PE20010398A1 - Procedimiento para preparar acidos a traves de alfa-cloroepoxi-esteres - Google Patents
Procedimiento para preparar acidos a traves de alfa-cloroepoxi-esteresInfo
- Publication number
- PE20010398A1 PE20010398A1 PE2000000790A PE0007902000A PE20010398A1 PE 20010398 A1 PE20010398 A1 PE 20010398A1 PE 2000000790 A PE2000000790 A PE 2000000790A PE 0007902000 A PE0007902000 A PE 0007902000A PE 20010398 A1 PE20010398 A1 PE 20010398A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cr4r5
- procedure
- acids
- chloroepoxi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE REFIERE A PROCEDIMIENTOS PARA LA PREPARACION DE ACIDOS CICLOHEXANOICOS SUSTITUIDOS DE FORMULA I, DONDE: Ra ES UN GRUPO LIGADO POR O, S o N AL CICLOHEXILO; j ES 1-10; R Y R* SON H, C(O)E; E ES OR14, SR14; R14 ES H, ALQUILO C1-C6; QUE COMPRENDE TRATAR UN EPOXIDO A CON DIMETILSULFOXIDO; Y ES Br, Cl, F, I. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS IA; R1 ES (CR4R5)nCOO(CR4R5)mR6, ENTRE OTROS; m ES 0-2; n ES 0-4; r ES 0-6; R4 Y R5 SON H, ALQUILO C1-C2; R6 ES H, CH3, OH, ENTRE OTROS; CUANDO R6 ES OH; m ES 2 o r ES 2-6; CUANDO R6 ES TETRAHIDROPIRANILO, 2-TETRAHIDROTIOPIRANILO, ENTRE OTROS; X ES YR2; Y, X2 SON O; R2 ES CH3, CH2CH3; W ES UN ENLACE, ALQUILENO C2-C6, ALQUINILO C2-C6; CUANDO W ES UN ENLACE, R` ES H, HALOGENO, ALQUILO C1-C4, CH2NHCOCONH2, CN, OR5, ENTRE OTROS; R7 ES (CR4R5)qR12, ALQUILO C1-C6; q ES 0-2; R12 ES R13, CICLOALQUILO C3-C7, ARILO, ENTRE OTROS; R8 ES H, R9; R9 ES ALQUILO C1-C4; R10 ES OR8 O R11; R11 ES H, ALQUILO C1-C4 QUE COMPRENDE TRATAR UN EPOXIDO DE FORMULA A CON DIMETILSULFOXIDO Y UNA SAL DE METAL ALCALINO LiCl, KCl; LA REACCION SE LLEVA A CABO ENTRE 125°C-175°C, DURANTE 2-5 h. UN COMPUESTO IA PREFERIDO ES ACIDO 4-CIANO-4-(3-CICLOPENTILOXI)-4-METOXIFENIL)CICLOHEXANO-1-CARBOXILICO. LOS ACIDOS SON UTILES COMO INHIBIDORES DE LA FOSFODIESTERASA 4 Y PUEDE SER UTIL PARA TRATAR EPOC
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14757699P | 1999-08-06 | 1999-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010398A1 true PE20010398A1 (es) | 2001-06-14 |
Family
ID=22522121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000790A PE20010398A1 (es) | 1999-08-06 | 2000-08-04 | Procedimiento para preparar acidos a traves de alfa-cloroepoxi-esteres |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1200394B1 (es) |
| JP (1) | JP2003506431A (es) |
| KR (1) | KR20020022793A (es) |
| CN (4) | CN1530362A (es) |
| AR (1) | AR025028A1 (es) |
| AT (1) | ATE340780T1 (es) |
| AU (1) | AU774582B2 (es) |
| BR (1) | BR0013025A (es) |
| CA (1) | CA2381010A1 (es) |
| CO (1) | CO5190744A1 (es) |
| CZ (1) | CZ2002428A3 (es) |
| DE (1) | DE60030981T2 (es) |
| EC (1) | ECSP003599A (es) |
| ES (1) | ES2272310T3 (es) |
| HK (1) | HK1047080A1 (es) |
| HU (1) | HUP0202453A2 (es) |
| IL (1) | IL147365A0 (es) |
| MX (1) | MXPA02001337A (es) |
| NO (1) | NO20020561L (es) |
| NZ (1) | NZ516945A (es) |
| PE (1) | PE20010398A1 (es) |
| PL (1) | PL353347A1 (es) |
| TR (1) | TR200200307T2 (es) |
| UY (1) | UY26268A1 (es) |
| WO (1) | WO2001010822A1 (es) |
| ZA (1) | ZA200200965B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101116828B (zh) * | 2006-08-03 | 2011-06-01 | 中国科学院大连化学物理研究所 | 手性吡啶双噁唑啉催化剂及制备方法和应用 |
