DE60030981D1 - Ein verfahren zur herstellung von säuren via alpha-chloroepoxy-esther - Google Patents

Ein verfahren zur herstellung von säuren via alpha-chloroepoxy-esther

Info

Publication number
DE60030981D1
DE60030981D1 DE60030981T DE60030981T DE60030981D1 DE 60030981 D1 DE60030981 D1 DE 60030981D1 DE 60030981 T DE60030981 T DE 60030981T DE 60030981 T DE60030981 T DE 60030981T DE 60030981 D1 DE60030981 D1 DE 60030981D1
Authority
DE
Germany
Prior art keywords
chloroepoxy
esther
preparation
acids via
via alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60030981T
Other languages
English (en)
Other versions
DE60030981T2 (de
Inventor
M Diederich
J Novak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of DE60030981D1 publication Critical patent/DE60030981D1/de
Application granted granted Critical
Publication of DE60030981T2 publication Critical patent/DE60030981T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60030981T 1999-08-06 2000-08-04 Verfahren zur herstellung von säuren via alpha-chloroepoxy-ester Expired - Lifetime DE60030981T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14757699P 1999-08-06 1999-08-06
US147576P 1999-08-06
PCT/US2000/021394 WO2001010822A1 (en) 1999-08-06 2000-08-04 Process for preparing acids via alpha-chloroepoxy esters

Publications (2)

Publication Number Publication Date
DE60030981D1 true DE60030981D1 (de) 2006-11-09
DE60030981T2 DE60030981T2 (de) 2007-09-06

Family

ID=22522121

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60030981T Expired - Lifetime DE60030981T2 (de) 1999-08-06 2000-08-04 Verfahren zur herstellung von säuren via alpha-chloroepoxy-ester

Country Status (26)

Country Link
EP (1) EP1200394B1 (de)
JP (1) JP2003506431A (de)
KR (1) KR20020022793A (de)
CN (4) CN1530362A (de)
AR (1) AR025028A1 (de)
AT (1) ATE340780T1 (de)
AU (1) AU774582B2 (de)
BR (1) BR0013025A (de)
CA (1) CA2381010A1 (de)
CO (1) CO5190744A1 (de)
CZ (1) CZ2002428A3 (de)
DE (1) DE60030981T2 (de)
EC (1) ECSP003599A (de)
ES (1) ES2272310T3 (de)
HK (1) HK1047080A1 (de)
HU (1) HUP0202453A2 (de)
IL (1) IL147365A0 (de)
MX (1) MXPA02001337A (de)
NO (1) NO20020561D0 (de)
NZ (1) NZ516945A (de)
PE (1) PE20010398A1 (de)
PL (1) PL353347A1 (de)
TR (1) TR200200307T2 (de)
UY (1) UY26268A1 (de)
WO (1) WO2001010822A1 (de)
ZA (1) ZA200200965B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101116828B (zh) * 2006-08-03 2011-06-01 中国科学院大连化学物理研究所 手性吡啶双噁唑啉催化剂及制备方法和应用
WO2016172496A1 (en) 2015-04-23 2016-10-27 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and uses thereof
FI3532459T3 (fi) 2016-10-26 2023-10-23 Constellation Pharmaceuticals Inc Lsd1-estäjiä ja niiden lääkinnällisiä käyttöjä

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3803593A (en) * 1992-04-02 1993-11-08 Smithkline Beecham Corporation Compounds
US5605923A (en) * 1992-04-02 1997-02-25 Smithkline Beecham Corporation Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor
AU677776B2 (en) * 1992-04-02 1997-05-08 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
AU3738293A (en) * 1992-04-02 1993-11-08 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
GB9404706D0 (en) * 1994-03-11 1994-04-27 Smithkline Beecham Corp Compounds
UY24882A1 (es) * 1997-02-12 2001-08-27 Smithkline Beecham Corp Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos

Also Published As

Publication number Publication date
CN1266119C (zh) 2006-07-26
PL353347A1 (en) 2003-11-17
IL147365A0 (en) 2002-08-14
CZ2002428A3 (cs) 2002-06-12
CN1217923C (zh) 2005-09-07
ES2272310T3 (es) 2007-05-01
MXPA02001337A (es) 2002-07-22
CN1530362A (zh) 2004-09-22
NO20020561L (no) 2002-02-05
AU774582B2 (en) 2004-07-01
BR0013025A (pt) 2002-04-16
KR20020022793A (ko) 2002-03-27
EP1200394A4 (de) 2004-12-01
AU6622200A (en) 2001-03-05
CN1597675A (zh) 2005-03-23
EP1200394A1 (de) 2002-05-02
EP1200394B1 (de) 2006-09-27
AR025028A1 (es) 2002-11-06
ECSP003599A (es) 2002-03-25
CO5190744A1 (es) 2002-08-29
NZ516945A (en) 2004-01-30
JP2003506431A (ja) 2003-02-18
CA2381010A1 (en) 2001-02-15
HUP0202453A2 (en) 2002-10-28
WO2001010822A1 (en) 2001-02-15
NO20020561D0 (no) 2002-02-05
UY26268A1 (es) 2001-01-31
TR200200307T2 (tr) 2002-05-21
HK1047080A1 (zh) 2003-02-07
ATE340780T1 (de) 2006-10-15
PE20010398A1 (es) 2001-06-14
ZA200200965B (en) 2003-04-30
CN1368955A (zh) 2002-09-11
CN1530360A (zh) 2004-09-22
DE60030981T2 (de) 2007-09-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition