OA12886A - Bicyclic piperidine derivatives as antagonists of the CCR1 chemokine receptor. - Google Patents

Bicyclic piperidine derivatives as antagonists of the CCR1 chemokine receptor. Download PDF

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Publication number
OA12886A
OA12886A OA1200500011A OA1200500011A OA12886A OA 12886 A OA12886 A OA 12886A OA 1200500011 A OA1200500011 A OA 1200500011A OA 1200500011 A OA1200500011 A OA 1200500011A OA 12886 A OA12886 A OA 12886A
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OA
OAPI
Prior art keywords
phenoxy
aza
fluoro
bicyclo
oct
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Application number
OA1200500011A
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English (en)
Inventor
Laura Cook Blumberg
Matthew Frank Brown
Matthew Merrill Hayward
Christopher Stanley Poss
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Pfizer Prod Inc
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Publication of OA12886A publication Critical patent/OA12886A/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
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    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
OA1200500011A 2002-07-18 2005-07-07 Bicyclic piperidine derivatives as antagonists of the CCR1 chemokine receptor. OA12886A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39726302P 2002-07-18 2002-07-18

Publications (1)

Publication Number Publication Date
OA12886A true OA12886A (en) 2006-09-15

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OA1200500011A OA12886A (en) 2002-07-18 2005-07-07 Bicyclic piperidine derivatives as antagonists of the CCR1 chemokine receptor.

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US (1) US20040063688A1 (ko)
EP (1) EP1525201A1 (ko)
JP (1) JP2005533845A (ko)
KR (1) KR20050028036A (ko)
CN (1) CN1668614A (ko)
AP (1) AP2005003196A0 (ko)
AR (1) AR040586A1 (ko)
AU (1) AU2003281527A1 (ko)
BR (1) BR0312699A (ko)
CA (1) CA2492110A1 (ko)
EA (1) EA200500033A1 (ko)
EC (1) ECSP055548A (ko)
GT (1) GT200300147A (ko)
IL (1) IL166075A0 (ko)
IS (1) IS7615A (ko)
MA (1) MA27327A1 (ko)
MX (1) MXPA05000757A (ko)
OA (1) OA12886A (ko)
PA (1) PA8577401A1 (ko)
PE (1) PE20040668A1 (ko)
TN (1) TNSN05013A1 (ko)
TW (1) TW200401639A (ko)
UY (1) UY27896A1 (ko)
WO (1) WO2004009588A1 (ko)

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UA82517C2 (uk) * 2003-06-24 2008-04-25 Ньюросерч А/С Нові похідні 8-аза-біцикло[3.2.1]октану та їх застосування як інгібіторів ресорбції моноамінових медіаторів
US7230022B2 (en) 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7288563B2 (en) 2004-02-19 2007-10-30 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7479496B2 (en) 2004-02-19 2009-01-20 Bristol-Myers Squibb Company Substituted spiro azabicyclics as modulators of chemokine receptor activity
GB0409236D0 (en) * 2004-04-26 2004-05-26 Novartis Ag Organic compounds
WO2006075004A2 (en) 2005-01-13 2006-07-20 Neurosearch A/S 3, 8 - substituted 8-aza-bicyclo[3.2.1] octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
ES2277745B1 (es) * 2005-06-14 2008-06-01 Laboratorios Almirall S.A. Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1.
US20070105874A1 (en) * 2005-09-23 2007-05-10 Conforma Therapeutics Corporation Anti-Tumor Methods Using Multi Drug Resistance Independent Synthetic HSP90 Inhibitors
ITFI20120062A1 (it) * 2012-03-21 2013-09-22 Minerva Patents S A Componenti per il trattamento di malattie correlate a ischemia-riperfusione.
AU2014291711B2 (en) * 2013-07-18 2017-02-02 Novartis Ag Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core
CN104122392B (zh) * 2014-06-24 2016-05-25 上海交通大学医学院附属瑞金医院 检测ccl15趋化因子的试剂在制备筛选甲状腺滤泡癌试剂中的应用

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AR028947A1 (es) * 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
PA8575901A1 (es) * 2002-07-18 2004-07-20 Pfizer Prod Inc Derivados de piperidina novedosos

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PE20040668A1 (es) 2004-09-25
IS7615A (is) 2004-12-23
AP2005003196A0 (en) 2005-03-31
BR0312699A (pt) 2005-04-26
GT200300147A (es) 2004-04-19
AU2003281527A1 (en) 2004-02-09
TW200401639A (en) 2004-02-01
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ECSP055548A (es) 2005-03-10
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MA27327A1 (fr) 2005-05-02
UY27896A1 (es) 2004-02-27
US20040063688A1 (en) 2004-04-01
TNSN05013A1 (fr) 2007-05-14
KR20050028036A (ko) 2005-03-21
MXPA05000757A (es) 2005-04-19
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AR040586A1 (es) 2005-04-13

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