US7459554B2
(en)
*
|
2003-10-15 |
2008-12-02 |
Osi Pharmaceuticals, Inc. |
Imidazopyrazine tyrosine kinase inhibitors
|
BRPI0416656A
(pt)
|
2003-11-17 |
2007-01-16 |
Pfizer Prod Inc |
compostos de pirrolopirimidina úteis no tratamento do cáncer
|
TW201134828A
(en)
*
|
2004-04-02 |
2011-10-16 |
Osi Pharm Inc |
6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
|
BRPI0511512A
(pt)
*
|
2004-05-27 |
2007-12-26 |
Pfizer Prod Inc |
derivados pirrolpirimidina úteis no tratamento do cáncer
|
TW200613306A
(en)
*
|
2004-07-20 |
2006-05-01 |
Osi Pharm Inc |
Imidazotriazines as protein kinase inhibitors
|
WO2006076592A1
(en)
|
2005-01-14 |
2006-07-20 |
Cgi Pharmaceuticals, Inc. |
1,3 substituted diaryl ureas as modulators of kinase activity
|
US20070287719A1
(en)
*
|
2005-03-11 |
2007-12-13 |
Pfizer Inc |
Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea
|
US7777040B2
(en)
|
2005-05-03 |
2010-08-17 |
Cgi Pharmaceuticals, Inc. |
Certain substituted ureas, as modulators of kinase activity
|
US7795248B2
(en)
*
|
2005-05-18 |
2010-09-14 |
Abbott Laboratories, Inc. |
Substituted 7,8-dihydro-1H-pyrimido[4,5-B][1,4]diazepin-4-amines are novel kinase inhibitors
|
DE102005037499A1
(de)
*
|
2005-08-09 |
2007-02-15 |
Merck Patent Gmbh |
Pyrazolderivate
|
EP1928843A1
(en)
*
|
2005-08-22 |
2008-06-11 |
Amgen, Inc |
Bis-aryl urea compounds for the treatment of protein kinase-mediated diseaes
|
EP1940844B1
(en)
*
|
2005-10-28 |
2009-09-30 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
EP2385053B1
(en)
*
|
2005-11-17 |
2013-10-02 |
OSI Pharmaceuticals, Inc. |
Intermediates for the preparation of fused bicyclic mTOR inhibitors
|
US20070135387A1
(en)
*
|
2005-12-08 |
2007-06-14 |
Michaelides Michael R |
Inhibitors of protein kinases
|
WO2007066189A2
(en)
*
|
2005-12-09 |
2007-06-14 |
Pfizer Products Inc. |
Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-urea
|
US20080299113A1
(en)
*
|
2005-12-19 |
2008-12-04 |
Arnold Lee D |
Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents
|
US8575164B2
(en)
*
|
2005-12-19 |
2013-11-05 |
OSI Pharmaceuticals, LLC |
Combination cancer therapy
|
EP1973917B1
(en)
*
|
2005-12-29 |
2015-06-10 |
AbbVie Inc. |
Protein kinase inhibitors
|
NZ577127A
(en)
|
2006-11-22 |
2012-03-30 |
Incyte Corp |
Imidazotriazines and imidazopyrimidines as kinase inhibitors
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
WO2008076143A1
(en)
*
|
2006-12-18 |
2008-06-26 |
Osi Pharmaceuticals, Inc. |
Combination of igfr inhibitor and anti-cancer agent
|
MX2010000617A
(es)
|
2007-07-17 |
2010-05-17 |
Plexxikon Inc |
Compuestos y metodos para modulacion de cinasa, e indicaciones de estos.
|
GB2467670B
(en)
|
2007-10-04 |
2012-08-01 |
Intellikine Inc |
Chemical entities and therapeutic uses thereof
|
US20100331297A1
(en)
*
|
2007-11-07 |
2010-12-30 |
Foldrx Pharmaceuticals, Inc. |
Modulation of protein trafficking
|
JP2011510018A
(ja)
*
|
2008-01-18 |
2011-03-31 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
癌治療のためのイミダゾピラジノール誘導体
|
EP2252293B1
(en)
|
2008-03-14 |
2018-06-27 |
Intellikine, LLC |
Kinase inhibitors and methods of use
|
US8993580B2
(en)
|
2008-03-14 |
2015-03-31 |
Intellikine Llc |
Benzothiazole kinase inhibitors and methods of use
|
JP2011520970A
(ja)
*
|
2008-05-19 |
2011-07-21 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
置換されたイミダゾピラジン類およびイミダゾトリアジン類
|
US8158636B2
(en)
|
2008-05-19 |
2012-04-17 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
PE20091846A1
(es)
*
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
EP2313411A1
(en)
*
|
2008-06-10 |
2011-04-27 |
Plexxikon, Inc. |
5h-pyrr0l0 [2,3-b]pyrazine derivatives for kinase modulation, and indications therefor
|
US8110576B2
(en)
*
|
2008-06-10 |
2012-02-07 |
Plexxikon Inc. |
Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications
|
WO2009158432A2
(en)
|
2008-06-27 |
2009-12-30 |
Amgen Inc. |
Ang-2 inhibition to treat multiple sclerosis
|
CA2730106A1
(en)
|
2008-07-08 |
2010-01-14 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
US8697709B2
(en)
*
|
2008-10-16 |
2014-04-15 |
The Regents Of The University Of California |
Fused ring heteroaryl kinase inhibitors
|
US8476431B2
(en)
*
|
2008-11-03 |
2013-07-02 |
Itellikine LLC |
Benzoxazole kinase inhibitors and methods of use
|
JP2012520893A
(ja)
|
2009-03-18 |
2012-09-10 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
Egfr阻害薬及びigf−1r阻害剤の投与を含む組み合わせ癌治療
|
SG173178A1
(en)
|
2009-04-03 |
2011-09-29 |
Hoffmann La Roche |
Propane- i-sulfonic acid {3- [5- (4 -chloro-phenyl) -1h-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
|
KR20120020099A
(ko)
|
2009-04-20 |
2012-03-07 |
오에스아이 파마슈티컬스, 엘엘씨 |
C-피라진-메틸아민의 제조
|
WO2010129740A1
(en)
*
|
2009-05-07 |
2010-11-11 |
Osi Pharmaceuticals, Inc. |
Use of osi-906 for treating adrenocortical carcinoma
|
US8329724B2
(en)
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
TR201900259T4
(tr)
|
2009-08-17 |
2019-02-21 |
Intellikine Llc |
Heterosiklik Bileşikler Ve Bunların Kullanımları
|
BR112012003462A2
(pt)
|
2009-08-24 |
2016-02-23 |
Ascepion Pharmaceuticals Inc |
"composto, composição farmacêutica, e, método para tratar um paciente tendo uma condição mediada pela proteína quinase."
|
BR112012012156A2
(pt)
|
2009-11-06 |
2015-09-08 |
Plexxikon Inc |
compostos e métodos para modulação de cinase, e indicações para esta
|
CN105906631A
(zh)
|
2009-11-18 |
2016-08-31 |
普莱希科公司 |
用于激酶调节的化合物和方法及其适应症
|
US20110130711A1
(en)
*
|
2009-11-19 |
2011-06-02 |
Follica, Inc. |
Hair growth treatment
|
JP2013516420A
(ja)
|
2009-12-30 |
2013-05-13 |
アークル インコーポレイテッド |
置換されたピロロ−アミノピリミジン化合物
|
WO2011153553A2
(en)
*
|
2010-06-04 |
2011-12-08 |
The Regents Of The University Of California |
Methods and compositions for kinase inhibition
|
US10420665B2
(en)
|
2010-06-13 |
2019-09-24 |
W. L. Gore & Associates, Inc. |
Intragastric device for treating obesity
|
US9526648B2
(en)
|
2010-06-13 |
2016-12-27 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
US8628554B2
(en)
|
2010-06-13 |
2014-01-14 |
Virender K. Sharma |
Intragastric device for treating obesity
|
US10010439B2
(en)
|
2010-06-13 |
2018-07-03 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
JP6063870B2
(ja)
*
|
2010-11-08 |
2017-01-18 |
ライセラ・コーポレイション |
RORγ活性の阻害用のN−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療
|
WO2012088266A2
(en)
|
2010-12-22 |
2012-06-28 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
|
CA2826123C
(en)
|
2011-02-07 |
2016-08-09 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
JP6130305B2
(ja)
|
2011-02-23 |
2017-05-17 |
インテリカイン, エルエルシー |
キナーゼ阻害剤の組み合わせおよびそれらの使用
|
WO2012129145A1
(en)
|
2011-03-18 |
2012-09-27 |
OSI Pharmaceuticals, LLC |
Nscle combination therapy
|
GEP20156417B
(en)
|
2011-04-05 |
2015-12-25 |
Pfizer Ltd |
Pyrrolo [2,3-d] pyrimidine derivatives as inhibitors of tropomyosin-related kinases
|
KR20140048968A
(ko)
*
|
2011-07-13 |
2014-04-24 |
파마시클릭스, 인코포레이티드 |
브루톤형 티로신 키나제의 억제제
|
US9295671B2
(en)
|
2011-08-26 |
2016-03-29 |
Neupharma, Inc. |
Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer
|
MX370814B
(es)
|
2011-09-02 |
2020-01-08 |
Univ California |
Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
|
CN108794411B
(zh)
|
2011-09-14 |
2022-06-07 |
润新生物公司 |
某些化学实体、组合物及方法
|
EA201491427A1
(ru)
*
|
2012-01-25 |
2015-01-30 |
Байер Фарма Акциенгезельшафт |
Замещенные фенилимидазопиразолы и их применение
|
EP2806874B1
(en)
|
2012-01-25 |
2017-11-15 |
Neupharma, Inc. |
Quinoxaline-oxy-phenyl derivatives as kinase inhibitors
|
RU2014149136A
(ru)
|
2012-05-08 |
2016-07-10 |
Мерк Шарп И Доум Корп. |
ТЕТРАГИДРОНАФТИРИДИНОВЫЕ И РОДСТВЕННЫЕ БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORγ АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ
|
US9394315B2
(en)
|
2012-05-08 |
2016-07-19 |
Lycera Corporation |
Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
CN107652289B
(zh)
|
2012-06-13 |
2020-07-21 |
因塞特控股公司 |
作为fgfr抑制剂的取代的三环化合物
|
WO2014026125A1
(en)
|
2012-08-10 |
2014-02-13 |
Incyte Corporation |
Pyrazine derivatives as fgfr inhibitors
|
CN104812389B
(zh)
|
2012-09-24 |
2020-07-17 |
润新生物公司 |
某些化学实体、组合物及方法
|
BR112015006828A8
(pt)
|
2012-09-26 |
2019-09-17 |
Univ California |
composto, ou um sal farmaceuticamente aceitável do mesmo; composição farmacêutica; uso do composto; e método para modular a atividade de uma proteína ire1
|
US20150218172A1
(en)
|
2012-10-04 |
2015-08-06 |
Pfizer Limited |
Pyrrolo[2,3-D]Pyrimidine Tropomyosin-Related Kinase Inhibitors
|
EP2903986A1
(en)
|
2012-10-04 |
2015-08-12 |
Pfizer Limited |
Tropomyosin-related kinase inhibitors
|
JP2015531395A
(ja)
|
2012-10-04 |
2015-11-02 |
ファイザー・リミテッドPfizer Limited |
ピロロ[3,2−c]ピリジントロポミオシン関連キナーゼ阻害剤
|
WO2014075077A1
(en)
|
2012-11-12 |
2014-05-15 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
CA2907726A1
(en)
|
2013-03-22 |
2014-09-25 |
Millennium Pharmaceuticals, Inc. |
Combination of catalytic mtorc1/2 inhibitors and selective inhibitors of aurora a kinase
|
SI2986610T1
(en)
|
2013-04-19 |
2018-04-30 |
Incyte Holdings Corporation |
Bicyclic heterocycles as inhibitors of FGFR
|
US9663502B2
(en)
|
2013-12-20 |
2017-05-30 |
Lycera Corporation |
2-Acylamidomethyl and sulfonylamidomethyl benzoxazine carbamates for inhibition of RORgamma activity and the treatment of disease
|
US9783511B2
(en)
|
2013-12-20 |
2017-10-10 |
Lycera Corporation |
Carbamate benzoxazine propionic acids and acid derivatives for modulation of RORgamma activity and the treatment of disease
|
WO2015092610A1
(en)
|
2013-12-20 |
2015-06-25 |
Pfizer Limited |
N-acylpiperidine ether tropomyosin-related kinase inhibitors
|
US9809561B2
(en)
|
2013-12-20 |
2017-11-07 |
Merck Sharp & Dohme Corp. |
Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
|
JP2017507950A
(ja)
|
2014-02-27 |
2017-03-23 |
リセラ・コーポレイションLycera Corporation |
レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法
|
WO2015159175A1
(en)
|
2014-04-15 |
2015-10-22 |
Pfizer Inc. |
Tropomyosin-related kinase inhibitors containing both a 1h-pyrazole and a pyrimidine moiety
|
EP3209641A4
(en)
|
2014-05-05 |
