PE20020542A1 - Sulfoxibenzamidas como antagonistas de leucotrieno b4 - Google Patents
Sulfoxibenzamidas como antagonistas de leucotrieno b4Info
- Publication number
- PE20020542A1 PE20020542A1 PE2001001045A PE2001001045A PE20020542A1 PE 20020542 A1 PE20020542 A1 PE 20020542A1 PE 2001001045 A PE2001001045 A PE 2001001045A PE 2001001045 A PE2001001045 A PE 2001001045A PE 20020542 A1 PE20020542 A1 PE 20020542A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxy
- phenyl
- antagonists
- haloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
- C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A SULFOXIBENZAMIDAS DE FORMULA I; Zo ES X1(CH2)rX2, CR4R5; R4 Y R5 SON H, ALQUILO C1-C4; A1 Y A2 SON 1,4 FENILENO, 1,3-FENILENO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO C1-C8, ALQUENILO C2-C8, HALOALQUILO C1-C8, ALCOXI C1-C8; Z1 Y Z2 SON X3(CH2)sX4, ENLACE; m Y n SON 0-1; R1 ES H, OH, COO-ALQUILO C1-C8, COO-ALQUIL C1-C4, FENILO OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C4, ALCOXI C1-C4; X1, X2, X3, X4 SON O, S, N, UN ENLACE; R2 Y R3 SON H, HALOGENO, ALQUILO C1-C8, HALOALQUILO C1-C8, ALCOXI C1-C8, ARILO, ARILOXI, ARALQUILO. SON COMPUESTOS PREFERIDOS 4-[[3-[[4-[1-METIL-1-[4-(SULFOXI)FENIL]ETIL]FENOXI]METIL]FENIL]METOXI-BENCENOCARBOXIMIDAMIDA; 3'-PROPIL-4'-[2-[3-(SULFOXI)FENOXI]ETOXI][1,1'-BIFENIL]-4-CARBOXIMIDAMIDA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON ANTAGONISTAS DE LEUCOTRIENO B4 LTB4 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ARTRITIS, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA PSORIASIS, COLITIS ULCEROSA, GASTROPATIA, ENTEROPATIA INDUCIDA POR ANTIFLOGISTICOS NO ESTEROIDES, FIBROSIS QUISTICA O PULMONAR, ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10052333A DE10052333A1 (de) | 2000-10-24 | 2000-10-24 | Neue Sulfooxybenzamide |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020542A1 true PE20020542A1 (es) | 2002-07-16 |
Family
ID=7660637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001001045A PE20020542A1 (es) | 2000-10-24 | 2001-10-22 | Sulfoxibenzamidas como antagonistas de leucotrieno b4 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1332128A1 (es) |
JP (1) | JP3917516B2 (es) |
AU (1) | AU2002210558A1 (es) |
CA (1) | CA2425368C (es) |
DE (1) | DE10052333A1 (es) |
MX (1) | MXPA03003465A (es) |
PE (1) | PE20020542A1 (es) |
WO (1) | WO2002034715A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1997491B1 (en) * | 2004-07-14 | 2010-09-22 | Inflammation Research Center Company Ltd. | Method for inhibiting tumor metastasis |
DE602005019897D1 (de) * | 2005-07-08 | 2010-04-22 | Leopold Franzens Uni Innsbruck | Verwendung von Extrakten und Inhaltsstoffen aus Leontopodium zur Steigerung der cholinergen Funktion |
CN100402494C (zh) * | 2005-08-25 | 2008-07-16 | 江苏吴中苏药医药开发有限责任公司 | 肌醇硫酸酯铝及其制备方法和口服组合物、应用 |
EA024381B1 (ru) | 2011-03-16 | 2016-09-30 | Криэйтив Терапьютикс Гмбх | Замещенные дифенильные производные |
JP7373191B2 (ja) | 2017-05-12 | 2023-11-02 | 国立研究開発法人理化学研究所 | クラスa gpcr結合性化合物改変体 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2165122T3 (es) * | 1992-02-05 | 2002-03-01 | Boehringer Ingelheim Pharma | Nuevos derivados de amidina, su preparacion y utilizacion como medicamentos con efecto antagonista de ltb4. |
DE19546452A1 (de) * | 1995-12-13 | 1997-06-19 | Boehringer Ingelheim Kg | Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel |
DE19636689A1 (de) * | 1996-09-10 | 1998-03-12 | Boehringer Ingelheim Kg | Neue Benzamidinderivate |
-
2000
- 2000-10-24 DE DE10052333A patent/DE10052333A1/de not_active Withdrawn
-
2001
- 2001-10-19 CA CA002425368A patent/CA2425368C/en not_active Expired - Fee Related
- 2001-10-19 MX MXPA03003465A patent/MXPA03003465A/es unknown
- 2001-10-19 AU AU2002210558A patent/AU2002210558A1/en not_active Abandoned
- 2001-10-19 EP EP01978439A patent/EP1332128A1/de not_active Withdrawn
- 2001-10-19 WO PCT/EP2001/012127 patent/WO2002034715A1/de active Application Filing
- 2001-10-19 JP JP2002537708A patent/JP3917516B2/ja not_active Expired - Fee Related
- 2001-10-22 PE PE2001001045A patent/PE20020542A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2004512322A (ja) | 2004-04-22 |
DE10052333A1 (de) | 2002-05-02 |
AU2002210558A1 (en) | 2002-05-06 |
MXPA03003465A (es) | 2004-12-06 |
CA2425368A1 (en) | 2003-04-08 |
CA2425368C (en) | 2008-12-09 |
JP3917516B2 (ja) | 2007-05-23 |
WO2002034715A1 (de) | 2002-05-02 |
EP1332128A1 (de) | 2003-08-06 |
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