008-02-27 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| JP2010501537A (ja) * | 2006-08-24 | 2010-01-21 | アストラゼネカ アクチボラグ | 増殖性障害の治療に有用なモルホリノピリミジン誘導体 |
| WO2009007749A2 (en) * | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| BRPI0814818A2 (pt) * | 2007-07-09 | 2019-09-10 | Astrazeneca Ab | composto, uso de um composto, métodos para produzir um efeito anti-proliferativo e um efeito inibitório de mtor quinase em uma animal de sangue quente, método para tratar doenças, e, composição farmacêutica |
| CA2692720A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k |
| CA2692725A1 (en) * | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Compound - 946 |
| US20110166135A1 (en) * | 2008-09-10 | 2011-07-07 | Hiroshi Morimoto | Aromatic nitrogen-containing 6-membered ring compounds and their use |
| TW201028410A (en) * | 2008-12-22 | 2010-08-01 | Astrazeneca Ab | Chemical compounds 610 |
| JP2011201873A (ja) * | 2010-03-03 | 2011-10-13 | Mitsubishi Tanabe Pharma Corp | 三置換ピリミジン化合物及びそのｐｄｅ１０阻害薬としての使用 |
| AU2011224697A1 (en) * | 2010-03-11 | 2012-10-04 | Targacept, Inc. | Arylvinylazacycloalkane compounds for constipation |
| SA111320519B1 (ar) | 2010-06-11 | 2014-07-02 | Astrazeneca Ab | مركبات بيريميدينيل للاستخدام كمثبطات atr |
| WO2015039292A1 (zh) * | 2013-09-18 | 2015-03-26 | 华安医学股份有限公司 | 一种活化ampk的化合物及其用途 |
| CN112375042A (zh) * | 2020-10-27 | 2021-02-19 | 安徽医科大学 | 三甲氧基苯乙烯基六元环类和吡唑并嘧啶类化合物、制剂及其制备与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH024345A (ja) * | 1988-06-15 | 1990-01-09 | Matsushita Electric Ind Co Ltd | 超音波変換装置 |
| JPH0720467B2 (ja) * | 1988-06-15 | 1995-03-08 | 松下電器産業株式会社 | 超音波診断装置 |
| WO1994007867A1 (en) | 1992-09-28 | 1994-04-14 | Pfizer Inc. | Substituted pyrimidines for control of diabetic complications |
| WO1997034873A1 (en) | 1996-03-21 | 1997-09-25 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives |
| WO1998040356A1 (en) * | 1997-03-12 | 1998-09-17 | Banyu Pharmaceutical Co., Ltd. | Drugs containing aminopyridine derivatives as the active ingredient |
-
2001
- 2001-11-06 AU AU2002227905A patent/AU2002227905B2/en not_active Ceased
- 2001-11-06 MX MXPA03004136A patent/MXPA03004136A/es active IP Right Grant
- 2001-11-06 PT PT01989438T patent/PT1335906E/pt unknown
- 2001-11-06 BR BR0115045-6A patent/BR0115045A/pt not_active IP Right Cessation
- 2001-11-06 DK DK01989438T patent/DK1335906T3/da active
- 2001-11-06 CN CNA018186343A patent/CN1473156A/zh active Pending
- 2001-11-06 WO PCT/EP2001/012818 patent/WO2002038551A1/en not_active Ceased
- 2001-11-06 JP JP2002541086A patent/JP2004524279A/ja active Pending
- 2001-11-06 DE DE60123458T patent/DE60123458T2/de not_active Expired - Fee Related
- 2001-11-06 KR KR1020037006306A patent/KR100611853B1/ko not_active Expired - Fee Related
- 2001-11-06 AT AT01989438T patent/ATE340784T1/de not_active IP Right Cessation
- 2001-11-06 CA CA002427350A patent/CA2427350A1/en not_active Abandoned
- 2001-11-06 ES ES01989438T patent/ES2271100T3/es not_active Expired - Lifetime
- 2001-11-06 EP EP01989438A patent/EP1335906B1/en not_active Expired - Lifetime
- 2001-11-06 AU AU2790502A patent/AU2790502A/xx active Pending
- 2001-11-07 PA PA20018531701A patent/PA8531701A1/es unknown
- 2001-11-08 US US10/008,166 patent/US6657060B2/en not_active Expired - Fee Related
