UY26148A1 - NEW PHARMACEUTICAL COMBINATIONS FOR NOS INHIBITORS - Google Patents

NEW PHARMACEUTICAL COMBINATIONS FOR NOS INHIBITORS

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Publication number
UY26148A1
UY26148A1 UY26148A UY26148A UY26148A1 UY 26148 A1 UY26148 A1 UY 26148A1 UY 26148 A UY26148 A UY 26148A UY 26148 A UY26148 A UY 26148A UY 26148 A1 UY26148 A1 UY 26148A1
Authority
UY
Uruguay
Prior art keywords
disorders
nos
sleep
inhibitors
sleep disorders
Prior art date
Application number
UY26148A
Other languages
Spanish (es)
Inventor
Mario David Saltarelli Joh Iii
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY26148A1 publication Critical patent/UY26148A1/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a nuevos usos farmacéuticos para compuestos que presentan actividad como inhibidores de la óxido nítrico sintasa (NOS). Específicamente, se refiere al uso de inhibidores de la NOS particularmente de inhibidores selectivos de la Nos neuronal (nNos), solos o en combinación con otro agente activo, en particular, un SSRI o un antagonista del receptor NK-1, para el tratamiento de trastornos o afecciones cuyo tratamiento puede realizarse o facilitarse mediante la alteración de los ritmos circadianos. Son ejemplos de tales trastornos y afecciones la ceguera, la obesidad, el trastorno afectivo estacional, el trastorno bipolar, el desfase horario, trastornos de los ritmos circadianos del sueno, privación de sueno, parasomnias, trastornos del sueno REM, hipersomnia, trastornos de los ciclos de sueno-vigilia, narcolepsia y trastornos del sueno asociados con el trabajo a turnos o con horarios de trabajo irregulares; enuresis nocturna y síndrome de las piernas inquietas.The present invention relates to novel pharmaceutical uses for compounds exhibiting activity as nitric oxide synthase (NOS) inhibitors. Specifically, it refers to the use of NOS inhibitors, particularly selective inhibitors of neuronal Nos (nNos), alone or in combination with another active agent, in particular, an SSRI or an NK-1 receptor antagonist, for the treatment of disorders or conditions whose treatment can be performed or facilitated by altering circadian rhythms. Examples of such disorders and conditions are blindness, obesity, seasonal affective disorder, bipolar disorder, jet lag, circadian rhythm sleep disorders, sleep deprivation, parasomnias, REM sleep disorders, hypersomnia, sleep-wake cycles, narcolepsy, and sleep disorders associated with shift work or irregular work schedules; nocturnal enuresis and restless legs syndrome.

UY26148A 1999-05-21 2000-05-18 NEW PHARMACEUTICAL COMBINATIONS FOR NOS INHIBITORS UY26148A1 (en)

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DE10001785A1 (en) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma Use of NK-1 receptor antagonists for treatment of restless legs syndrome
GB0019006D0 (en) * 2000-08-04 2000-09-20 Astrazeneca Ab Novel compounds
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US6803470B2 (en) * 2001-10-10 2004-10-12 Pfizer Inc 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
DOP2002000467A (en) * 2001-10-10 2003-04-15 Pfizer Prod Inc 2-AMINO-6 (PHENYL REPLACED IN POSITIONS 2,4,5) -PIRIDINES
CN100368409C (en) * 2003-06-24 2008-02-13 神经研究公司 Novel 8-aza-bicyclo not 3.2.1|octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP1634598A1 (en) * 2004-09-07 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
EP2152271B1 (en) 2007-06-08 2015-10-21 Janssen Pharmaceutica, N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine/Piperazine derivatives
WO2008148851A1 (en) 2007-06-08 2008-12-11 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
CN101678019B (en) 2007-06-08 2016-03-30 詹森药业有限公司 Piperidine/piperazine derivatives
WO2009147170A2 (en) 2008-06-05 2009-12-10 Janssen Pharmaceutica Nv Drug combinations comprising a dgat inhibitor and a ppar-agonist
WO2010101246A1 (en) 2009-03-05 2010-09-10 塩野義製薬株式会社 Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP3983392A4 (en) * 2019-06-14 2023-12-06 SRX Cardio, LLC Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9)

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CA2374668A1 (en) 2000-11-30
ZA200109555B (en) 2004-04-07
IS6126A (en) 2001-10-26
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AR022640A1 (en) 2002-09-04
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HUP0301287A2 (en) 2003-08-28
WO2000071107A2 (en) 2000-11-30
IL145955A0 (en) 2002-07-25
KR20020010916A (en) 2002-02-06
MA26732A1 (en) 2004-12-20
NO20015651L (en) 2002-01-18
EE200100611A (en) 2003-02-17
PE20010157A1 (en) 2001-02-16
TR200103351T2 (en) 2002-06-21
GT200000071A (en) 2001-11-08
CN1617743A (en) 2005-05-18
PL358538A1 (en) 2004-08-09
HRP20010862A2 (en) 2003-06-30
MXPA01011978A (en) 2002-05-06
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PA8494601A1 (en) 2002-08-29
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