PE1499A1 - Proceso de microencapsulacion que utiliza fluidos supercriticos - Google Patents

Proceso de microencapsulacion que utiliza fluidos supercriticos

Info

Publication number
PE1499A1
PE1499A1 PE1997000889A PE00088997A PE1499A1 PE 1499 A1 PE1499 A1 PE 1499A1 PE 1997000889 A PE1997000889 A PE 1997000889A PE 00088997 A PE00088997 A PE 00088997A PE 1499 A1 PE1499 A1 PE 1499A1
Authority
PE
Peru
Prior art keywords
supercritical
polymer
thermolabil
poly
pressure
Prior art date
Application number
PE1997000889A
Other languages
English (en)
Inventor
Annette Dudek Shine
Jr Jack Gelb
Original Assignee
Univ Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Delaware filed Critical Univ Delaware
Publication of PE1499A1 publication Critical patent/PE1499A1/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

QUE COMPRENDE: A) MEZCLAR UN POLIMERO ALIFATICO SELECCIONADO ENTRE EL GRUPO QUE CONSISTE EN POLICAPROLACTONA, ACIDO (POLI)GLICOLICO, ACIDO (POLI)LACTICO, POLI(HIDROXIBUTIRATO), POLI(HIDROXIVALERATO), ADIPATO DE (POLI)ETILENO, COPOLIMEROS DE ACIDO LACTICO/GLICOLICO, COPOLIMEROS DE HIDROXIBUTIRATO/HIDROXIVALERATO MICROENCAPSULADO CON UN FLUIDO SUPERCRITICO QUE PUEDE SER N20 SUPERCRITICO O C02 SUPERCRITICO CON CAPACIDADES PARA DISOLVER EL POLIMERO PERO NO EL MATERIAL DE NUCLEO QUE PUEDE COMPRENDER UN ANTIBIOTICO, UN ANALGESICO, UN AGENTE TERAPEUTICO O UNA VACUNA QUE COMPRENDE UN VIRUS NO RECUBIERTO, PRODUCIENDOSE LA MEZCLA A PRESION Y TEMPERATURA ADECUADAS PARA MANTENER EL FLUIDO EN ESTADO SUPERCRITICO Y A UNA TEMPERATURA SUFICIENTE PARA LICUAR EL POLIMERO; B) SOBREENFRIAR EL POLIMERO LICUADO A UNA TEMPERATURA INFERIOR A AQUELLA EN LA CUAL EL MATERIAL DE NUCLEO TERMOLABIL RESULTA ADVERSAMENTE AFECTADO; C) MEZCLAR EL MATERIAL TERMOLABIL CON EL POLIMERO LICUADO SOBREENFRIADO MIENTRAS SE MANTIENEN UNA TEMPERATURA Y PRESION SUFICIENTES PARA MANTENER EL FLUIDO SUPERCRITICO EN ESTADO SUPERCRITICO; Y D) LIBERAR LA PRESION PARA SOLIDIFICAR EL POLIMERO ALREDEDOR DEL MATERIAL TERMOLABIL A FIN DE FORMAR MICROCAPSULAS
PE1997000889A 1996-10-08 1997-10-07 Proceso de microencapsulacion que utiliza fluidos supercriticos PE1499A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/727,154 US5766637A (en) 1996-10-08 1996-10-08 Microencapsulation process using supercritical fluids

Publications (1)

Publication Number Publication Date
PE1499A1 true PE1499A1 (es) 1999-02-11

Family

ID=24921541

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000889A PE1499A1 (es) 1996-10-08 1997-10-07 Proceso de microencapsulacion que utiliza fluidos supercriticos

Country Status (14)

Country Link
US (1) US5766637A (es)
EP (1) EP0948396A1 (es)
JP (1) JP2000511110A (es)
CN (1) CN1232411A (es)
AR (1) AR008867A1 (es)
AU (1) AU713965B2 (es)
BR (1) BR9711590A (es)
CA (1) CA2267350A1 (es)
CO (1) CO4900026A1 (es)
IN (1) IN183694B (es)
NO (1) NO991571L (es)
NZ (1) NZ334815A (es)
PE (1) PE1499A1 (es)
WO (1) WO1998015348A1 (es)

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Also Published As

Publication number Publication date
EP0948396A1 (en) 1999-10-13
NO991571D0 (no) 1999-03-30
AU713965B2 (en) 1999-12-16
WO1998015348A1 (en) 1998-04-16
NZ334815A (en) 2001-01-26
AR008867A1 (es) 2000-02-23
US5766637A (en) 1998-06-16
CA2267350A1 (en) 1998-04-16
NO991571L (no) 1999-06-07
CN1232411A (zh) 1999-10-20
AU4602797A (en) 1998-05-05
BR9711590A (pt) 1999-08-24
IN183694B (es) 2000-03-18
JP2000511110A (ja) 2000-08-29
CO4900026A1 (es) 2000-03-27

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