PA8779801A1 - Derivados heterocíclicos sustituidos y su uso farmacéutico y composiciones - Google Patents
Derivados heterocíclicos sustituidos y su uso farmacéutico y composicionesInfo
- Publication number
- PA8779801A1 PA8779801A1 PA20088779801A PA8779801A PA8779801A1 PA 8779801 A1 PA8779801 A1 PA 8779801A1 PA 20088779801 A PA20088779801 A PA 20088779801A PA 8779801 A PA8779801 A PA 8779801A PA 8779801 A1 PA8779801 A1 PA 8779801A1
- Authority
- PA
- Panama
- Prior art keywords
- compositions
- pharmaceutical use
- heterocyclic derivatives
- derivatives substituted
- substituted
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91690607P | 2007-05-09 | 2007-05-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8779801A1 true PA8779801A1 (es) | 2009-01-23 |
Family
ID=39865577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20088779801A PA8779801A1 (es) | 2007-05-09 | 2008-05-09 | Derivados heterocíclicos sustituidos y su uso farmacéutico y composiciones |
Country Status (17)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120189546A1 (en) * | 2009-07-11 | 2012-07-26 | Bayer Pharma Aktiengesellschaft | Radiolabelling Method Using Cycloalkyl Groups |
| MA41169A (fr) | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
| US10633366B2 (en) | 2016-06-08 | 2020-04-28 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Antibacterial compounds |
| JP6755775B2 (ja) * | 2016-11-04 | 2020-09-16 | 富士アミドケミカル株式会社 | ４−フルオロイソキノリンの製法 |
| CN112147257B (zh) * | 2017-03-24 | 2022-06-03 | 上海安谱实验科技股份有限公司 | Pet制品中多环芳烃的提取方法 |
| MA51432A (fr) * | 2017-12-26 | 2020-11-04 | Cytokinetics Inc | Procédé de préparation d'une amino-pyrimidine et de ses intermédiaires |
| BR112021008741A2 (pt) | 2018-11-09 | 2021-08-10 | Vivace Therapeutics, Inc. | compostos bicíclicos |
| TWI849107B (zh) | 2019-04-16 | 2024-07-21 | 美商維瓦斯治療公司 | 雙環化合物 |
| CN111848423B (zh) * | 2019-04-30 | 2022-10-14 | 尚科生物医药（上海）有限公司 | 3-氧代环丁基氨基甲酸叔丁酯的制备方法 |
| US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
| US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
| AU2021300429A1 (en) | 2020-07-02 | 2023-02-16 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| TW202302589A (zh) | 2021-02-25 | 2023-01-16 | 美商英塞特公司 | 作為ｊａｋ２ ｖ６１７ｆ抑制劑之螺環內醯胺 |
| TW202334089A (zh) | 2021-11-02 | 2023-09-01 | 美商夫雷爾醫療公司 | Ｐｐａｒｇ反向激動劑及其用途 |
| CN119173514A (zh) | 2022-03-17 | 2024-12-20 | 因赛特公司 | 作为jak2 v617f抑制剂的三环脲化合物 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3869461A (en) * | 1968-07-02 | 1975-03-04 | Hoffmann La Roche | Intermediates for quinine, quinidine and derivatives thereof |
| US4096146A (en) * | 1968-07-02 | 1978-06-20 | Hoffmann-La Roche Inc. | 4-[5(R)-Alkyl(or alkenyl)-4(S)-quinuclidin-2(S) or 2(R)-ylcarbonyl]-quinolines, antipodes or racemates thereof and processes for their preparation |
| US3828048A (en) * | 1970-10-14 | 1974-08-06 | Res Et D Applic Scient Sogeras | Alkylsulfonic derivatives of quinine alkaloids |
| US4002757A (en) * | 1974-12-26 | 1977-01-11 | A. H. Robins Company, Incorporated | N-(1-substituted-3-pyrrolidinyl)-4-quinolinecarboxamides |
| PT66682B (pt) * | 1976-06-18 | 1978-11-15 | Ind Biolog Francaise | /(quinolyl-4)-propyl-1/-4 piperidines leur preparation et leur utilisation comme medicaments /(quinolyl-4)-propyl/-4 piperidines leur preparation et leur utilisation comme medicaments |
| NL7908031A (nl) * | 1979-11-01 | 1981-06-01 | Acf Chemiefarma Nv | Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen. |
| FR2471981A1 (fr) * | 1979-12-21 | 1981-06-26 | Pharmindustrie | Nouveaux derives de la (piperidyl-4)-2 (quinolyl-4)-1 ethanone, produits intermediaires et procedes pour leur preparation, et leur utilisation comme medicaments |
| FR2495470A1 (fr) * | 1980-12-05 | 1982-06-11 | Pharmindustrie | Nouveaux medicaments a base de derives de (quinolyl-4)-1 (piperidyl-4)-2 ethanol ou (quinolyl-4)-1 (piperidyl-4)-3 propanol |
