AR018656A1 - Compuesto de tetrahidronaftiridinil-carboxamida, composicion farmaceutica que lo contiene, su uso para la manufactura de un medicamento y procedimientopara su preparacion - Google Patents
Compuesto de tetrahidronaftiridinil-carboxamida, composicion farmaceutica que lo contiene, su uso para la manufactura de un medicamento y procedimientopara su preparacionInfo
- Publication number
- AR018656A1 AR018656A1 ARP990102772A ARP990102772A AR018656A1 AR 018656 A1 AR018656 A1 AR 018656A1 AR P990102772 A ARP990102772 A AR P990102772A AR P990102772 A ARP990102772 A AR P990102772A AR 018656 A1 AR018656 A1 AR 018656A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- cycloalkyl
- phenyl
- groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Anesthesiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compuestos de tetrahidronaftiridinil-carboxamida y sus sales y solvatos farmacéuticamente aceptables de formula (I), en la que: R1 es hidrogeno,alquilo C1-6 (opcionalmente sustituido con hidroxi o alcoxi C1-4), fenil-alquilo C1-4, alquenilo C1-6, o alquinilo C1-6; R2 es hidrogeno o hasta3 sustituyentes seleccionados entre halogeno, NO2, CN, N3, CF3O-, CF3S-, CF3SO2, CF3CO-, alquilo C1-6, alquenilo C1-6, alquinilo C1-6, perfluoro-alquilo C1-6,cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-4, alquil C1-6-O-, alquil C1-6-CO, cicloalquil C3-6-O-, cicloalquil C3-6-CO-, cicloalquil C3-6-alquilC1-4-O-, cicloalquil C3-6-alquil C1-4-CO-, fenilo, fenoxi, benciloxi, benzoílo, fenil-alquilo C1-4-, alquil C1-6-S-, alquil C1-6-SO2-, (alquil C1-4)2NSO2-,(alquil C1-4)-NHSO2-, (alquil C1-4)2NCO, (alquil C1-4)NHCO- o CONH2; o -NR5R6, donde R5 es hidrogeno o alquilo C1-4; y R6 es hidrogeno, alquilo C1-4,formilo, -CO2-alquilo C1-4 o -CO-alquilo C1-4;o dos grupos R2 juntos forman un anillo carbocíclico quees saturado o insaturado, opcionalmenteinterrumpido con O o NH; los grupos R3 y R4 son independientemente en cada caso hidrogeno o alquilo C1-6 y/o los dos grupos R3 y/o los dos grupos R4 juntosforman un grupo espiroalquilo, siempre que al menos ungrupo R3 y R4 no sea hidrogeno; y X se selecciona entre hidrogeno, halogeno, ciano, alquilo y alcoxi;composicion farmacéutica que lo contiene, su uso para la manufactura de un medicamento y procedimiento para su preparacion. Estos compuestos detetrahidronaftiridinil-carboxamida poseen actividad anticonvulsiva y, por tanto, se cree que son utiles en el tratamiento y/o la prevencion de ansiedad,manía, depresion, ataques de pánico y/o agresion, trastornos asociados con una hemorragia subaracnoideao choque neural, los efectos asociados conel abandono de drogas tales como cocaína, nicotina, alcohol y benzodiazepinas, trastornos tratables y/o prevenibles con agentes anticonvulsivos,tales como epilepsia, incluyendo la epilepsia post-traumática, enfermedad de Parkinson, psicosis, migrana, isquemia cerebral, enfermedad de Alzheimer, y
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9812683.2A GB9812683D0 (en) | 1998-06-12 | 1998-06-12 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018656A1 true AR018656A1 (es) | 2001-11-28 |
Family
ID=10833636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102772A AR018656A1 (es) | 1998-06-12 | 1999-06-10 | Compuesto de tetrahidronaftiridinil-carboxamida, composicion farmaceutica que lo contiene, su uso para la manufactura de un medicamento y procedimientopara su preparacion |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US6410555B1 (es) |
| EP (1) | EP1084122B1 (es) |
| JP (1) | JP2002518390A (es) |
| KR (1) | KR20010052792A (es) |
| CN (1) | CN1311789A (es) |
| AP (1) | AP2000002009A0 (es) |
| AR (1) | AR018656A1 (es) |
| AT (1) | ATE252579T1 (es) |
| AU (1) | AU750470B2 (es) |
| BG (1) | BG105126A (es) |
| BR (1) | BR9911110A (es) |
| CA (1) | CA2334900A1 (es) |
| CO (1) | CO5040081A1 (es) |
| CZ (1) | CZ293010B6 (es) |
| DE (1) | DE69912278T2 (es) |
| EA (1) | EA200100033A1 (es) |
| ES (1) | ES2209524T3 (es) |
| GB (1) | GB9812683D0 (es) |
| HU (1) | HUP0102773A3 (es) |
| ID (1) | ID27593A (es) |
| IL (1) | IL140171A0 (es) |
| MA (1) | MA26646A1 (es) |
| NO (1) | NO20006269L (es) |
| NZ (1) | NZ508799A (es) |
| PE (1) | PE20000727A1 (es) |
| PL (1) | PL344791A1 (es) |
| SK (1) | SK18962000A3 (es) |
| TR (1) | TR200003694T2 (es) |
| TW (1) | TW495510B (es) |
| WO (1) | WO1999065903A1 (es) |
| ZA (1) | ZA200007397B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9812683D0 (en) * | 1998-06-12 | 1998-08-12 | Smithkline Beecham Plc | Novel compounds |
| EP1243263B1 (en) * | 2001-03-21 | 2002-11-27 | Schwarz Pharma Ag | Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain |
| CA2624625A1 (en) * | 2005-11-04 | 2007-05-10 | Pfizer Limited | Tetrahydronaphthyridine derivative |
| AR092253A1 (es) * | 2012-08-27 | 2015-04-08 | Array Biopharma Inc | Inhibidores de serina/treonina cinasa |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9112721D0 (en) * | 1991-06-13 | 1991-07-31 | Smithkline Beecham Plc | Novel treatment |
| BR9709906A (pt) * | 1996-06-17 | 1999-08-10 | Smithkline Beecham Plc | Derivados de benzamida substituídos e o uso dos mesmos como anticonvulsivantes |
| GB9711257D0 (en) * | 1997-05-30 | 1997-07-30 | Smithkline Beecham Plc | Novel compounds |
| GB9812683D0 (en) * | 1998-06-12 | 1998-08-12 | Smithkline Beecham Plc | Novel compounds |
-
1998
- 1998-06-12 GB GBGB9812683.2A patent/GB9812683D0/en not_active Ceased
-
1999
- 1999-06-09 ID IDW20002580A patent/ID27593A/id unknown
- 1999-06-09 EA EA200100033A patent/EA200100033A1/ru unknown
- 1999-06-09 AP APAP/P/2000/002009A patent/AP2000002009A0/en unknown
- 1999-06-09 KR KR1020007014099A patent/KR20010052792A/ko not_active Application Discontinuation
- 1999-06-09 SK SK1896-2000A patent/SK18962000A3/sk unknown
- 1999-06-09 JP JP2000554728A patent/JP2002518390A/ja active Pending
- 1999-06-09 CZ CZ20004611A patent/CZ293010B6/cs not_active IP Right Cessation
- 1999-06-09 AU AU42800/99A patent/AU750470B2/en not_active Ceased
- 1999-06-09 DE DE69912278T patent/DE69912278T2/de not_active Expired - Fee Related
- 1999-06-09 NZ NZ508799A patent/NZ508799A/en unknown
- 1999-06-09 HU HU0102773A patent/HUP0102773A3/hu unknown
- 1999-06-09 PL PL99344791A patent/PL344791A1/xx not_active Application Discontinuation
- 1999-06-09 ES ES99957056T patent/ES2209524T3/es not_active Expired - Lifetime
- 1999-06-09 WO PCT/GB1999/001826 patent/WO1999065903A1/en not_active Application Discontinuation
- 1999-06-09 CN CN99809413A patent/CN1311789A/zh active Pending
- 1999-06-09 TR TR2000/03694T patent/TR200003694T2/xx unknown
- 1999-06-09 BR BR9911110-1A patent/BR9911110A/pt not_active IP Right Cessation
- 1999-06-09 IL IL14017199A patent/IL140171A0/xx unknown
- 1999-06-09 CA CA002334900A patent/CA2334900A1/en not_active Abandoned
- 1999-06-09 AT AT99957056T patent/ATE252579T1/de not_active IP Right Cessation
- 1999-06-09 EP EP99957056A patent/EP1084122B1/en not_active Expired - Lifetime
- 1999-06-09 US US09/719,335 patent/US6410555B1/en not_active Expired - Fee Related
- 1999-06-10 AR ARP990102772A patent/AR018656A1/es not_active Application Discontinuation
- 1999-06-10 MA MA25618A patent/MA26646A1/fr unknown
- 1999-06-11 CO CO99036865A patent/CO5040081A1/es unknown
- 1999-06-11 PE PE1999000519A patent/PE20000727A1/es not_active Application Discontinuation
- 1999-06-11 TW TW088109749A patent/TW495510B/zh active
-
2000
- 2000-12-11 NO NO20006269A patent/NO20006269L/no not_active Application Discontinuation
- 2000-12-12 ZA ZA200007397A patent/ZA200007397B/xx unknown
-
2001
- 2001-01-08 BG BG105126A patent/BG105126A/xx unknown
-
2002
- 2002-05-23 US US10/154,997 patent/US6762192B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |