ECSP055547A - Derivados de piperidina novedosos - Google Patents
Derivados de piperidina novedososInfo
- Publication number
- ECSP055547A ECSP055547A EC2005005547A ECSP055547A ECSP055547A EC SP055547 A ECSP055547 A EC SP055547A EC 2005005547 A EC2005005547 A EC 2005005547A EC SP055547 A ECSP055547 A EC SP055547A EC SP055547 A ECSP055547 A EC SP055547A
- Authority
- EC
- Ecuador
- Prior art keywords
- piperidine derivatives
- new piperidine
- new
- ccl3
- mip
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula. en el que a, b, c, R1, R2, R3, R4, R5, R6, R7, Q, W, Y y Z son como se define anteriormente, útiles como inhibidores potentes y selectivos de la unión de MIP-1a (CCL3) a su receptor CCR1 que se encuentra en las células inflamatorias e inmunomoduladoras (preferiblemente leucocitos y linfocitos).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39710802P | 2002-07-18 | 2002-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP055547A true ECSP055547A (es) | 2005-03-10 |
Family
ID=30770997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2005005547A ECSP055547A (es) | 2002-07-18 | 2005-01-18 | Derivados de piperidina novedosos |
Country Status (24)
Country | Link |
---|---|
US (1) | US20040063759A1 (es) |
EP (1) | EP1534677A1 (es) |
JP (1) | JP2005537279A (es) |
KR (1) | KR20050021497A (es) |
CN (1) | CN1668592A (es) |
AP (1) | AP2005003200A0 (es) |
AR (1) | AR040583A1 (es) |
AU (1) | AU2003242941A1 (es) |
BR (1) | BR0312946A (es) |
CA (1) | CA2492651A1 (es) |
EC (1) | ECSP055547A (es) |
HN (1) | HN2003000222A (es) |
IL (1) | IL166010A0 (es) |
IS (1) | IS7614A (es) |
MA (1) | MA27326A1 (es) |
MX (1) | MXPA05000380A (es) |
OA (1) | OA12885A (es) |
PA (1) | PA8575901A1 (es) |
PE (1) | PE20040666A1 (es) |
TN (1) | TNSN05014A1 (es) |
TW (1) | TW200402416A (es) |
UY (1) | UY27897A1 (es) |
WO (1) | WO2004009550A1 (es) |
ZA (1) | ZA200500067B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7399790B2 (en) | 2001-02-28 | 2008-07-15 | Konowalchuk Thomas W | Virucidal compositions |
JP4723242B2 (ja) | 2002-06-12 | 2011-07-13 | ケモセントリックス インコーポレーティッド | 炎症および免疫障害治療用ccr1アンタゴニストとして使用するための1−アリール−4−置換ピペラジン誘導体 |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
AU2003281527A1 (en) * | 2002-07-18 | 2004-02-09 | Pfizer Products Inc. | Bicyclic piperidine derivatives as antagonists of the ccr1 chemokine receptor |
US8261062B2 (en) | 2003-03-27 | 2012-09-04 | Microsoft Corporation | Non-cryptographic addressing |
US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
CA2558211C (en) | 2004-03-03 | 2013-09-03 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US7929689B2 (en) | 2004-06-30 | 2011-04-19 | Microsoft Corporation | Call signs |
GT200500375A (es) * | 2004-12-20 | 2006-11-28 | Derivados de piperidina y su uso como agentes antiinflamatorios | |
US7620902B2 (en) | 2005-04-20 | 2009-11-17 | Microsoft Corporation | Collaboration spaces |
US7617281B2 (en) | 2005-04-25 | 2009-11-10 | Microsoft Corporation | System and method for collaboration with serverless presence |
US7660851B2 (en) | 2005-07-06 | 2010-02-09 | Microsoft Corporation | Meetings near me |
EP1907374B1 (en) | 2005-07-26 | 2012-08-22 | Glaxo Group Limited | Benzylpiperazine derivatives useful for the treatment of gastrointestinal disorders |
US7576106B2 (en) | 2005-10-11 | 2009-08-18 | Chemocentryx, Inc. | Piperidine derivatives and methods of use |
US8069208B2 (en) | 2006-04-21 | 2011-11-29 | Microsoft Corporation | Peer-to-peer buddy request and response |
US8086842B2 (en) | 2006-04-21 | 2011-12-27 | Microsoft Corporation | Peer-to-peer contact exchange |
US8586571B2 (en) * | 2007-10-18 | 2013-11-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
