ECSP055548A - Derivados de piperidina biciclicos como antagonistas del receptor quimioquinas ccr1 - Google Patents
Derivados de piperidina biciclicos como antagonistas del receptor quimioquinas ccr1Info
- Publication number
- ECSP055548A ECSP055548A EC2005005548A ECSP055548A ECSP055548A EC SP055548 A ECSP055548 A EC SP055548A EC 2005005548 A EC2005005548 A EC 2005005548A EC SP055548 A ECSP055548 A EC SP055548A EC SP055548 A ECSP055548 A EC SP055548A
- Authority
- EC
- Ecuador
- Prior art keywords
- ccr1
- chemioquines
- antagonists
- bicycle
- receiver
- Prior art date
Links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
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- Biotechnology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
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- Heart & Thoracic Surgery (AREA)
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Abstract
Compuesto de fórmula (ver gráfico) en la que a,b,c, R1, R2, R3, R4, R5,R6, Q, W, Y, y Z son como se definieron anteriormente, útiles como potentes y selectivos inhibidores de la unión de MIP-1 (CCL3) a su receptor CCR1 hallado en células (preferiblemente leucocitos y linfocitos) inflamatorias e inmunomoduladoras.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39726302P | 2002-07-18 | 2002-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP055548A true ECSP055548A (es) | 2005-03-10 |
Family
ID=30771023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2005005548A ECSP055548A (es) | 2002-07-18 | 2005-01-18 | Derivados de piperidina biciclicos como antagonistas del receptor quimioquinas ccr1 |
Country Status (24)
Country | Link |
---|---|
US (1) | US20040063688A1 (es) |
EP (1) | EP1525201A1 (es) |
JP (1) | JP2005533845A (es) |
KR (1) | KR20050028036A (es) |
CN (1) | CN1668614A (es) |
AP (1) | AP2005003196A0 (es) |
AR (1) | AR040586A1 (es) |
AU (1) | AU2003281527A1 (es) |
BR (1) | BR0312699A (es) |
CA (1) | CA2492110A1 (es) |
EA (1) | EA200500033A1 (es) |
EC (1) | ECSP055548A (es) |
GT (1) | GT200300147A (es) |
IL (1) | IL166075A0 (es) |
IS (1) | IS7615A (es) |
MA (1) | MA27327A1 (es) |
MX (1) | MXPA05000757A (es) |
OA (1) | OA12886A (es) |
PA (1) | PA8577401A1 (es) |
PE (1) | PE20040668A1 (es) |
TN (1) | TNSN05013A1 (es) |
TW (1) | TW200401639A (es) |
UY (1) | UY27896A1 (es) |
WO (1) | WO2004009588A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009513491A (ja) * | 2003-06-24 | 2009-04-02 | ノイロサーチ アクティーゼルスカブ | 新規な8−アザ−ビシクロ[3.2.1]オクタン誘導体、及びモノアミン神経伝達物質の再取り込み阻害剤としてのその使用 |
US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
GB0409236D0 (en) * | 2004-04-26 | 2004-05-26 | Novartis Ag | Organic compounds |
EP1838705A2 (en) | 2005-01-13 | 2007-10-03 | Neurosearch A/S | 3,8-substituted 8-aza-bicyclo [3.2.1] octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
ES2277745B1 (es) * | 2005-06-14 | 2008-06-01 | Laboratorios Almirall S.A. | Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1. |
EP1937258A2 (en) * | 2005-09-23 | 2008-07-02 | Conforma Therapeutics Corporation | Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors |
ITFI20120062A1 (it) * | 2012-03-21 | 2013-09-22 | Minerva Patents S A | Componenti per il trattamento di malattie correlate a ischemia-riperfusione. |
AU2014291711B2 (en) | 2013-07-18 | 2017-02-02 | Novartis Ag | Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core |
CN104122392B (zh) * | 2014-06-24 | 2016-05-25 | 上海交通大学医学院附属瑞金医院 | 检测ccl15趋化因子的试剂在制备筛选甲状腺滤泡癌试剂中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR028947A1 (es) * | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
PA8575901A1 (es) * | 2002-07-18 | 2004-07-20 | Pfizer Prod Inc | Derivados de piperidina novedosos |
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2003
- 2003-07-07 AP AP2005003196A patent/AP2005003196A0/xx unknown
- 2003-07-07 EA EA200500033A patent/EA200500033A1/ru unknown
- 2003-07-07 JP JP2004522638A patent/JP2005533845A/ja active Pending
- 2003-07-07 KR KR1020057000875A patent/KR20050028036A/ko not_active Application Discontinuation
- 2003-07-07 AU AU2003281527A patent/AU2003281527A1/en not_active Abandoned
- 2003-07-07 WO PCT/IB2003/003155 patent/WO2004009588A1/en not_active Application Discontinuation
- 2003-07-07 CN CNA038170051A patent/CN1668614A/zh active Pending
- 2003-07-07 MX MXPA05000757A patent/MXPA05000757A/es not_active Application Discontinuation
- 2003-07-07 EP EP03741007A patent/EP1525201A1/en not_active Withdrawn
- 2003-07-07 CA CA002492110A patent/CA2492110A1/en not_active Abandoned
- 2003-07-07 BR BR0312699-4A patent/BR0312699A/pt not_active Application Discontinuation
- 2003-07-08 US US10/616,843 patent/US20040063688A1/en not_active Abandoned
- 2003-07-11 PA PA20038577401A patent/PA8577401A1/es unknown
- 2003-07-16 UY UY27896A patent/UY27896A1/es not_active Application Discontinuation
- 2003-07-16 AR AR20030102558A patent/AR040586A1/es unknown
- 2003-07-16 PE PE2003000712A patent/PE20040668A1/es not_active Application Discontinuation
- 2003-07-17 GT GT200300147A patent/GT200300147A/es unknown
- 2003-07-17 TW TW092119524A patent/TW200401639A/zh unknown
-
2004
- 2004-12-23 IS IS7615A patent/IS7615A/is unknown
- 2004-12-30 IL IL16607504A patent/IL166075A0/xx unknown
-
2005
- 2005-01-18 MA MA28050A patent/MA27327A1/fr unknown
- 2005-01-18 EC EC2005005548A patent/ECSP055548A/es unknown
- 2005-01-18 TN TNP2005000013A patent/TNSN05013A1/fr unknown
- 2005-07-07 OA OA1200500011A patent/OA12886A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AP2005003196A0 (en) | 2005-03-31 |
OA12886A (en) | 2006-09-15 |
TNSN05013A1 (fr) | 2007-05-14 |
TW200401639A (en) | 2004-02-01 |
PE20040668A1 (es) | 2004-09-25 |
CA2492110A1 (en) | 2004-01-29 |
JP2005533845A (ja) | 2005-11-10 |
IS7615A (is) | 2004-12-23 |
MA27327A1 (fr) | 2005-05-02 |
MXPA05000757A (es) | 2005-04-19 |
WO2004009588A1 (en) | 2004-01-29 |
AR040586A1 (es) | 2005-04-13 |
AU2003281527A1 (en) | 2004-02-09 |
GT200300147A (es) | 2004-04-19 |
IL166075A0 (en) | 2006-01-15 |
US20040063688A1 (en) | 2004-04-01 |
PA8577401A1 (es) | 2004-03-10 |
EA200500033A1 (ru) | 2005-06-30 |
UY27896A1 (es) | 2004-02-27 |
KR20050028036A (ko) | 2005-03-21 |
CN1668614A (zh) | 2005-09-14 |
BR0312699A (pt) | 2005-04-26 |
EP1525201A1 (en) | 2005-04-27 |
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