| US4757079A (en) * | 1986-06-24 | 1988-07-12 | Dynamac Corporaton | Anti-hypertensive piperidine compounds |
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| US5260331A (en) * | 1989-01-02 | 1993-11-09 | John Wyeth & Brother Limited | Composition for treating depression with (S- or O-heteroaryl)alkyl amines |
| FR2642069B1 (fr) * | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FI915717A0 (fi) * | 1990-04-06 | 1991-12-04 | Eisai Co Ltd | Fast oral preparat som innehaoller katekolfoerening. |
| JPH0772176B2 (ja) * | 1991-04-03 | 1995-08-02 | コリア リサーチ インスティチュート オブ ケミカル テクノロジイ | ２―キノリノン誘導体 |
| CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
| GB9216297D0 (en) * | 1991-08-15 | 1992-09-16 | Ici Plc | Therapeutic agents |
| FR2695126B1 (fr) * | 1992-08-27 | 1994-11-10 | Sanofi Elf | Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant. |
| DE4321030A1 (de) * | 1993-06-24 | 1995-01-05 | Bayer Ag | 4-bicyclisch substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimittel |
| GB9318691D0 (en) * | 1993-09-09 | 1993-10-27 | Merck Sharp & Dohme | Therapeutic agents |
| US5512581A (en) * | 1994-07-18 | 1996-04-30 | Abbott Laboratories | Iminoxycarboxylates and derivatives as inhibitors of leukotriene biosynthesis |
| US6083977A (en) * | 1994-12-30 | 2000-07-04 | Ligand Pharmaceuticals Incorporated | Trienoic retinoid compounds and methods |
| US5741789A (en) * | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| EP0876345B1 (en) * | 1995-10-16 | 2004-08-18 | Fujisawa Pharmaceutical Co., Ltd. | Heterocyclic compounds as h+-atpases |
| DE19613329A1 (de) * | 1996-04-03 | 1997-10-09 | Hoechst Schering Agrevo Gmbh | Substituierte Pyridine/Pyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| EP0901489A1 (en) * | 1996-05-20 | 1999-03-17 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| US6147088A (en) * | 1996-05-20 | 2000-11-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EP0918522A4 (en) * | 1996-05-20 | 1999-08-18 | Merck & Co Inc | GONADOLIBERIN ANTAGONISTS |
| AU722662B2 (en) * | 1996-05-20 | 2000-08-10 | Darwin Discovery Limited | Quinoline sulfonamides as TNF inhibitors and as PDE-IV inhibitors |
| HRP970371A2 (en) * | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| WO1998013350A1 (en) * | 1996-09-25 | 1998-04-02 | Zeneca Limited | Qinoline derivatives inhibiting the effect of growth factors such as vegf |
| US6274598B1 (en) * | 1996-10-28 | 2001-08-14 | The United States Of America As Represented By The Secretary Of The Army | Methods for treating antibiotic-resistant infections |
| US6767991B1 (en) * | 1997-08-11 | 2004-07-27 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C inhibitor peptides |
| GB9800569D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| DE69908555T2 (de) | 1998-01-26 | 2004-05-06 | Smithkline Beecham P.L.C., Brentford | Chinolinderivate als antibakterielles arzneimittel |
| US6172087B1 (en) * | 1998-06-03 | 2001-01-09 | Gpi Nil Holding, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
| US6303627B1 (en) * | 1998-06-19 | 2001-10-16 | Eli Lilly And Company | Inhibitors of serotonin reuptake |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| GB9819384D0 (en) * | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| GB9822440D0 (en) * | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| GB9822450D0 (en) * | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| EP1144404A1 (en) * | 1999-01-20 | 2001-10-17 | Smithkline Beecham Plc | Piperidinylquinolines as protein tyrosine kinase inhibitors |
| GB9910580D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| GB9910579D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| US6403610B1 (en) * | 1999-09-17 | 2002-06-11 | Aventis Pharma S.A. | Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them |
| FR2798656B1 (fr) * | 1999-09-17 | 2004-12-17 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
| ATE449084T1 (de) * | 2000-03-31 | 2009-12-15 | Nippon Shinyaku Co Ltd | Derivate von heterocyclen und arzneistoffe |
