PE20000727A1 - Compuestos de tetrahidronaftiridinil-carboxamida - Google Patents
Compuestos de tetrahidronaftiridinil-carboxamidaInfo
- Publication number
- PE20000727A1 PE20000727A1 PE1999000519A PE00051999A PE20000727A1 PE 20000727 A1 PE20000727 A1 PE 20000727A1 PE 1999000519 A PE1999000519 A PE 1999000519A PE 00051999 A PE00051999 A PE 00051999A PE 20000727 A1 PE20000727 A1 PE 20000727A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- tetrahydronaphthyridinyl
- naphthyridin
- tetrahydro
- trimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A COMPUESTOS TETRAHIDRONAFTIRIDINIL-CARBOXAMIDA DE FORMULA I, DONDE R1 ES H, ALQUILO C1-C6 (OPCIONALMENTE SUSTITUIDO CON OH, ALCOXI C1-C4), FENIL-ALQUILO C1-C4, ALQUENILO C1-C6, ALQUINILO C1-C6; R2 ES H, HALOGENO, NO2, CN, CF3O-, CF3S-, CF3SO2, CF3CO, ALQUILO C1-C6, ENTRE OTROS; DOS DE R2 FORMAN UN CARBOCICLO OPCIONALMENTE SUSTITUIDO CON O, NH; R3 Y R4 SON H, ALQUILO C1-C6; DOS DE R3 o R4 FORMAN JUNTOS UN ESPIROALQUILO, CUANDO UNO DE R3 Y R4 NO SEA H; X ES H, HALOGENO, CIANO, ALQUILO, ALCOXI. SON COMPUESTOS PREFERIDOS N-5,6,7,8-TETRAHIDRO-6,8,8-TRIMETIL-[1,6]-NAFTIRIDIN-3-IL)BENZAMIDA; N-5,6,7,8-TETRAHIDRO-6,8,8-TRIMETIL-[1,6]-NAFTIRIDIN-3-IL)4-METOXI-3-TRIFLUOROMETILBENZAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE ANSIEDAD, MANIA, DEPRESION, ATAQUES DE PANICO, AGRESION, EPILEPSIA, MIGRANA, TRASTORNOS ASOCIADOS CON UNA HEMORRAGIA SUBARACNOIDEA O CHOQUE NEURAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9812683.2A GB9812683D0 (en) | 1998-06-12 | 1998-06-12 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000727A1 true PE20000727A1 (es) | 2000-09-28 |
Family
ID=10833636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000519A PE20000727A1 (es) | 1998-06-12 | 1999-06-11 | Compuestos de tetrahidronaftiridinil-carboxamida |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US6410555B1 (es) |
| EP (1) | EP1084122B1 (es) |
| JP (1) | JP2002518390A (es) |
| KR (1) | KR20010052792A (es) |
| CN (1) | CN1311789A (es) |
| AP (1) | AP2000002009A0 (es) |
| AR (1) | AR018656A1 (es) |
| AT (1) | ATE252579T1 (es) |
| AU (1) | AU750470B2 (es) |
| BG (1) | BG105126A (es) |
| BR (1) | BR9911110A (es) |
| CA (1) | CA2334900A1 (es) |
| CO (1) | CO5040081A1 (es) |
| CZ (1) | CZ293010B6 (es) |
| DE (1) | DE69912278T2 (es) |
| EA (1) | EA200100033A1 (es) |
| ES (1) | ES2209524T3 (es) |
| GB (1) | GB9812683D0 (es) |
| HU (1) | HUP0102773A3 (es) |
| ID (1) | ID27593A (es) |
| IL (1) | IL140171A0 (es) |
| MA (1) | MA26646A1 (es) |
| NO (1) | NO20006269L (es) |
| NZ (1) | NZ508799A (es) |
| PE (1) | PE20000727A1 (es) |
| PL (1) | PL344791A1 (es) |
| SK (1) | SK18962000A3 (es) |
| TR (1) | TR200003694T2 (es) |
| TW (1) | TW495510B (es) |
| WO (1) | WO1999065903A1 (es) |
| ZA (1) | ZA200007397B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9812683D0 (en) * | 1998-06-12 | 1998-08-12 | Smithkline Beecham Plc | Novel compounds |
| DE60100055T2 (de) * | 2001-03-21 | 2003-07-24 | Sanol Arznei Schwarz Gmbh | Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen |
| CA2624625A1 (en) * | 2005-11-04 | 2007-05-10 | Pfizer Limited | Tetrahydronaphthyridine derivative |
| JP6378182B2 (ja) * | 2012-08-27 | 2018-08-22 | アレイ バイオファーマ、インコーポレイテッド | 過剰増殖性│疾患の処置のためのセリン／スレオニンキナーゼ阻害剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9112721D0 (en) | 1991-06-13 | 1991-07-31 | Smithkline Beecham Plc | Novel treatment |
| EP0906283A1 (en) | 1996-06-17 | 1999-04-07 | Smithkline Beecham Plc | Substituted benzamide derivatives and their use as anticonvulsants |
| GB9711257D0 (en) * | 1997-05-30 | 1997-07-30 | Smithkline Beecham Plc | Novel compounds |
| GB9812683D0 (en) * | 1998-06-12 | 1998-08-12 | Smithkline Beecham Plc | Novel compounds |
-
1998
- 1998-06-12 GB GBGB9812683.2A patent/GB9812683D0/en not_active Ceased
-
1999
- 1999-06-09 AT AT99957056T patent/ATE252579T1/de not_active IP Right Cessation
- 1999-06-09 AU AU42800/99A patent/AU750470B2/en not_active Ceased
- 1999-06-09 ES ES99957056T patent/ES2209524T3/es not_active Expired - Lifetime
- 1999-06-09 DE DE69912278T patent/DE69912278T2/de not_active Expired - Fee Related
- 1999-06-09 AP APAP/P/2000/002009A patent/AP2000002009A0/en unknown
- 1999-06-09 WO PCT/GB1999/001826 patent/WO1999065903A1/en not_active Application Discontinuation
- 1999-06-09 PL PL99344791A patent/PL344791A1/xx not_active Application Discontinuation
- 1999-06-09 EP EP99957056A patent/EP1084122B1/en not_active Expired - Lifetime
- 1999-06-09 EA EA200100033A patent/EA200100033A1/ru unknown
- 1999-06-09 HU HU0102773A patent/HUP0102773A3/hu unknown
- 1999-06-09 BR BR9911110-1A patent/BR9911110A/pt not_active IP Right Cessation
- 1999-06-09 ID IDW20002580A patent/ID27593A/id unknown
- 1999-06-09 US US09/719,335 patent/US6410555B1/en not_active Expired - Fee Related
- 1999-06-09 TR TR2000/03694T patent/TR200003694T2/xx unknown
- 1999-06-09 KR KR1020007014099A patent/KR20010052792A/ko not_active Application Discontinuation
- 1999-06-09 SK SK1896-2000A patent/SK18962000A3/sk unknown
- 1999-06-09 NZ NZ508799A patent/NZ508799A/en unknown
- 1999-06-09 CN CN99809413A patent/CN1311789A/zh active Pending
- 1999-06-09 JP JP2000554728A patent/JP2002518390A/ja active Pending
- 1999-06-09 CA CA002334900A patent/CA2334900A1/en not_active Abandoned
- 1999-06-09 CZ CZ20004611A patent/CZ293010B6/cs not_active IP Right Cessation
- 1999-06-09 IL IL14017199A patent/IL140171A0/xx unknown
- 1999-06-10 MA MA25618A patent/MA26646A1/fr unknown
- 1999-06-10 AR ARP990102772A patent/AR018656A1/es not_active Application Discontinuation
- 1999-06-11 CO CO99036865A patent/CO5040081A1/es unknown
- 1999-06-11 TW TW088109749A patent/TW495510B/zh active
- 1999-06-11 PE PE1999000519A patent/PE20000727A1/es not_active Application Discontinuation
-
2000
- 2000-12-11 NO NO20006269A patent/NO20006269L/no not_active Application Discontinuation
- 2000-12-12 ZA ZA200007397A patent/ZA200007397B/xx unknown
-
2001
- 2001-01-08 BG BG105126A patent/BG105126A/xx unknown
-
2002
- 2002-05-23 US US10/154,997 patent/US6762192B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |