PA8580001A1 - Compuestos pirimido que tienen actividad antiproliferativa - Google Patents

Compuestos pirimido que tienen actividad antiproliferativa

Info

Publication number
PA8580001A1
PA8580001A1 PA20038580001A PA8580001A PA8580001A1 PA 8580001 A1 PA8580001 A1 PA 8580001A1 PA 20038580001 A PA20038580001 A PA 20038580001A PA 8580001 A PA8580001 A PA 8580001A PA 8580001 A1 PA8580001 A1 PA 8580001A1
Authority
PA
Panama
Prior art keywords
compounds
pirimid
antiproliferative activity
disclosed
selective
Prior art date
Application number
PA20038580001A
Other languages
English (en)
Inventor
Yi Chen
Jin-Jun Liu
Kin-Chun Luk
Emily Aijun Liu
Andrzej Robert Daniewski
William Harris
Marek Michal Kabat
Christophe Michoud
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8580001A1 publication Critical patent/PA8580001A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REVELAN NUEVOS COMPUESTOS PIRIMIDO DE LA FORMULA I QUE SON INHIBIDORES SELECTIVOS DE AMBAS KDR Y FGFR QUINASAS Y SON SELECTIVAS CONTRA LCK. ESTOS COMPUESTOS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES SON AGENTES ANTIPROLIFERATIVOS UTILES EN EL TRATAMIENTO O CONTROL DE TUMORES SOLIDOS, EN PARTICULAR TUMORES DE MAMA, COLON, PULMON Y PROSTATA. TAMBIEN SE REVELAN COMPOSICIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS Y UN PROCESO PARA SU PREPARACION.
PA20038580001A 2002-08-14 2003-08-11 Compuestos pirimido que tienen actividad antiproliferativa PA8580001A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40351902P 2002-08-14 2002-08-14

Publications (1)

Publication Number Publication Date
PA8580001A1 true PA8580001A1 (es) 2004-03-10

Family

ID=31946709

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038580001A PA8580001A1 (es) 2002-08-14 2003-08-11 Compuestos pirimido que tienen actividad antiproliferativa

Country Status (19)

Country Link
US (1) US7084270B2 (es)
EP (1) EP1556384B1 (es)
JP (1) JP2005538141A (es)
KR (1) KR20070087687A (es)
CN (1) CN1323080C (es)
AR (1) AR040971A1 (es)
AT (1) ATE386743T1 (es)
AU (1) AU2003255389A1 (es)
BR (1) BR0313732A (es)
CA (1) CA2494127A1 (es)
DE (1) DE60319255T2 (es)
ES (1) ES2300644T3 (es)
MX (1) MXPA05001629A (es)
PA (1) PA8580001A1 (es)
PL (1) PL375588A1 (es)
RU (1) RU2336275C2 (es)
TW (1) TW200407326A (es)
UY (1) UY27937A1 (es)
WO (1) WO2004018472A2 (es)

