CO5160295A1 - NEW PHARMACEUTICAL COMBINATIONS FOR INHIBITORS OF THE US A SSRI - Google Patents

NEW PHARMACEUTICAL COMBINATIONS FOR INHIBITORS OF THE US A SSRI

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Publication number
CO5160295A1
CO5160295A1 CO00024427A CO00024427A CO5160295A1 CO 5160295 A1 CO5160295 A1 CO 5160295A1 CO 00024427 A CO00024427 A CO 00024427A CO 00024427 A CO00024427 A CO 00024427A CO 5160295 A1 CO5160295 A1 CO 5160295A1
Authority
CO
Colombia
Prior art keywords
ssri
inhibitors
pharmaceutically acceptable
acceptable salt
pharmaceutical combinations
Prior art date
Application number
CO00024427A
Other languages
Spanish (es)
Inventor
Mario David Saltarelli
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CO5160295A1 publication Critical patent/CO5160295A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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  • Neurology (AREA)
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  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Una composición farmacéutica para el tratamiento de un trastorno o afección que puede tratarse mediante la alteración de los ritmos circadianos en un mamífero, que comprende:(a) un compuesto inhibidor de la NOS o una sal farmacéuticamente aceptable del mismo;(b) opcionalmente un antagonista del receptor NK-1 o una sal farmacéuticamente aceptable del mismo; y(c) opcionalmente un SSRI o una sal farmacéuticamente aceptable del mismo;en la que los agentes "a", "b" y "c" están presentes en tal composición en cantidades que hacen a la combinación de los agentes presentes eficaz para tratar un trastorno o afección que puede tratarse mediante la alteración de los ritmos circadianos.A pharmaceutical composition for the treatment of a disorder or condition that can be treated by altering circadian rhythms in a mammal, comprising: (a) a NOS inhibitor compound or a pharmaceutically acceptable salt thereof; (b) optionally a NK-1 receptor antagonist or a pharmaceutically acceptable salt thereof; and (c) optionally an SSRI or a pharmaceutically acceptable salt thereof, in which agents "a", "b" and "c" are present in such composition in amounts that make the combination of the agents present effective for treating a disorder or condition that can be treated by altering circadian rhythms.

CO00024427A 1999-05-21 2000-04-04 NEW PHARMACEUTICAL COMBINATIONS FOR INHIBITORS OF THE US A SSRI CO5160295A1 (en)

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DE10001785A1 (en) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma Use of NK-1 receptor antagonists for treatment of restless legs syndrome
GB0019006D0 (en) * 2000-08-04 2000-09-20 Astrazeneca Ab Novel compounds
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US6803470B2 (en) * 2001-10-10 2004-10-12 Pfizer Inc 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
DOP2002000467A (en) * 2001-10-10 2003-04-15 Pfizer Prod Inc 2-AMINO-6 (PHENYL REPLACED IN POSITIONS 2,4,5) -PIRIDINES
BRPI0411608A (en) 2003-06-24 2006-08-08 Neurosearch As 8-aza-bicyclo [3.2.1] octane derivative, pharmaceutical composition, use of the compound, and method of treating, preventing or alleviating a disease, disorder or condition of a living animal organism
EP1634598A1 (en) * 2004-09-07 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
BRPI0813331A2 (en) 2007-06-08 2014-12-23 Janssen Pharmaceutica Nv PIPERIDINE / PIPERAZINE Derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine/Piperazine derivatives
ES2558152T3 (en) 2007-06-08 2016-02-02 Janssen Pharmaceutica, N.V. Piperidine / Piperazine Derivatives
ES2483898T3 (en) 2007-06-08 2014-08-08 Janssen Pharmaceutica, N.V. Piperidine / Piperazine Derivatives
PE20140572A1 (en) 2008-06-05 2014-05-16 Janssen Pharmaceutica Nv DRUG COMBINATIONS INCLUDING A DGAT INHIBITOR AND A PPAR AGONIST
EP2404902A1 (en) * 2009-03-05 2012-01-11 Shionogi&Co., Ltd. Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
JP2022537140A (en) * 2019-06-14 2022-08-24 エスアールエックス カーディオ，エル エル シー Compounds for modulating proprotein convertase subtilisin/kexin type 9 (PCSK9)
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)

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MA26732A1 (en) 2004-12-20
PA8494601A1 (en) 2002-08-29
WO2000071107A8 (en) 2002-01-24
NO20015651L (en) 2002-01-18
PL358538A1 (en) 2004-08-09
AR022640A1 (en) 2002-09-04
BR0010820A (en) 2002-03-05
NO20015651D0 (en) 2001-11-20
BG106208A (en) 2002-09-30
IS6126A (en) 2001-10-26
AU2935300A (en) 2000-12-12
PE20010157A1 (en) 2001-02-16
IL145955A0 (en) 2002-07-25
KR20020010916A (en) 2002-02-06
JP2003523941A (en) 2003-08-12
DZ3041A1 (en) 2004-03-27
CN1617743A (en) 2005-05-18
ZA200109555B (en) 2004-04-07
AP2001002326A0 (en) 2001-12-31
HUP0301287A2 (en) 2003-08-28
EA200101110A1 (en) 2002-08-29
HRP20010862A2 (en) 2003-06-30
WO2000071107A2 (en) 2000-11-30
HN2000000045A (en) 2001-03-02
TNSN00106A1 (en) 2005-11-10
TR200103351T2 (en) 2002-06-21
HUP0301287A3 (en) 2005-03-29
SK16602001A3 (en) 2003-03-04
EP1178784A1 (en) 2002-02-13
UY26148A1 (en) 2000-12-29
EE200100611A (en) 2003-02-17
CA2374668A1 (en) 2000-11-30
GT200000071A (en) 2001-11-08
OA11943A (en) 2006-04-12
MXPA01011978A (en) 2002-05-06

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