PE20050393A1 - Compuestos de benzopirano para uso en el tratamiento y la prevencion de afecciones relacionadas con la inflamacion - Google Patents

Compuestos de benzopirano para uso en el tratamiento y la prevencion de afecciones relacionadas con la inflamacion

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Publication number
PE20050393A1
PE20050393A1 PE2004000343A PE2004000343A PE20050393A1 PE 20050393 A1 PE20050393 A1 PE 20050393A1 PE 2004000343 A PE2004000343 A PE 2004000343A PE 2004000343 A PE2004000343 A PE 2004000343A PE 20050393 A1 PE20050393 A1 PE 20050393A1
Authority
PE
Peru
Prior art keywords
inflammation
compounds
treatment
carboxyl
acid
Prior art date
Application number
PE2004000343A
Other languages
English (en)
Inventor
Steven W Kramer
Subo Liao
John R Springer
Jr James R Kiefer
Francis Koszyk
Angela M Deprow
E Ann Hallinan
Davil L Brown
Yi Yu
Li Xing
Lijuan Jane Wang
Jeffrey S Carter
Bruce C Hamper
Theresa R Fletcher
Karl W Aston
Sofya Tsymbalov
Renne M Huff
David Limburg
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of PE20050393A1 publication Critical patent/PE20050393A1/es

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  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE BENZOPIRANO DE FORMULA (I), DONDE X ES H, ALQUILO O UN CATION FARMACEUTICAMENTE ACEPTABLE; Z ES O, S O NH; R1, R2, R3, Y R4 SON, INDEPENDIENTEMENTE H, ALQUENILALQUINILO, ALQUENILOXI, ALCOXI, ALCOXIALCOXI, ENTRE OTROS O R1 Y R2, R2 Y R3 O R3 Y R4, PUEDEN FORMAR OPCIONALMENTE, JUNTO CON LOS ATOMOS A LOS QUE ESTAN UNIDOS, UN ANILLO CICLOALQUILO O UN ANILLO HETEROARILO LOS QUE PUEDEN ESTAR OPCIONALMENTE SUSTITUIDOS POR ALQUILO. SON COMPUESTOS PREFERIDOS: ACIDO 7-(4-BROMOFENOXI)-6-CLORO-2-(TRIFLUOROMETIL)-2H-CROMENO-3-CARBOXILICO, ACIDO 6-CLORO-7-(4-ETIL-2-FLUOROFENOXI)-2-(TRIFLUOROMETIL)-2H-CROMENO-3-CARBOXILICO, ACIDO 6,8-DICLORO 7-(CICLOPENTILMETOXI)-2-(TRIFLUOROMETIL)-2H-CROMENO-3-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICON FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE CICLOOXIGENASA-2 Y SON UTILES EN EL TRATAMIENTO DE LA INFLAMACION Y TRASTORNOS RELACIONADOS CON LA INFLAMACION
PE2004000343A 2003-03-31 2004-03-31 Compuestos de benzopirano para uso en el tratamiento y la prevencion de afecciones relacionadas con la inflamacion PE20050393A1 (es)

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US6034256A (en) * 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
CA2574363A1 (en) * 2004-07-23 2006-02-02 Pharmacia & Upjohn Company Llc Enantioselective method for separating sustituted 2-trifluoromethyl-2h-chromene-3-carboxylic acid derivatives
WO2006011052A1 (en) * 2004-07-23 2006-02-02 Pharmacia & Upjohn Company Llc Method for the racemization of 2-trifluoro-2h-chromene-3-carboxylic acids
JP2008507501A (ja) * 2004-07-23 2008-03-13 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー ２−トリフルオロメチル−２ｈ−クロメン−３−カルボン酸誘導体の光ラセミ化
WO2006040676A1 (en) * 2004-10-12 2006-04-20 Pharmacia & Upjohn Company Llc Nitrosated benzopyran compounds as novel cyclooxygenase-2 selective inhibitors
GB0608825D0 (en) * 2006-05-04 2006-06-14 Glaxo Group Ltd Compounds
CN102757417B (zh) * 2012-06-18 2014-09-24 中国科学院广州生物医药与健康研究院 氘代苯并吡喃类化合物及其应用
JP6061373B2 (ja) * 2012-07-24 2017-01-18 国立研究開発法人産業技術総合研究所 ２−ヒドロキシベンズアルデヒド化合物、これを含有するコラーゲン細胞外分泌阻害剤及び医薬品組成物
CN103012350B (zh) * 2012-12-07 2015-02-04 中国科学院广州生物医药与健康研究院 苯并吡喃类手性化合物的合成方法
WO2015109013A1 (en) * 2014-01-14 2015-07-23 Euclises Pharmaceuticals, Inc. Deuterated no-releasing nitrooxy-chromene conjugates
EP3126451B1 (en) 2014-04-01 2020-09-09 Howard Hughes Medical Institute Azetidine-substituted fluorescent compounds
CN107810206B (zh) * 2015-06-19 2021-01-19 Sabic环球技术有限责任公司 用于烯烃聚合的包含特定比率的氨基苯甲酸酯内给体和1,3-二醚内给体的主催化剂
GB2543550A (en) 2015-10-21 2017-04-26 Hox Therapeutics Ltd Peptides
EP3894402B1 (en) * 2018-12-14 2023-07-05 F. Hoffmann-La Roche AG N-containing chromen-4-one derivatives for the treatment and prophylaxis of hepatitis b virus infection

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US6034256A (en) * 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation

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CA2519291A1 (en) 2004-10-14
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BRPI0408389A (pt) 2006-03-01
MXPA05010423A (es) 2006-04-24
NL1025844A1 (nl) 2004-10-01
TW200504045A (en) 2005-02-01
UY28247A1 (es) 2004-11-08
AR043951A1 (es) 2005-08-17
WO2004087687A1 (en) 2004-10-14
EP1631562A1 (en) 2006-03-08
PA8599301A1 (es) 2004-12-16
US20050148627A1 (en) 2005-07-07
CL2004000664A1 (es) 2005-02-04

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