ES2119450T3 - Procedimiento para la obtencion de perlas y perlas obtenidas que contienen un principio activo que presenta un punto de fusion no definido. - Google Patents

Procedimiento para la obtencion de perlas y perlas obtenidas que contienen un principio activo que presenta un punto de fusion no definido.

Info

Publication number
ES2119450T3
ES2119450T3 ES95921874T ES95921874T ES2119450T3 ES 2119450 T3 ES2119450 T3 ES 2119450T3 ES 95921874 T ES95921874 T ES 95921874T ES 95921874 T ES95921874 T ES 95921874T ES 2119450 T3 ES2119450 T3 ES 2119450T3
Authority
ES
Spain
Prior art keywords
pearls
active principle
tower
presenting
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95921874T
Other languages
English (en)
Inventor
Michel Deleuil
Thiesse Jean-Claude Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2119450T3 publication Critical patent/ES2119450T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Glanulating (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Dental Preparations (AREA)
  • Steroid Compounds (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN NUEVO PROCEDIMIENTO DE PREPARACION DE PERLAS DE UN COMPUESTO QUE PRESENTA UN PUNTO DE CRISTALIZACION NO DEFINIDO QUE PRESENTA UN PERFIL DE LIBERACION RAPIDA Y/O PROLONGADA. SE REFIERE TAMBIEN A PERLAS OBTENIDAS POR EL PROCEDIMIENTO. EL PROCEDIMIENTO CONSISTE EN INTRODUCIR EN UN RECIPIENTE DE ALIMENTACION DE UNA TORRE DE "PRILLING" EL PRINCIPIO ACTIVO QUE PRESENTA UN PUNTO DE FUSION NO DEFINIDO Y UN EXCIPIENTE DE CRISTALIZACION, EN PASAR LA MEZCLA A TRAVES DE UNA BOQUILLA VIBRADA PARA FORMAR LAS PERLAS QUE SE DEJAN CAER EN LA TORRE A CONTRACORRIENTE CON AIRE FRIO, EN PROPORCIONAR EN LA BASE DE LA TORRE UN LECHO FLUIDIZADO CUYA TEMPERATURA SE MANTIENE POR DEBAJO DE LA TEMPERATURA DE TRANSICION VITREA DEL PRINCIPIO ACTIVO QUE PRESENTA UN PUNTO DE FUSION NO DEFINIDO Y POR DEBAJO DE LA TEMPERATURA DEL INICIO DE LICUEFACCION DEL EXCIPIENTE.
ES95921874T 1994-06-03 1995-06-01 Procedimiento para la obtencion de perlas y perlas obtenidas que contienen un principio activo que presenta un punto de fusion no definido. Expired - Lifetime ES2119450T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9406842A FR2720631B1 (fr) 1994-06-03 1994-06-03 Procédé de préparation et perles obtenues contenant un principe actif présentant un point de fusion non défini.

Publications (1)

Publication Number Publication Date
ES2119450T3 true ES2119450T3 (es) 1998-10-01

Family

ID=9463876

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95921874T Expired - Lifetime ES2119450T3 (es) 1994-06-03 1995-06-01 Procedimiento para la obtencion de perlas y perlas obtenidas que contienen un principio activo que presenta un punto de fusion no definido.

Country Status (21)

Country Link
US (1) US6074580A (es)
EP (1) EP0762865B1 (es)
JP (1) JP3777556B2 (es)
CN (1) CN1149824A (es)
AT (1) ATE169210T1 (es)
AU (1) AU693561B2 (es)
BR (1) BR9507879A (es)
CA (1) CA2190395A1 (es)
CZ (1) CZ352296A3 (es)
DE (1) DE69503901T2 (es)
DK (1) DK0762865T3 (es)
ES (1) ES2119450T3 (es)
FI (1) FI112599B (es)
FR (1) FR2720631B1 (es)
GR (1) GR3027592T3 (es)
HU (1) HUT76712A (es)
NO (1) NO965081D0 (es)
NZ (1) NZ287894A (es)
PL (1) PL317428A1 (es)
SK (1) SK153996A3 (es)
WO (1) WO1995033433A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19834064A1 (de) * 1998-07-29 2000-02-03 Zentis Gmbh & Co Franz Verfahren und Vorrichtung zur Herstellung von Partikeln eines Lebensmittels
DE19845126A1 (de) * 1998-09-30 2000-04-06 Marco Systemanalyse Entw Verfahren zur Tropfenbildung
DE10019508A1 (de) * 2000-04-19 2001-10-31 Rieter Automatik Gmbh Verfahren und Vorrichtung zur Vertropfung von Vorprodukten thermoplastischer Polyester oder Copolyester
US20030195179A1 (en) * 2000-08-25 2003-10-16 Shirou Sawa Aqueous suspension preparations
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
CN100431515C (zh) * 2005-05-24 2008-11-12 浙江大学 稳定微粒化药物添加剂的制备方法
US10077518B2 (en) * 2008-10-29 2018-09-18 Mitsui Chemicals, Inc. Crimped conjugated fiber and nonwoven fabric comprising the same
JP6735630B2 (ja) * 2016-08-10 2020-08-05 バイオ科学株式会社 ルーメンバイパス製剤の製造方法とこれにより得られた顆粒剤
JP7049693B2 (ja) * 2020-05-29 2022-04-07 バイオ科学株式会社 ルーメンバイパス製剤の製造方法とこれにより得られた顆粒剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE628183A (es) *
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.

Also Published As

Publication number Publication date
BR9507879A (pt) 1997-08-12
DE69503901D1 (de) 1998-09-10
EP0762865A1 (fr) 1997-03-19
CA2190395A1 (fr) 1995-12-14
FI112599B (fi) 2003-12-31
AU693561B2 (en) 1998-07-02
HU9603319D0 (en) 1997-01-28
CZ352296A3 (en) 1997-03-12
US6074580A (en) 2000-06-13
NZ287894A (en) 1998-07-28
GR3027592T3 (en) 1998-11-30
FI964811A0 (fi) 1996-12-02
ATE169210T1 (de) 1998-08-15
WO1995033433A1 (fr) 1995-12-14
NO965081L (no) 1996-11-28
FR2720631A1 (fr) 1995-12-08
PL317428A1 (en) 1997-04-14
CN1149824A (zh) 1997-05-14
EP0762865B1 (fr) 1998-08-05
FR2720631B1 (fr) 1996-07-12
JP3777556B2 (ja) 2006-05-24
HUT76712A (en) 1997-10-28
NO965081D0 (no) 1996-11-28
JPH10500899A (ja) 1998-01-27
SK153996A3 (en) 1997-07-09
FI964811A (fi) 1996-12-02
AU2676495A (en) 1996-01-04
DE69503901T2 (de) 1999-03-18
DK0762865T3 (da) 1998-11-16

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