AR022640A1 - Nuevas combinaciones farmaceuticas para inhibidores de la nos - Google Patents

Nuevas combinaciones farmaceuticas para inhibidores de la nos

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Publication number
AR022640A1
AR022640A1 ARP000102387A ARP000102387A AR022640A1 AR 022640 A1 AR022640 A1 AR 022640A1 AR P000102387 A ARP000102387 A AR P000102387A AR P000102387 A ARP000102387 A AR P000102387A AR 022640 A1 AR022640 A1 AR 022640A1
Authority
AR
Argentina
Prior art keywords
disorders
nos
inhibitors
sleep
new pharmaceutical
Prior art date
Application number
ARP000102387A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR022640A1 publication Critical patent/AR022640A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invencion se refiere a nuevos usos farmacéuticos para compuestos que presentan actividad como inhibidores del oxido nítrico sintasa (NOS).Específicamente, se refiere al uso de inhibidores de la NOS, particularmente de inhibidores selectivos de la NOS neuronal (nNOS), solos o en combinacion conotro agente activo, en particular un SSRI o un antagonista del receptor NK-1, para el tratamiento de trastornos o afecciones cuyo tratamiento puede realizarseo facilitarse mediante la alteracionde los ritmos circadianos. Son ejemplos de tales trastornos y afecciones la ceguera, la obesidad, el trastorno afectivoestacional, el trastorno bipolar, el desfase horario, trastornos de los ritmos circadianos del sueno, privacion de sueno, parasomnias, trastornos del suenoREM, hipersomnia, trastornos de los ciclos de sueno asociados con el trabajo a turnos o con horarios de trabajo irregulares; enuresis nocturna y síndrome delas piernas inquietas.
ARP000102387A 1999-05-21 2000-05-19 Nuevas combinaciones farmaceuticas para inhibidores de la nos AR022640A1 (es)

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DE10001785A1 (de) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms
GB0019006D0 (en) * 2000-08-04 2000-09-20 Astrazeneca Ab Novel compounds
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US6803470B2 (en) * 2001-10-10 2004-10-12 Pfizer Inc 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
DOP2002000467A (es) * 2001-10-10 2003-04-15 Pfizer Prod Inc 2-amino-6 (fenilo sustituido en las posiciones 2,4,5)-piridinas
CN100368409C (zh) 2003-06-24 2008-02-13 神经研究公司 8-氮杂双环[3.2.1]辛烷衍生物及其用于制备单胺神经递质再摄取抑制剂的用途
EP1634598A1 (en) * 2004-09-07 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
JP5443342B2 (ja) 2007-06-08 2014-03-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペリジン／ピペラジン誘導体
WO2008148851A1 (en) 2007-06-08 2008-12-11 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
PE20090362A1 (es) 2007-06-08 2009-04-04 Janssen Pharmaceutica Nv Derivados de piperidina/piperazina como moduladores de dgat
WO2009147170A2 (en) 2008-06-05 2009-12-10 Janssen Pharmaceutica Nv Drug combinations comprising a dgat inhibitor and a ppar-agonist
JP5642661B2 (ja) * 2009-03-05 2014-12-17 塩野義製薬株式会社 Ｎｐｙｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
JP2022537140A (ja) * 2019-06-14 2022-08-24 エスアールエックス カーディオ，エル エル シー プロタンパク質転換酵素サブチリシン／ケキシン９型（ｐｃｓｋ９）の調節のための化合物

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EE200100611A (et) 2003-02-17
AP2001002326A0 (en) 2001-12-31
BG106208A (en) 2002-09-30
PA8494601A1 (es) 2002-08-29
MA26732A1 (fr) 2004-12-20
AU2935300A (en) 2000-12-12
HN2000000045A (es) 2001-03-02
CN1617743A (zh) 2005-05-18
WO2000071107A2 (en) 2000-11-30
PL358538A1 (en) 2004-08-09
EP1178784A1 (en) 2002-02-13
NO20015651D0 (no) 2001-11-20
SK16602001A3 (sk) 2003-03-04
PE20010157A1 (es) 2001-02-16
HRP20010862A2 (en) 2003-06-30
TNSN00106A1 (fr) 2005-11-10
KR20020010916A (ko) 2002-02-06
OA11943A (en) 2006-04-12
JP2003523941A (ja) 2003-08-12
WO2000071107A8 (en) 2002-01-24
DZ3041A1 (fr) 2004-03-27
UY26148A1 (es) 2000-12-29
MXPA01011978A (es) 2002-05-06
IS6126A (is) 2001-10-26
GT200000071A (es) 2001-11-08
CO5160295A1 (es) 2002-05-30
HUP0301287A2 (hu) 2003-08-28
ZA200109555B (en) 2004-04-07
NO20015651L (no) 2002-01-18
HUP0301287A3 (en) 2005-03-29
BR0010820A (pt) 2002-03-05
EA200101110A1 (ru) 2002-08-29
TR200103351T2 (tr) 2002-06-21
IL145955A0 (en) 2002-07-25
CA2374668A1 (en) 2000-11-30

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