KR910004623A - 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성염 및 그 제조방법. - Google Patents
4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성염 및 그 제조방법. Download PDFInfo
- Publication number
- KR910004623A KR910004623A KR1019900013033A KR900013033A KR910004623A KR 910004623 A KR910004623 A KR 910004623A KR 1019900013033 A KR1019900013033 A KR 1019900013033A KR 900013033 A KR900013033 A KR 900013033A KR 910004623 A KR910004623 A KR 910004623A
- Authority
- KR
- South Korea
- Prior art keywords
- lower alkoxy
- pyrazolo
- hydroxy
- optically active
- phenylsulfinylphenyl
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 일반식(식중, R은 저급 알콕시기이다)로 표시되는 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성체의 알칼리금속염 및 알칼리 토금속염으로 이루어진군으로 부터 선택된 것을 특징으로 하는 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성염.
- 일반식(식중, R은 저급 알콕시기이다)로 표시되는 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학활성체 또는, 일반식(식중, R1는 저급알킬기, 페닐기 또는 페닐저급알킬기이다)로 표시되는 광학활성 고리형 화합물의 존재하에 할로겐 함유 산화제와 일반식(식중, R은 저급 알콕시기이다) 로 표시되는 4-히드록시-8-(3-저급알콕시-4-페닐티오페닐)피라졸로[1,5-a]-1,3,5-트리아진을 반응시키고, 그 반응생성물을 물 또는 금속 수산화물과 반응시키거나 열처리하며, 필요에 따라 생성물을 알칼리금속 수산화물이거나 알칼리토금속 수산화물과 반응시켜 얻은 염으로 된 상기 광학활성체 화합물의 알칼리금속염 또는 알칼리토금속염의 제조방법.
- 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진 화합물의 광학활성체 또는, 트리아진과 같은 광학활성체 단독으로 이루어진 조결정으로, 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 타센미 혼합용액을 숙성하여 광학 활성체에 상용하는 결정화를 야기하며, 생성된 결정을 분리하고, 필요에 따라 생성물을 알칼리금속 수산화물이나 알칼리토금속 수산화물로 처리하여 얻은 염으로 된 광학활성체 화합물의 알칼리 금속염 및 알칼리 토금속 염으로 이루어진 군으로 부터 선택된 염의 제조방법.
- 제1항 기재 염의 유효량과 의학적 허용 무독성 담체로 이루어지고 크산틴 옥시다아제 억제활성을 갖는 의약 조성물.
- 제4항에 있어서, 향통풍약제인 의약조성물.
- 제4항 또는 제5항에 있어서, 주사액 형태로 된 의약조성물.
- 제1항기재 염의 유효량을 환자에게 투여하여 환자의 통풍을 치료하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP219181/1889 | 1989-08-25 | ||
JP21918189 | 1989-08-25 | ||
JP219181/1989 | 1989-08-25 | ||
JP2179852A JP2691317B2 (ja) | 1989-08-25 | 1990-07-06 | 4―ヒドロキシ―8―(3―低級アルコキシ―4―フェニルスルフィニルフェニル)ピラゾロ〔1,5―a〕―1,3,5―トリアジン光学活性体の塩類及びその製造方法 |
JP179852/1990 | 1990-07-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910004623A true KR910004623A (ko) | 1991-03-29 |
KR960002851B1 KR960002851B1 (ko) | 1996-02-27 |
Family
ID=26499580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900013033A KR960002851B1 (ko) | 1989-08-25 | 1990-08-23 | 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성염 및 그 제조방법 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5137887A (ko) |
EP (1) | EP0414200B1 (ko) |
JP (1) | JP2691317B2 (ko) |
KR (1) | KR960002851B1 (ko) |
CN (1) | CN1028528C (ko) |
AU (1) | AU630489B2 (ko) |
CA (1) | CA2023430C (ko) |
DE (1) | DE69021296T2 (ko) |
DK (1) | DK0414200T3 (ko) |
ES (1) | ES2075860T3 (ko) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5420128A (en) * | 1990-10-09 | 1995-05-30 | Otsuka Pharmaceutical Co., Ltd. | Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor |
DE69307999T2 (de) * | 1992-11-27 | 1997-08-14 | Sumitomo Spec Metals | Herstellungsverfahren für einen auf Seltenerd-Eisen-Stickstoff basierter Dauermagnet |