| US6803369B1 (en) * | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
| DE60132937T2 (de) * | 2000-09-11 | 2009-02-12 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Verfahren zur Herstellung von Benzimidazol-2-yl -Chinolinonderivaten |
| US6603005B2 (en) * | 2000-11-15 | 2003-08-05 | Aventis Pharma S.A. | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them |
| US6693125B2 (en) * | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
| US6650463B2 (en) * | 2001-03-13 | 2003-11-18 | Seiko Epson Corporation | Electrophoretic display device |
| US6602884B2 (en) * | 2001-03-13 | 2003-08-05 | Aventis Pharma S.A. | Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0118238D0 (en) | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| AU2003210493A1 (en) * | 2002-01-15 | 2003-07-30 | Michigan State University | Catalytic osmium-assisted oxidative cleavage of olefins |
| FR2842807A1 (fr) * | 2002-07-23 | 2004-01-30 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant |
| DE10316081A1 (de) * | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| US7348434B2 (en) | 2003-08-08 | 2008-03-25 | Antony Bigot | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| FR2867472B1 (fr) | 2004-03-12 | 2008-07-18 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1943222A1 (de) * | 2005-10-13 | 2008-07-16 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | 5-chinolinderivate mit antibakterieller aktivität |
-
2008
- 2008-04-29 AU AU2008249745A patent/AU2008249745B2/en not_active Ceased
- 2008-04-29 CN CN200880020428A patent/CN101679357A/zh active Pending
- 2008-04-29 JP JP2010507014A patent/JP2010526130A/ja not_active Withdrawn
- 2008-04-29 WO PCT/IB2008/001076 patent/WO2008139288A2/en not_active Ceased
- 2008-04-29 EP EP12165102A patent/EP2481735A1/en not_active Withdrawn
- 2008-04-29 CA CA002685888A patent/CA2685888A1/en not_active Abandoned
- 2008-04-29 MX MX2009012117A patent/MX2009012117A/es not_active Application Discontinuation
- 2008-04-29 KR KR1020127000612A patent/KR20120011093A/ko not_active Withdrawn
- 2008-04-29 KR KR1020097025640A patent/KR20090130347A/ko not_active Ceased
- 2008-04-29 EP EP08737576A patent/EP2155716A2/en not_active Withdrawn
- 2008-05-07 PE PE2008000800A patent/PE20090240A1/es not_active Application Discontinuation
- 2008-05-07 AR ARP080101937A patent/AR066478A1/es not_active Application Discontinuation
- 2008-05-08 UY UY31071A patent/UY31071A1/es not_active Application Discontinuation
- 2008-05-08 US US12/117,071 patent/US20080280879A1/en not_active Abandoned
- 2008-05-08 TW TW097117046A patent/TW200902518A/zh unknown
- 2008-05-09 CL CL2008001367A patent/CL2008001367A1/es unknown
- 2008-05-09 PA PA20088779801A patent/PA8779801A1/es unknown
-
2009
- 2009-10-29 IL IL201830A patent/IL201830A0/en unknown
- 2009-11-04 ZA ZA200907761A patent/ZA200907761B/xx unknown
-
2010
- 2010-12-20 US US12/972,620 patent/US20110092480A1/en not_active Abandoned
-
2011
- 2011-11-22 US US13/302,151 patent/US20120065188A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200902518A (en) | 2009-01-16 |
| WO2008139288A2 (en) | 2008-11-20 |
| MX2009012117A (es) | 2009-11-23 |
| ZA200907761B (en) | 2010-08-25 |
| KR20090130347A (ko) | 2009-12-22 |
| AR066478A1 (es) | 2009-08-19 |
| US20120065188A1 (en) | 2012-03-15 |
| KR20120011093A (ko) | 2012-02-06 |
| CA2685888A1 (en) | 2008-11-20 |
| JP2010526130A (ja) | 2010-07-29 |
| WO2008139288A3 (en) | 2009-03-26 |
| CN101679357A (zh) | 2010-03-24 |
| AU2008249745A1 (en) | 2008-11-20 |
| PE20090240A1 (es) | 2009-03-19 |
| CL2008001367A1 (es) | 2008-11-07 |
| UY31071A1 (es) | 2009-01-05 |
| IL201830A0 (en) | 2010-06-16 |
| EP2155716A2 (en) | 2010-02-24 |
| US20080280879A1 (en) | 2008-11-13 |
| US20110092480A1 (en) | 2011-04-21 |
| AU2008249745B2 (en) | 2012-01-12 |
| EP2481735A1 (en) | 2012-08-01 |
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