- 2001-11-08 PE PE2001001110A patent/PE20020603A1/es not_active Application Discontinuation
- 2001-11-08 AR ARP010105229A patent/AR034700A1/es unknown
- 2001-11-09 UY UY27018A patent/UY27018A1/es not_active Application Discontinuation
-
2003
- 2003-04-15 ZA ZA200302970A patent/ZA200302970B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1335906A1 (en) | 2003-08-20 |
| ATE340784T1 (de) | 2006-10-15 |
| ZA200302970B (en) | 2004-07-15 |
| DE60123458T2 (de) | 2007-08-02 |
| PT1335906E (pt) | 2007-01-31 |
| UY27018A1 (es) | 2002-06-20 |
| ES2271100T3 (es) | 2007-04-16 |
| AU2002227905B2 (en) | 2006-10-05 |
| DK1335906T3 (da) | 2007-02-05 |
| KR100611853B1 (ko) | 2006-08-11 |
| MXPA03004136A (es) | 2003-08-19 |
| AR034700A1 (es) | 2004-03-17 |
| WO2002038551A1 (en) | 2002-05-16 |
| AU2790502A (en) | 2002-05-21 |
| JP2004524279A (ja) | 2004-08-12 |
| PE20020603A1 (es) | 2002-07-20 |
| US6657060B2 (en) | 2003-12-02 |
| CN1473156A (zh) | 2004-02-04 |
| EP1335906B1 (en) | 2006-09-27 |
| KR20040004432A (ko) | 2004-01-13 |
| US20020086858A1 (en) | 2002-07-04 |
| BR0115045A (pt) | 2004-02-03 |
| DE60123458D1 (de) | 2006-11-09 |
| CA2427350A1 (en) | 2002-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PA8528401A1 (es) | Derivados de quinolina y quinazolina | |
| UY27300A1 (es) | Nuevos derivados de quinolina | |
| PA8531701A1 (es) | Derivados de pirimidina | |
| PA8555401A1 (es) | Derivados de quinolina | |
| HN2002000275A (es) | Derivados de 1,8 naftiridina y su uso para el tratamiento de diabetes y trastornos relacionados | |
| UY27646A1 (es) | Derivados de quinolina como antagonistas de npt | |
| CR9667A (es) | Derivados de benzamida y usos relacionados con los mismos | |
| ECSP077401A (es) | Medicamentos que contienen compuestos de carbonilo y su uso | |
| UY27097A1 (es) | Derivados del indol | |
| PA8534801A1 (es) | Derivados de piperazina | |
| CO5570667A2 (es) | Compuestos azabiciclico sustituidos condensados con heteroarilo para el tratamiento de enfermedades | |
| CY1111206T1 (el) | Βενζοθειοφαινια υποκατεστημενα με πιπεραζινη για την αγωγη διανοητικων διαταραχων | |
| UY28376A1 (es) | Agentes terapéuticos | |
| ECSP045004A (es) | Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades andrógeno dependientes | |
| ECSP067043A (es) | Derivados de pirrolotriazina útiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogénesis | |
| SV2002000478A (es) | Derivados de tiofeno utiles como anticancerosos ref. pc10795aagl/bb | |
| UY28098A1 (es) | Derivados de anilinopirazol útiles en el tratamiento de la diabetes | |
| DOP2009000165A (es) | Derivados de oxindol sustituido, medicamentos que los comprenden y uso de los mismos | |
| IS8485A (is) | Notkun á setnum 2-amínótetralínum í fyrirbyggjandi meðferð á Parkinsons-veiki | |
| BRPI0508051A (pt) | derivados de heteroarilaminopirazol utilizáveis para o tratamento de diabetes | |
| UY28377A1 (es) | Agentes terapeuticos | |
| CO5611124A2 (es) | Derivados de benzofurano substituidos utiles en el tratamiento de desordenes hiper-proliferativos | |
| PA8540801A1 (es) | Derivados de piperacina | |
| BRPI0512705A (pt) | composto, processo de preparação deste e método para o tratamento e profilaxia de diabetes, obesidade, distúrbios alimentares, dilipidemia, hipertensão e diabetes do tipo ii | |
| ECSP088250A (es) | Derivados de pirazol como agentes terapéuticos |