| WO2016172496A1 (en) | 2015-04-23 | 2016-10-27 | Constellation Pharmaceuticals, Inc. | Lsd1 inhibitors and uses thereof |
| HRP20231369T1 (hr) | 2016-10-26 | 2024-02-16 | Constellation Pharmaceuticals, Inc. | Inhibitori lsd1 i njihova medicinska upotreba |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3803593A (en) * | 1992-04-02 | 1993-11-08 | Smithkline Beecham Corporation | Compounds |
| NZ251092A (en) * | 1992-04-02 | 1996-12-20 | Smithkline Beecham Corp | 4-cyano-cyclohexane derivatives; medicaments; used in treating asthma |
| JP3195352B2 (ja) * | 1992-04-02 | 2001-08-06 | スミスクライン・ビーチャム・コーポレイション | アレルギーおよび炎症疾患の治療用化合物 |
| AU3924993A (en) * | 1992-04-02 | 1993-11-08 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
| GB9404706D0 (en) * | 1994-03-11 | 1994-04-27 | Smithkline Beecham Corp | Compounds |
| AR012550A1 (es) * | 1997-02-12 | 2000-11-08 | Smithkline Beecham Corp | Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios |
-
2000
- 2000-08-02 UY UY26268A patent/UY26268A1/es not_active Application Discontinuation
- 2000-08-02 EC EC2000003599A patent/ECSP003599A/es unknown
- 2000-08-03 CO CO00058243A patent/CO5190744A1/es not_active Application Discontinuation
- 2000-08-03 AR ARP000104011A patent/AR025028A1/es not_active Application Discontinuation
- 2000-08-04 IL IL14736500A patent/IL147365A0/xx unknown
- 2000-08-04 CN CNA2004100321634A patent/CN1530362A/zh active Pending
- 2000-08-04 KR KR1020027001574A patent/KR20020022793A/ko active IP Right Grant
- 2000-08-04 NZ NZ516945A patent/NZ516945A/en unknown
- 2000-08-04 CN CNA2004100321649A patent/CN1597675A/zh active Pending
- 2000-08-04 AU AU66222/00A patent/AU774582B2/en not_active Ceased
- 2000-08-04 HU HU0202453A patent/HUP0202453A2/hu unknown
- 2000-08-04 CN CN008113440A patent/CN1217923C/zh not_active Expired - Fee Related
- 2000-08-04 BR BR0013025-7A patent/BR0013025A/pt not_active IP Right Cessation
- 2000-08-04 ES ES00953844T patent/ES2272310T3/es not_active Expired - Lifetime
- 2000-08-04 AT AT00953844T patent/ATE340780T1/de not_active IP Right Cessation
- 2000-08-04 EP EP00953844A patent/EP1200394B1/en not_active Expired - Lifetime
- 2000-08-04 PE PE2000000790A patent/PE20010398A1/es not_active Application Discontinuation
- 2000-08-04 CA CA002381010A patent/CA2381010A1/en not_active Abandoned
- 2000-08-04 PL PL00353347A patent/PL353347A1/xx not_active Application Discontinuation
- 2000-08-04 DE DE60030981T patent/DE60030981T2/de not_active Expired - Lifetime
- 2000-08-04 WO PCT/US2000/021394 patent/WO2001010822A1/en active IP Right Grant
- 2000-08-04 JP JP2001515289A patent/JP2003506431A/ja not_active Withdrawn
- 2000-08-04 TR TR2002/00307T patent/TR200200307T2/xx unknown
- 2000-08-04 CN CNB2004100321653A patent/CN1266119C/zh not_active Expired - Fee Related
- 2000-08-04 CZ CZ2002428A patent/CZ2002428A3/cs unknown
- 2000-08-04 MX MXPA02001337A patent/MXPA02001337A/es unknown
-
2002
- 2002-02-04 ZA ZA200200965A patent/ZA200200965B/en unknown
- 2002-02-05 NO NO20020561A patent/NO20020561L/no not_active Application Discontinuation
- 2002-09-27 HK HK02107178.7A patent/HK1047080A1/zh unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |