PA8494601A1 - Nuevas combinaciones farmaceuticas para inhibidores de la nos - Google Patents

Nuevas combinaciones farmaceuticas para inhibidores de la nos

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Publication number
PA8494601A1
PA8494601A1 PA20008494601A PA8494601A PA8494601A1 PA 8494601 A1 PA8494601 A1 PA 8494601A1 PA 20008494601 A PA20008494601 A PA 20008494601A PA 8494601 A PA8494601 A PA 8494601A PA 8494601 A1 PA8494601 A1 PA 8494601A1
Authority
PA
Panama
Prior art keywords
disorders
inhibitors
sound
nos
new pharmaceutical
Prior art date
Application number
PA20008494601A
Other languages
English (en)
Inventor
Mario David Saltarelli
Iii John Adams Lowe
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8494601A1 publication Critical patent/PA8494601A1/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS USOS FARMACEUTICOS PARA COMPUESTOS QUE PRESENTAN ACTIVIDAD COMO INHIBIDORES DE LA OXIDO NITRICO SINTASA (NOS). ESPECIFICAMENTE, SE REFIERE AL USO DE INHIBIDORES DE LA NOS, PARTICULARMENTE DE INHIBIDORES SELECTIVOS DE LA NOS NEURONAL (NNOS), SOLOS O EN COMBINACION CON OTRO AGENTE ACTIVO, EN PARTICULAR, UN SSRI O UN ANTAGONISTA DEL RECEPTOR NK-1, PARA EL TRATAMIENTO DE TRASTORNOS O AFECCIONES CUYO TRATAMIENTO PUEDE REALIZARSE O FACILITARSE MEDIANTE LA ALTERACION DE LOS RITMOS CIRCADIANOS. SON EJEMPLOS DE TALES TRASTORNOS Y AFECCIONES LA CEGUERA, LA OBESIDAD EL TRASTORNO AFECTIVO ESTACIONAL, EL TRASTORNO BIPOLAR, EL DESFACE HORARIO, TRASTORNOS DE LOS RITMOS CIRCADIANOS DEL SUENO, PRIVACION DE SUENO, PARASOMNIAS, TRASTORNOS DEL SUENO REM, HIPERSOMNIA, TRASTORNOS DE LOS CICLOS DE SUENO-VIGILIA, NARCOLEPSIA Y TRASTORNOS DEL SUENO ASOCIADO CON EL TRABAJO A TURNOS O CON HORARIOS DE TRABAJO IRREGULAR; ENURESIS NOCTURNA Y SINDROME DE LAS PIERNAS INQUIETAS.
PA20008494601A 1999-05-21 2000-04-25 Nuevas combinaciones farmaceuticas para inhibidores de la nos PA8494601A1 (es)

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DE10001785A1 (de) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms
GB0019006D0 (en) * 2000-08-04 2000-09-20 Astrazeneca Ab Novel compounds
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US6803470B2 (en) * 2001-10-10 2004-10-12 Pfizer Inc 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
DOP2002000467A (es) * 2001-10-10 2003-04-15 Pfizer Prod Inc 2-amino-6 (fenilo sustituido en las posiciones 2,4,5)-piridinas
BRPI0411608A (pt) 2003-06-24 2006-08-08 Neurosearch As derivado de 8-aza-biciclo [3.2.1] octano, composição farmacêutica, uso do composto, e, método de tratamento, prevenção ou alìvio de uma doença, um distúrbio ou uma condição de um organismo animal vivo
EP1634598A1 (en) * 2004-09-07 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
US8981094B2 (en) 2007-06-08 2015-03-17 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
US8835437B2 (en) 2007-06-08 2014-09-16 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
EP2152269B1 (en) 2007-06-08 2014-04-23 Janssen Pharmaceutica, N.V. Piperidine/piperazine derivatives
PE20140572A1 (es) 2008-06-05 2014-05-16 Janssen Pharmaceutica Nv Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
EP2404902A1 (en) * 2009-03-05 2012-01-11 Shionogi&Co., Ltd. Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2020252383A2 (en) * 2019-06-14 2020-12-17 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9)

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BR0010820A (pt) 2002-03-05
MA26732A1 (fr) 2004-12-20
CA2374668A1 (en) 2000-11-30
AU2935300A (en) 2000-12-12
NO20015651D0 (no) 2001-11-20
AR022640A1 (es) 2002-09-04
BG106208A (en) 2002-09-30
SK16602001A3 (sk) 2003-03-04
EA200101110A1 (ru) 2002-08-29
DZ3041A1 (fr) 2004-03-27
NO20015651L (no) 2002-01-18
OA11943A (en) 2006-04-12
GT200000071A (es) 2001-11-08
HUP0301287A2 (hu) 2003-08-28
UY26148A1 (es) 2000-12-29
CN1617743A (zh) 2005-05-18
MXPA01011978A (es) 2002-05-06
HRP20010862A2 (en) 2003-06-30
TNSN00106A1 (fr) 2005-11-10
IL145955A0 (en) 2002-07-25
CO5160295A1 (es) 2002-05-30
JP2003523941A (ja) 2003-08-12
IS6126A (is) 2001-10-26
KR20020010916A (ko) 2002-02-06
PL358538A1 (en) 2004-08-09
PE20010157A1 (es) 2001-02-16
HUP0301287A3 (en) 2005-03-29
AP2001002326A0 (en) 2001-12-31
EE200100611A (et) 2003-02-17
HN2000000045A (es) 2001-03-02
EP1178784A1 (en) 2002-02-13
ZA200109555B (en) 2004-04-07
WO2000071107A2 (en) 2000-11-30
WO2000071107A8 (en) 2002-01-24
TR200103351T2 (tr) 2002-06-21

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