2018-06-06 |
Lycera Corporation |
Benzenesulfonamido and related compounds for use as agonists of ror and the treatement of disease
|
EP3140291A4
(en)
|
2014-05-05 |
2018-01-10 |
Lycera Corporation |
Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease
|
WO2015170218A1
(en)
|
2014-05-07 |
2015-11-12 |
Pfizer Inc. |
Tropomyosin-related kinase inhibitors
|
WO2016009296A1
(en)
|
2014-07-16 |
2016-01-21 |
Pfizer Inc. |
N-acylpiperidine ether tropomyosin-related kinase inhibitors
|
WO2016020784A1
(en)
|
2014-08-05 |
2016-02-11 |
Pfizer Inc. |
N-acylpyrrolidine ether tropomyosin-related kinase inhibitors
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
KR102562866B1
(ko)
|
2014-11-14 |
2023-08-04 |
네르비아노 메디칼 사이언시스 에스.알.엘. |
단백질 키나아제 억제제로서의 6-아미노-7-바이사이클로-7-데아자-퓨린 유도체
|
WO2016130818A1
(en)
|
2015-02-11 |
2016-08-18 |
Merck Sharp & Dohme Corp. |
SUBSTITUTED PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
WO2016134294A1
(en)
|
2015-02-20 |
2016-08-25 |
Incyte Corporation |
Bicyclic heterocycles as fgfr4 inhibitors
|
AU2016219822B2
(en)
|
2015-02-20 |
2020-07-09 |
Incyte Holdings Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
JP6793401B2
(ja)
*
|
2015-03-11 |
2020-12-02 |
国立研究開発法人理化学研究所 |
難治性白血病治療薬
|
WO2016179343A1
(en)
|
2015-05-05 |
2016-11-10 |
Lycera Corporation |
DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE
|
WO2016201225A1
(en)
|
2015-06-11 |
2016-12-15 |
Lycera Corporation |
Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of rory and the treatment of disease
|
MA41559A
(fr)
|
2015-09-08 |
2017-12-26 |
Taiho Pharmaceutical Co Ltd |
Composé de pyrimidine condensé ou un sel de celui-ci
|
AU2016344118A1
(en)
|
2015-10-27 |
2018-05-10 |
Merck Sharp & Dohme Corp. |
Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof
|
AU2016344111A1
(en)
|
2015-10-27 |
2018-05-10 |
Merck Sharp & Dohme Corp. |
Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof
|
EP3368539B1
(en)
|
2015-10-27 |
2020-12-02 |
Merck Sharp & Dohme Corp. |
Substituted indazole compounds as ror gamma t inhibitors and uses thereof
|
EP3383390A4
(en)
*
|
2015-12-02 |
2019-11-20 |
Astraea Therapeutics, LLC |
PIPERIDINYL COMPOUNDS FOR NOCICEPTIN RECEPTOR
|
US10112924B2
(en)
|
2015-12-02 |
2018-10-30 |
Astraea Therapeutics, Inc. |
Piperdinyl nociceptin receptor compounds
|
US9630968B1
(en)
|
2015-12-23 |
2017-04-25 |
Arqule, Inc. |
Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
|
WO2017133669A1
(en)
*
|
2016-02-05 |
2017-08-10 |
Savira Pharmaceuticals Gmbh |
5, 7-diazaindole and 5, 7-diazaindazole derivatives and their use in the treatment, amelioration or prevention of influenza
|
RU2770727C2
(ru)
|
2016-02-23 |
2022-04-21 |
Тайхо Фармасьютикал Ко., Лтд. |
Новое конденсированное пиримидиновое соединение или его соль
|
US10779980B2
(en)
|
2016-04-27 |
2020-09-22 |
Synerz Medical, Inc. |
Intragastric device for treating obesity
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
CN110461849B
(zh)
*
|
2017-06-19 |
2020-09-01 |
上海和誉生物医药科技有限公司 |
一种csf1r抑制剂及其制备方法和应用
|
WO2019036001A1
(en)
*
|
2017-08-17 |
2019-02-21 |
Vyera Pharmaceuticals, LLC |
CDPK1 INHIBITOR, COMPOSITIONS AND RELATED METHODS
|
JP2021523121A
(ja)
|
2018-05-04 |
2021-09-02 |
インサイト・コーポレイションIncyte Corporation |
Fgfr阻害剤の固体形態及びその調製プロセス
|
JP2021523118A
(ja)
|
2018-05-04 |
2021-09-02 |
インサイト・コーポレイションIncyte Corporation |
Fgfr阻害剤の塩
|
US11628162B2
(en)
|
2019-03-08 |
2023-04-18 |
Incyte Corporation |
Methods of treating cancer with an FGFR inhibitor
|
US11591329B2
(en)
|
2019-07-09 |
2023-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
JOP20220083A1
(ar)
|
2019-10-14 |
2023-01-30 |
Incyte Corp |
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