PE20010157A1 - Composiciones farmaceuticas que contienen inhibidores de oxido nitrico sintasa, inhibidores selectivos de la recaptacion de la serotonina, antagonistas del receptor nk-1 - Google Patents

Composiciones farmaceuticas que contienen inhibidores de oxido nitrico sintasa, inhibidores selectivos de la recaptacion de la serotonina, antagonistas del receptor nk-1

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Publication number
PE20010157A1
PE20010157A1 PE2000000473A PE0004732000A PE20010157A1 PE 20010157 A1 PE20010157 A1 PE 20010157A1 PE 2000000473 A PE2000000473 A PE 2000000473A PE 0004732000 A PE0004732000 A PE 0004732000A PE 20010157 A1 PE20010157 A1 PE 20010157A1
Authority
PE
Peru
Prior art keywords
recaptation
serotonin
inhibitors
nitric oxide
oxide synthase
Prior art date
Application number
PE2000000473A
Other languages
English (en)
Inventor
Iii John Adams Lowe
Mario David Saltarelli
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20010157A1 publication Critical patent/PE20010157A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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Abstract

SE REFIERE A UNA COMPOSICION QUE COMPRENDE: a)UN COMPUESTO INHIBIDOR DE LA OXIDO NITRICO SINTASA (NOS) TAL COMO 6-[4-(3-AMINO-CICLOHEXILOXI)-NAFTALEN-1-IL]-PIRIDIN-2-ILAMINA, 6-[4-(3-AMINO-CICLOPENTILOXI)-NAFTALEN-1-IL]-PIRIDIN-2-ILAMINA, ENTRE OTROS; b)UN ANTAGONISTA DEL RECEPTOR NK-1 TAL COMO 2-(DIFENILMETIL)-N-((2-DIFLUOROMETOXI)FENIL)METIL-1-AZABICICLO[2.2.2]OCTAN-3-AMINA, (2S,3S)-N-(2-METOXI-5-TRIFLUOROMETOXIFENIL)METIL-2-DIFENILMETIL-1-AZABICICLO[2.2.2]OCTANO-3-AMINA, (2S,3S)-2-FENIL-3-[2-(2,2,2-TRIFLUOROETOXI)BENCIL]AMINOPIPERIDINA, ENTRE OTROS; c) UN INHIBIDOR SELECTIVO DE LA RECAPTACION DE SEROTONINA (SSRI) TAL COMO SERTRALINA, FLUOXETINA, FLUVOXAMINA, CITALOPRAN, PAROXETINA. LA COMPOSICION FARMACEUTICA ALTERACION DE LOS RITMOS CIRCADIANOS Y PUEDE SER UTIL PARA EL TRATAMIENTO DE CEGUERA, OBESIDAD, TRASTORNO AFECTIVO ESTACIONAL, TRASTORNO BIPOLAR, PRIVACION DEL SUENO, TRASTORNOS DEL SUENO REM
PE2000000473A 1999-05-21 2000-05-19 Composiciones farmaceuticas que contienen inhibidores de oxido nitrico sintasa, inhibidores selectivos de la recaptacion de la serotonina, antagonistas del receptor nk-1 PE20010157A1 (es)

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DE10001785A1 (de) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms
GB0019006D0 (en) * 2000-08-04 2000-09-20 Astrazeneca Ab Novel compounds
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US6803470B2 (en) * 2001-10-10 2004-10-12 Pfizer Inc 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
DOP2002000467A (es) * 2001-10-10 2003-04-15 Pfizer Prod Inc 2-amino-6 (fenilo sustituido en las posiciones 2,4,5)-piridinas
JP2009513491A (ja) 2003-06-24 2009-04-02 ノイロサーチ アクティーゼルスカブ 新規な８−アザ−ビシクロ［３．２．１］オクタン誘導体、及びモノアミン神経伝達物質の再取り込み阻害剤としてのその使用
EP1634598A1 (en) * 2004-09-07 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
CA2687918C (en) 2007-06-08 2016-11-08 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
US8835437B2 (en) 2007-06-08 2014-09-16 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
CL2008001671A1 (es) 2007-06-08 2009-07-17 Janssen Pharmaceutica Nv Compuestos derivados de piperidina/piperazina inhibidores de dgat1, composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades metabolicas especialmente diabetes.
EP2296659B1 (en) 2008-06-05 2016-12-21 Janssen Pharmaceutica, N.V. Drug combinations comprising a DGAT inhibitor and a PPAR-agonist
JP5642661B2 (ja) * 2009-03-05 2014-12-17 塩野義製薬株式会社 Ｎｐｙｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
AU2020291468A1 (en) * 2019-06-14 2022-01-06 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)

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BR0010820A (pt) 2002-03-05
NO20015651D0 (no) 2001-11-20
CA2374668A1 (en) 2000-11-30
KR20020010916A (ko) 2002-02-06
TR200103351T2 (tr) 2002-06-21
GT200000071A (es) 2001-11-08
MXPA01011978A (es) 2002-05-06
HN2000000045A (es) 2001-03-02
WO2000071107A2 (en) 2000-11-30
HUP0301287A2 (hu) 2003-08-28
OA11943A (en) 2006-04-12
EP1178784A1 (en) 2002-02-13
BG106208A (en) 2002-09-30
NO20015651L (no) 2002-01-18
PL358538A1 (en) 2004-08-09
EA200101110A1 (ru) 2002-08-29
CO5160295A1 (es) 2002-05-30
TNSN00106A1 (fr) 2005-11-10
PA8494601A1 (es) 2002-08-29
HRP20010862A2 (en) 2003-06-30
AR022640A1 (es) 2002-09-04
IL145955A0 (en) 2002-07-25
UY26148A1 (es) 2000-12-29
MA26732A1 (fr) 2004-12-20
DZ3041A1 (fr) 2004-03-27
IS6126A (is) 2001-10-26
CN1617743A (zh) 2005-05-18
SK16602001A3 (sk) 2003-03-04
JP2003523941A (ja) 2003-08-12
ZA200109555B (en) 2004-04-07
HUP0301287A3 (en) 2005-03-29
EE200100611A (et) 2003-02-17
AU2935300A (en) 2000-12-12
WO2000071107A8 (en) 2002-01-24
AP2001002326A0 (en) 2001-12-31

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