AR022640A1 - NEW PHARMACEUTICAL COMBINATIONS FOR NOS INHIBITORS - Google Patents

NEW PHARMACEUTICAL COMBINATIONS FOR NOS INHIBITORS

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Publication number
AR022640A1
AR022640A1 ARP000102387A ARP000102387A AR022640A1 AR 022640 A1 AR022640 A1 AR 022640A1 AR P000102387 A ARP000102387 A AR P000102387A AR P000102387 A ARP000102387 A AR P000102387A AR 022640 A1 AR022640 A1 AR 022640A1
Authority
AR
Argentina
Prior art keywords
disorders
nos
inhibitors
sleep
new pharmaceutical
Prior art date
Application number
ARP000102387A
Other languages
Spanish (es)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR022640A1 publication Critical patent/AR022640A1/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61P3/04—Anorexiants; Antiobesity agents

Abstract

La presente invencion se refiere a nuevos usos farmacéuticos para compuestos que presentan actividad como inhibidores del oxido nítrico sintasa (NOS).Específicamente, se refiere al uso de inhibidores de la NOS, particularmente de inhibidores selectivos de la NOS neuronal (nNOS), solos o en combinacion conotro agente activo, en particular un SSRI o un antagonista del receptor NK-1, para el tratamiento de trastornos o afecciones cuyo tratamiento puede realizarseo facilitarse mediante la alteracionde los ritmos circadianos. Son ejemplos de tales trastornos y afecciones la ceguera, la obesidad, el trastorno afectivoestacional, el trastorno bipolar, el desfase horario, trastornos de los ritmos circadianos del sueno, privacion de sueno, parasomnias, trastornos del suenoREM, hipersomnia, trastornos de los ciclos de sueno asociados con el trabajo a turnos o con horarios de trabajo irregulares; enuresis nocturna y síndrome delas piernas inquietas.The present invention relates to new pharmaceutical uses for compounds that exhibit activity as nitric oxide synthase (NOS) inhibitors. Specifically, it refers to the use of NOS inhibitors, particularly selective inhibitors of neuronal NOS (nNOS), alone or in combination with another active agent, in particular an SSRI or an NK-1 receptor antagonist, for the treatment of disorders or conditions whose treatment can be performed or facilitated by altering circadian rhythms. Examples of such disorders and conditions are blindness, obesity, seasonal affective disorder, bipolar disorder, time lag, circadian sleep rhythm disorders, sleep deprivation, parasomnias, sleep disorders REM, hypersomnia, cycle disorders I dream associated with shift work or irregular work schedules; nocturnal enuresis and restless legs syndrome.

ARP000102387A 1999-05-21 2000-05-19 NEW PHARMACEUTICAL COMBINATIONS FOR NOS INHIBITORS AR022640A1 (en)

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GB0019006D0 (en) * 2000-08-04 2000-09-20 Astrazeneca Ab Novel compounds
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US6803470B2 (en) * 2001-10-10 2004-10-12 Pfizer Inc 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
UA82517C2 (en) * 2003-06-24 2008-04-25 Ньюросерч А/С Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP1634598A1 (en) * 2004-09-07 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
JP5464709B2 (en) 2007-06-08 2014-04-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Piperidine / piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine/Piperazine derivatives
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EP2296659B1 (en) 2008-06-05 2016-12-21 Janssen Pharmaceutica, N.V. Drug combinations comprising a DGAT inhibitor and a PPAR-agonist
WO2010101246A1 (en) * 2009-03-05 2010-09-10 塩野義製薬株式会社 Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN114206843A (en) * 2019-06-14 2022-03-18 Srx心脏有限责任公司 Compounds for modulating proprotein convertase subtilisin/Kexin type 9(PCSK9)

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WO2000071107A2 (en) 2000-11-30
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PE20010157A1 (en) 2001-02-16
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AP2001002326A0 (en) 2001-12-31
JP2003523941A (en) 2003-08-12
GT200000071A (en) 2001-11-08
PA8494601A1 (en) 2002-08-29
MA26732A1 (en) 2004-12-20
TNSN00106A1 (en) 2005-11-10
EA200101110A1 (en) 2002-08-29
NO20015651L (en) 2002-01-18
HUP0301287A3 (en) 2005-03-29
TR200103351T2 (en) 2002-06-21
ZA200109555B (en) 2004-04-07
OA11943A (en) 2006-04-12
BG106208A (en) 2002-09-30
CA2374668A1 (en) 2000-11-30
SK16602001A3 (en) 2003-03-04
HUP0301287A2 (en) 2003-08-28
CN1617743A (en) 2005-05-18
AU2935300A (en) 2000-12-12
KR20020010916A (en) 2002-02-06
HRP20010862A2 (en) 2003-06-30
EP1178784A1 (en) 2002-02-13
MXPA01011978A (en) 2002-05-06
WO2000071107A8 (en) 2002-01-24
IL145955A0 (en) 2002-07-25
HN2000000045A (en) 2001-03-02
IS6126A (en) 2001-10-26
CO5160295A1 (en) 2002-05-30
UY26148A1 (en) 2000-12-29

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