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DE602005013248D1 (de) 2004-08-31 2009-04-23 Hoffmann La Roche Amidderivate von 3-phenyldihydropyrimidoä4,5-düpyrimidinonen, deren herstellung und verwendung als pharmazeutische mittel
US20120189641A1 (en) 2009-02-25 2012-07-26 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
EP2401614A1 (en) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
US9896730B2 (en) 2011-04-25 2018-02-20 OSI Pharmaceuticals, LLC Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
CN102816162B (zh) * 2011-06-10 2016-04-27 中国科学院广州生物医药与健康研究院 嘧啶并嘧啶酮类化合物及其药用组合物和应用
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
CN107652289B (zh) 2012-06-13 2020-07-21 因塞特控股公司 作为fgfr抑制剂的取代的三环化合物
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
CN104968664A (zh) * 2012-12-12 2015-10-07 山东亨利医药科技有限责任公司 作为酪氨酸激酶抑制剂的并环化合物
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
EA036160B1 (ru) 2013-03-15 2020-10-08 Селджен Кар Ллс Гетероарильные соединения и их применение
KR102350704B1 (ko) 2013-03-15 2022-01-13 셀젠 카르 엘엘씨 헤테로아릴 화합물 및 이의 용도
AR095464A1 (es) 2013-03-15 2015-10-21 Celgene Avilomics Res Inc Compuestos de heteroarilo y usos de los mismos
JP6449244B2 (ja) 2013-04-19 2019-01-09 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｆｇｆｒ抑制剤としての二環式複素環
CN104418860B (zh) * 2013-08-20 2016-09-07 中国科学院广州生物医药与健康研究院 嘧啶并杂环类化合物及其药用组合物和应用
US10287268B2 (en) 2014-07-21 2019-05-14 Dana-Farber Cancer Institute, Inc. Imidazolyl kinase inhibitors and uses thereof
DK3172213T3 (da) 2014-07-21 2021-12-13 Dana Farber Cancer Inst Inc Makrocykliske kinasehæmmere og anvendelser deraf
WO2016023014A2 (en) 2014-08-08 2016-02-11 Dana-Farber Cancer Institute, Inc. Uses of salt-inducible kinase (sik) inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134320A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US10954242B2 (en) 2016-07-05 2021-03-23 The Broad Institute, Inc. Bicyclic urea kinase inhibitors and uses thereof
US11241435B2 (en) 2016-09-16 2022-02-08 The General Hospital Corporation Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis
BR112019017741A2 (pt) * 2017-02-28 2020-04-07 Dana Farber Cancer Inst Inc usos de pirimidopirimidinonas como inibidores de sik
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
SG11202010882XA (en) 2018-05-04 2020-11-27 Incyte Corp Salts of an fgfr inhibitor
DK3788047T3 (da) 2018-05-04 2024-09-16 Incyte Corp Faste former af en FGFR-inhibitor og fremgangsmåder til fremstilling deraf
CN113474347A (zh) * 2018-12-27 2021-10-01 法国施维雅药厂 Mat2a的aza杂双环抑制剂和用于治疗癌症的方法
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
MX2022004513A (es) 2019-10-14 2022-07-19 Incyte Corp Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr).
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
BR112022010664A2 (pt) 2019-12-04 2022-08-16 Incyte Corp Derivados de um inibidor de fgfr
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4323405A1 (en) 2021-04-12 2024-02-21 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
CA3220274A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors

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BR9911590A (pt) 1998-05-26 2001-02-13 Warner Lambert Co Pirimidinas bicìclicas e 3,4-diidropirimidinas bicìclicas como inibidores da proliferação celular
CZ20011394A3 (cs) 1998-10-23 2001-12-12 F. Hoffmann-La Roche Ag Derivát bicyklických, dusík obsahujících heterocyklických sloučenin, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje
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JP3961830B2 (ja) 1999-10-21 2007-08-22 エフ．ホフマン−ラ ロシュ アーゲー ｐ３８プロテインキナーゼのインヒビターとしてのヘテロアルキルアミノ置換二環式窒素複素環
AR030053A1 (es) 2000-03-02 2003-08-13 Smithkline Beecham Corp 1h-pirimido [4,5-d] pirimidin-2-onas y sales, composiciones farmaceuticas, uso para la fabricacion de un medicamento y procedimiento para producirlas
CN1275964C (zh) 2000-08-31 2006-09-20 霍夫曼-拉罗奇有限公司 作为细胞增殖抑制剂的7－氧代吡啶并嘧啶
PA8577501A1 (es) 2002-07-25 2004-02-07 Warner Lambert Co Inhibidores de quinasas

Also Published As

Publication number Publication date
BR0313732A (pt) 2005-09-27
ES2300644T3 (es) 2008-06-16
ATE386743T1 (de) 2008-03-15
AU2003255389A1 (en) 2004-03-11
PL375588A1 (en) 2005-11-28
WO2004018472A3 (en) 2004-04-29
CA2494127A1 (en) 2004-03-04
TW200407326A (en) 2004-05-16
DE60319255T2 (de) 2009-03-05
US20040038995A1 (en) 2004-02-26
JP2005538141A (ja) 2005-12-15
RU2336275C2 (ru) 2008-10-20
CN1675214A (zh) 2005-09-28
WO2004018472A2 (en) 2004-03-04
DE60319255D1 (de) 2008-04-03
UY27937A1 (es) 2004-02-27
MXPA05001629A (es) 2005-04-25
US7084270B2 (en) 2006-08-01
EP1556384A2 (en) 2005-07-27
CN1323080C (zh) 2007-06-27
KR20070087687A (ko) 2007-08-28
RU2005107314A (ru) 2005-11-20
EP1556384B1 (en) 2008-02-20
AR040971A1 (es) 2005-04-27

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