US6124289A (en) | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
NZ333777A (en) * | 1996-07-24 | 2000-07-28 | Du Pont Pharm Co | (1,5-a) pyrazolo and triazole triazines and pyrimidines |
US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
AU4331500A (en) * | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolotriazines as crf antagonists |
WO2000059908A2 (en) | 1999-04-06 | 2000-10-12 | Du Pont Pharmaceuticals Company | Pyrazolopyrimidines as crf antagonists |
DK1206474T3 (da) * | 1999-08-27 | 2004-10-04 | Abbott Lab | Sulfonylphenylpyrazolforbindelser anvendelige som cox-2-inhibitorer |
US6630476B2 (en) | 2000-07-07 | 2003-10-07 | Bristol-Myers Squibb Pharma Company | Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists |
US7329658B2 (en) * | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
US7153961B2 (en) * | 2003-11-25 | 2006-12-26 | Bristol-Myers Squibb Pharma Co. | Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist |
US7208596B2 (en) * | 2003-11-25 | 2007-04-24 | Bristol-Myers Squibb Pharma Company | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof |
WO2005121153A1 (ja) * | 2004-06-14 | 2005-12-22 | Nippon Chemiphar Co., Ltd. | 縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤 |
JPWO2007004688A1 (ja) * | 2005-07-01 | 2009-01-29 | 日本ケミファ株式会社 | キサンチンオキシダーゼ阻害剤 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4824834A (en) * | 1986-10-31 | 1989-04-25 | Otsuka Pharmaceutical Company, Limited | Pyrazolotriazine compounds |
-
1990
- 1990-07-06 JP JP2179852A patent/JP2691317B2/ja not_active Expired - Fee Related
- 1990-08-15 US US07/567,632 patent/US5137887A/en not_active Expired - Fee Related
- 1990-08-15 AU AU60985/90A patent/AU630489B2/en not_active Ceased
- 1990-08-16 CA CA002023430A patent/CA2023430C/en not_active Expired - Fee Related
- 1990-08-21 ES ES90115961T patent/ES2075860T3/es not_active Expired - Lifetime
- 1990-08-21 DK DK90115961.6T patent/DK0414200T3/da active
- 1990-08-21 EP EP90115961A patent/EP0414200B1/en not_active Expired - Lifetime
- 1990-08-21 DE DE69021296T patent/DE69021296T2/de not_active Expired - Fee Related
- 1990-08-23 KR KR1019900013033A patent/KR960002851B1/ko not_active IP Right Cessation
- 1990-08-24 CN CN90107308A patent/CN1028528C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1049664A (zh) | 1991-03-06 |
DE69021296D1 (de) | 1995-09-07 |
JP2691317B2 (ja) | 1997-12-17 |
ES2075860T3 (es) | 1995-10-16 |
EP0414200B1 (en) | 1995-08-02 |
CA2023430C (en) | 1997-11-11 |
EP0414200A3 (en) | 1991-11-13 |
AU6098590A (en) | 1991-02-28 |
US5137887A (en) | 1992-08-11 |
JPH03163082A (ja) | 1991-07-15 |
KR960002851B1 (ko) | 1996-02-27 |
CA2023430A1 (en) | 1991-02-26 |
DK0414200T3 (da) | 1995-12-27 |
DE69021296T2 (de) | 1996-02-01 |
CN1028528C (zh) | 1995-05-24 |
EP0414200A2 (en) | 1991-02-27 |
AU630489B2 (en) | 1992-10-29 |
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