US20100168080A1 (en) * | 2008-12-17 | 2010-07-01 | Khamrai Uttam | Novel compounds useful as cc chemokine receptor ligands |
EP3083596A1 (en) | 2013-12-18 | 2016-10-26 | Basf Se | Azole compounds carrying an imine-derived substituent |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE640616A (es) * | 1962-12-19 | |||
US3492397A (en) * | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
US4060598A (en) * | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
US3538214A (en) * | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
US4173626A (en) * | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
WO1997024325A1 (en) * | 1995-12-28 | 1997-07-10 | Takeda Chemical Industries, Ltd. | DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS |
DK1179341T3 (da) * | 1999-05-18 | 2006-03-27 | Teijin Ltd | Lægemidler eller forebyggende midler mod sygdomme der er associeret med chemokiner |
AR028947A1 (es) * | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
ES2312603T3 (es) * | 2001-07-24 | 2009-03-01 | Richter Gedeon Nyrt | Derivados de piperidina como antagonistas del receptor nmda. |
-
2003
- 2003-06-17 PA PA20038575901A patent/PA8575901A1/es unknown
- 2003-07-07 MX MXPA05000380A patent/MXPA05000380A/es unknown
- 2003-07-07 CA CA002492651A patent/CA2492651A1/en not_active Abandoned
- 2003-07-07 BR BR0312946-2A patent/BR0312946A/pt not_active Application Discontinuation
- 2003-07-07 JP JP2004522601A patent/JP2005537279A/ja active Pending
- 2003-07-07 WO PCT/IB2003/002876 patent/WO2004009550A1/en not_active Application Discontinuation
- 2003-07-07 AU AU2003242941A patent/AU2003242941A1/en not_active Abandoned
- 2003-07-07 AP AP2005003200A patent/AP2005003200A0/xx unknown
- 2003-07-07 OA OA1200500010A patent/OA12885A/en unknown
- 2003-07-07 EP EP03765230A patent/EP1534677A1/en not_active Withdrawn
- 2003-07-07 KR KR10-2005-7000849A patent/KR20050021497A/ko not_active Application Discontinuation
- 2003-07-07 CN CNA038170922A patent/CN1668592A/zh active Pending
- 2003-07-08 US US10/616,844 patent/US20040063759A1/en not_active Abandoned
- 2003-07-15 PE PE2003000705A patent/PE20040666A1/es not_active Application Discontinuation
- 2003-07-16 AR AR20030102555A patent/AR040583A1/es unknown
- 2003-07-16 UY UY27897A patent/UY27897A1/es not_active Application Discontinuation
- 2003-07-17 TW TW092119550A patent/TW200402416A/zh unknown
- 2003-07-17 HN HN2003000222A patent/HN2003000222A/es unknown
-
2004
- 2004-12-23 IS IS7614A patent/IS7614A/is unknown
- 2004-12-27 IL IL16601004A patent/IL166010A0/xx unknown
-
2005
- 2005-01-04 ZA ZA200500067A patent/ZA200500067B/en unknown
- 2005-01-18 MA MA28049A patent/MA27326A1/fr unknown
- 2005-01-18 TN TNP2005000014A patent/TNSN05014A1/fr unknown
- 2005-01-18 EC EC2005005547A patent/ECSP055547A/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW200402416A (en) | 2004-02-16 |
TNSN05014A1 (fr) | 2007-05-14 |
IL166010A0 (en) | 2006-01-15 |
MXPA05000380A (es) | 2005-03-31 |
AR040583A1 (es) | 2005-04-13 |
BR0312946A (pt) | 2005-07-12 |
JP2005537279A (ja) | 2005-12-08 |
ZA200500067B (en) | 2005-11-02 |
IS7614A (is) | 2004-12-23 |
KR20050021497A (ko) | 2005-03-07 |
UY27897A1 (es) | 2004-02-27 |
CA2492651A1 (en) | 2004-01-29 |
EP1534677A1 (en) | 2005-06-01 |
US20040063759A1 (en) | 2004-04-01 |
HN2003000222A (es) | 2004-11-23 |
CN1668592A (zh) | 2005-09-14 |
WO2004009550A1 (en) | 2004-01-29 |
OA12885A (en) | 2006-09-15 |
MA27326A1 (fr) | 2005-05-02 |
AU2003242941A1 (en) | 2004-02-09 |
PE20040666A1 (es) | 2004-09-25 |
AP2005003200A0 (en) | 2005-03-31 |
PA8575901A1 (es) | 2004-07-20 |
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