KR910004623A - 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성염 및 그 제조방법. - Google Patents

4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성염 및 그 제조방법. Download PDF

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KR910004623A
KR910004623A KR1019900013033A KR900013033A KR910004623A KR 910004623 A KR910004623 A KR 910004623A KR 1019900013033 A KR1019900013033 A KR 1019900013033A KR 900013033 A KR900013033 A KR 900013033A KR 910004623 A KR910004623 A KR 910004623A
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South Korea
Prior art keywords
lower alkoxy
pyrazolo
hydroxy
optically active
phenylsulfinylphenyl
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KR1019900013033A
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KR960002851B1 (ko
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긴지 하시도또
마사또시 이나이
Original Assignee
오스카 아끼히꼬
가부시끼기이샤 오스카 세이야꾸 고오조
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성염 및 그 제조방법.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식
    (식중, R은 저급 알콕시기이다)로 표시되는 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성체의 알칼리금속염 및 알칼리 토금속염으로 이루어진군으로 부터 선택된 것을 특징으로 하는 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성염.
  2. 일반식
    (식중, R은 저급 알콕시기이다)로 표시되는 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학활성체 또는, 일반식
    (식중, R1는 저급알킬기, 페닐기 또는 페닐저급알킬기이다)로 표시되는 광학활성 고리형 화합물의 존재하에 할로겐 함유 산화제와 일반식
    (식중, R은 저급 알콕시기이다) 로 표시되는 4-히드록시-8-(3-저급알콕시-4-페닐티오페닐)피라졸로[1,5-a]-1,3,5-트리아진을 반응시키고, 그 반응생성물을 물 또는 금속 수산화물과 반응시키거나 열처리하며, 필요에 따라 생성물을 알칼리금속 수산화물이거나 알칼리토금속 수산화물과 반응시켜 얻은 염으로 된 상기 광학활성체 화합물의 알칼리금속염 또는 알칼리토금속염의 제조방법.
  3. 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진 화합물의 광학활성체 또는, 트리아진과 같은 광학활성체 단독으로 이루어진 조결정으로, 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 타센미 혼합용액을 숙성하여 광학 활성체에 상용하는 결정화를 야기하며, 생성된 결정을 분리하고, 필요에 따라 생성물을 알칼리금속 수산화물이나 알칼리토금속 수산화물로 처리하여 얻은 염으로 된 광학활성체 화합물의 알칼리 금속염 및 알칼리 토금속 염으로 이루어진 군으로 부터 선택된 염의 제조방법.
  4. 제1항 기재 염의 유효량과 의학적 허용 무독성 담체로 이루어지고 크산틴 옥시다아제 억제활성을 갖는 의약 조성물.
  5. 제4항에 있어서, 향통풍약제인 의약조성물.
  6. 제4항 또는 제5항에 있어서, 주사액 형태로 된 의약조성물.
  7. 제1항기재 염의 유효량을 환자에게 투여하여 환자의 통풍을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900013033A 1989-08-25 1990-08-23 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성염 및 그 제조방법 KR960002851B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP219181/1889 1989-08-25
JP21918189 1989-08-25
JP219181/1989 1989-08-25
JP2179852A JP2691317B2 (ja) 1989-08-25 1990-07-06 ４―ヒドロキシ―８―（３―低級アルコキシ―４―フェニルスルフィニルフェニル）ピラゾロ〔１，５―ａ〕―１，３，５―トリアジン光学活性体の塩類及びその製造方法
JP179852/1990 1990-07-06

Publications (2)

Publication Number Publication Date
KR910004623A true KR910004623A (ko) 1991-03-29
KR960002851B1 KR960002851B1 (ko) 1996-02-27

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KR1019900013033A KR960002851B1 (ko) 1989-08-25 1990-08-23 4-히드록시-8-(3-저급알콕시-4-페닐술피닐페닐)피라졸로[1,5-a]-1,3,5-트리아진의 광학 활성염 및 그 제조방법

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US (1) US5137887A (ko)
EP (1) EP0414200B1 (ko)
JP (1) JP2691317B2 (ko)
KR (1) KR960002851B1 (ko)
CN (1) CN1028528C (ko)
AU (1) AU630489B2 (ko)
CA (1) CA2023430C (ko)
DE (1) DE69021296T2 (ko)
DK (1) DK0414200T3 (ko)
ES (1) ES2075860T3 (ko)

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Publication number Priority date Publication date Assignee Title
US5420128A (en) * 1990-10-09 1995-05-30 Otsuka Pharmaceutical Co., Ltd. Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor
DE69307999T2 (de) * 1992-11-27 1997-08-14 Sumitomo Spec Metals Herstellungsverfahren für einen auf Seltenerd-Eisen-Stickstoff basierter Dauermagnet
US6124289A (en) 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
NZ333777A (en) * 1996-07-24 2000-07-28 Du Pont Pharm Co (1,5-a) pyrazolo and triazole triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
AU4331500A (en) * 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
DK1206474T3 (da) * 1999-08-27 2004-10-04 Abbott Lab Sulfonylphenylpyrazolforbindelser anvendelige som cox-2-inhibitorer
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7153961B2 (en) * 2003-11-25 2006-12-26 Bristol-Myers Squibb Pharma Co. Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist
US7208596B2 (en) * 2003-11-25 2007-04-24 Bristol-Myers Squibb Pharma Company Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
WO2005121153A1 (ja) * 2004-06-14 2005-12-22 Nippon Chemiphar Co., Ltd. 縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤
JPWO2007004688A1 (ja) * 2005-07-01 2009-01-29 日本ケミファ株式会社 キサンチンオキシダーゼ阻害剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824834A (en) * 1986-10-31 1989-04-25 Otsuka Pharmaceutical Company, Limited Pyrazolotriazine compounds

Also Published As

Publication number Publication date
CN1049664A (zh) 1991-03-06
DE69021296D1 (de) 1995-09-07
JP2691317B2 (ja) 1997-12-17
ES2075860T3 (es) 1995-10-16
EP0414200B1 (en) 1995-08-02
CA2023430C (en) 1997-11-11
EP0414200A3 (en) 1991-11-13
AU6098590A (en) 1991-02-28
US5137887A (en) 1992-08-11
JPH03163082A (ja) 1991-07-15
KR960002851B1 (ko) 1996-02-27
CA2023430A1 (en) 1991-02-26
DK0414200T3 (da) 1995-12-27
DE69021296T2 (de) 1996-02-01
CN1028528C (zh) 1995-05-24
EP0414200A2 (en) 1991-02-27
AU630489B2 (en) 1992-10-29

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