DE60114098D1 - Ein verfahren zur herstellung von trifluorothymidin-derivaten - Google Patents

Ein verfahren zur herstellung von trifluorothymidin-derivaten

Info

Publication number
DE60114098D1
DE60114098D1 DE60114098T DE60114098T DE60114098D1 DE 60114098 D1 DE60114098 D1 DE 60114098D1 DE 60114098 T DE60114098 T DE 60114098T DE 60114098 T DE60114098 T DE 60114098T DE 60114098 D1 DE60114098 D1 DE 60114098D1
Authority
DE
Germany
Prior art keywords
preparation
trifluorothymidine
derivatives
trifluorothymidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60114098T
Other languages
English (en)
Other versions
DE60114098T2 (de
Inventor
Hideki Umetani
Nobuyuki Fukazawa
Hironori Komatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Application granted granted Critical
Publication of DE60114098D1 publication Critical patent/DE60114098D1/de
Publication of DE60114098T2 publication Critical patent/DE60114098T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60114098T 2000-02-10 2001-02-09 Ein Verfahren zur Herstellung von Trifluorothymidinderivaten Expired - Fee Related DE60114098T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000033202 2000-02-10
JP2000033202 2000-02-10
PCT/JP2001/000945 WO2001058917A1 (fr) 2000-02-10 2001-02-09 Procede de preparation de derives de trifluorothymidine

Publications (2)

Publication Number Publication Date
DE60114098D1 true DE60114098D1 (de) 2005-11-24
DE60114098T2 DE60114098T2 (de) 2006-05-18

Family

ID=18557714

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60114098T Expired - Fee Related DE60114098T2 (de) 2000-02-10 2001-02-09 Ein Verfahren zur Herstellung von Trifluorothymidinderivaten

Country Status (8)

Country Link
US (1) US6423852B1 (de)
EP (1) EP1176150B1 (de)
JP (1) JP2001294596A (de)
KR (1) KR100441387B1 (de)
CN (1) CN1191265C (de)
CA (1) CA2354888A1 (de)
DE (1) DE60114098T2 (de)
WO (1) WO2001058917A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004084453A2 (en) * 2003-03-20 2004-09-30 Microbiologica Quimica E Farmaceutica Ltd. METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES
CN101576749B (zh) * 2009-06-09 2011-03-30 武汉理工大学 一种在线质量校准系统
CN105461772B (zh) * 2015-11-23 2018-01-12 国药一心制药有限公司 一种曲氟尿苷中间体及曲氟尿苷的制备方法
CN110007010A (zh) * 2018-01-05 2019-07-12 大鹏药品工业株式会社 源自曲氟尿苷的类似物质的检测方法
AU2019310704B2 (en) 2018-07-24 2022-05-19 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Method for preparing trifluridine
KR200490643Y1 (ko) 2019-07-03 2019-12-10 이계훈 셔츠소매 흘러내림 방지장치
KR102078648B1 (ko) 2019-12-02 2020-02-19 이계훈 셔츠소매 흘러내림 방지장치
CN112979721B (zh) * 2021-03-29 2023-05-09 江苏集萃分子工程研究院有限公司 一种高纯度抗肿瘤药曲氟胞苷的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02289595A (ja) * 1989-02-22 1990-11-29 Yuki Gosei Kogyo Co Ltd ２’―デオキシ―５―トリフルオロメチル―β―ウリジンの製造方法
US5532349A (en) * 1993-07-20 1996-07-02 Mitsui Toatsu Chemicals, Inc. Process for producing 1-(2'-deoxy-β-D-erythro-pentofuranosyl)-5-trifluoromethyluracil derivatives
US5459243A (en) * 1994-03-10 1995-10-17 Isis Pharmaceuticals, Inc. Apparatus and processes for the large scale generation and transfer of diazomethane

Also Published As

Publication number Publication date
DE60114098T2 (de) 2006-05-18
WO2001058917A1 (fr) 2001-08-16
CN1191265C (zh) 2005-03-02
EP1176150B1 (de) 2005-10-19
EP1176150A4 (de) 2003-04-23
CN1366530A (zh) 2002-08-28
EP1176150A1 (de) 2002-01-30
KR20020013520A (ko) 2002-02-20
US6423852B1 (en) 2002-07-23
JP2001294596A (ja) 2001-10-23
CA2354888A1 (en) 2001-08-10
KR100441387B1 (ko) 2004-07-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee