GT200200095A - Nuevos derivados de acido sulfonico - Google Patents

Nuevos derivados de acido sulfonico

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Publication number
GT200200095A
GT200200095A GT200200095A GT200200095A GT200200095A GT 200200095 A GT200200095 A GT 200200095A GT 200200095 A GT200200095 A GT 200200095A GT 200200095 A GT200200095 A GT 200200095A GT 200200095 A GT200200095 A GT 200200095A
Authority
GT
Guatemala
Prior art keywords
sulfonic acid
new derivatives
affilities
affairs
mip1alfa
Prior art date
Application number
GT200200095A
Other languages
English (en)
Inventor
Matthew Merrill Hayward
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200200095A publication Critical patent/GT200200095A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
  • Molecular Biology (AREA)
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  • Dermatology (AREA)
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  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS DE ACIDO SULFONICO DE FORMULA GENERAL (I) EN DONDE Y,X,A,B,C,R1,R2,R3,R4,R5,SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON POTENTES Y SELECTIVOS INHIBIDORES DE LA UNION DE MIP1ALFA (CCL3) A SU RECEPTOR CCR1, LOCALIZADO EN CELULAS INFLAMATORIAS E INMUNOMODULADORAS (ESPECIALMENTE LEUCOCITOS Y LINFOCITOS) POR LO QUE SON UTILES EN CASOS DE ENFERMEDADES AUTOINMUNES, AFECCIONES INFLAMATORIAS AGUDAS, AFECCIONES ALERGICAS, RECHAZO DE ORGANOS, ENTRE OTROS, CITADOS EN LA SOLICITUD.
GT200200095A 2001-06-20 2002-05-22 Nuevos derivados de acido sulfonico GT200200095A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29946101P 2001-06-20 2001-06-20

Publications (1)

Publication Number Publication Date
GT200200095A true GT200200095A (es) 2003-02-27

Family

ID=23154893

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200200095A GT200200095A (es) 2001-06-20 2002-05-22 Nuevos derivados de acido sulfonico

Country Status (35)

Country Link
US (2) US6974817B2 (es)
EP (1) EP1430041A2 (es)
JP (2) JP3829136B2 (es)
KR (1) KR20040012956A (es)
CN (1) CN1529699A (es)
AP (1) AP1564A (es)
AR (1) AR036094A1 (es)
BG (1) BG108426A (es)
BR (1) BR0210531A (es)
CA (1) CA2447865C (es)
CZ (1) CZ20033455A3 (es)
DO (1) DOP2002000399A (es)
EA (1) EA006447B1 (es)
EC (1) ECSP034917A (es)
EE (1) EE200400023A (es)
GT (1) GT200200095A (es)
HR (1) HRP20030834A2 (es)
HU (1) HUP0400369A2 (es)
IL (1) IL158461A0 (es)
IS (1) IS6987A (es)
MA (1) MA27033A1 (es)
MX (1) MXPA03011954A (es)
NO (1) NO20035694D0 (es)
OA (1) OA12623A (es)
PA (1) PA8548501A1 (es)
PE (1) PE20030127A1 (es)
PL (1) PL366900A1 (es)
SK (1) SK15722003A3 (es)
SV (1) SV2003001099A (es)
TN (1) TNSN03140A1 (es)
UA (1) UA74266C2 (es)
UY (1) UY27338A1 (es)
WO (1) WO2002102787A2 (es)
YU (1) YU94103A (es)
ZA (1) ZA200307736B (es)

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JP3829136B2 (ja) * 2001-06-20 2006-10-04 ファイザー・プロダクツ・インク 新規なスルホン酸誘導体
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
EP1425029A4 (en) * 2001-08-10 2006-06-07 Palatin Technologies Inc PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US20040116441A1 (en) * 2002-10-30 2004-06-17 Pfizer Inc Methods of using sulfonic acid derivatives
JP4736043B2 (ja) 2003-03-14 2011-07-27 小野薬品工業株式会社 含窒素複素環誘導体およびそれらを有効成分とする薬剤
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US20050119275A1 (en) * 2003-06-24 2005-06-02 Pfizer Inc. Salt and crystal forms of (5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-methanesulfonic acid
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
MX2007001215A (es) 2004-08-06 2007-04-17 Otsuka Pharma Co Ltd Compuestos aromaticos.
TWI400232B (zh) 2004-09-13 2013-07-01 Ono Pharmaceutical Co 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑
PL1957073T3 (pl) 2005-12-05 2014-09-30 Otsuka Pharma Co Ltd Substancja lecznicza
AU2007225836A1 (en) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
UA95978C2 (ru) 2006-10-02 2011-09-26 Оцука Фармас'Ютікел Ко., Лтд. Ингибитор активации stat3/5
US8716235B2 (en) * 2012-04-18 2014-05-06 Albert Einstein College Of Medicine Of Yeshiva University Method for inhibiting metastasis by using anti-CCL3 antibodies
FR3029112A1 (fr) * 2014-12-02 2016-06-03 Pf Medicament Dispersion solide a base de derives d'heteroarylsulfonamides a usage pharmaceutique

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JP3829136B2 (ja) * 2001-06-20 2006-10-04 ファイザー・プロダクツ・インク 新規なスルホン酸誘導体

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UA74266C2 (uk) 2005-11-15
JP2005511486A (ja) 2005-04-28
TNSN03140A1 (fr) 2005-12-23
PL366900A1 (en) 2005-02-07
CA2447865C (en) 2010-07-20
EE200400023A (et) 2004-06-15
PA8548501A1 (es) 2003-05-14
US20030083335A1 (en) 2003-05-01
BG108426A (en) 2005-01-31
MA27033A1 (fr) 2004-12-20
IL158461A0 (en) 2004-05-12
PE20030127A1 (es) 2003-02-22
ECSP034917A (es) 2004-02-26
ZA200307736B (en) 2004-10-04
JP3829136B2 (ja) 2006-10-04
CZ20033455A3 (en) 2004-06-16
AP2002002560A0 (en) 2002-06-30
AP1564A (en) 2006-02-02
EP1430041A2 (en) 2004-06-23
SV2003001099A (es) 2003-03-18
DOP2002000399A (es) 2002-12-30
CA2447865A1 (en) 2002-12-27
HUP0400369A2 (hu) 2004-12-28
AR036094A1 (es) 2004-08-11
US20050250790A1 (en) 2005-11-10
UY27338A1 (es) 2003-10-31
EA006447B1 (ru) 2005-12-29
EA200301276A1 (ru) 2004-04-29
JP2006232846A (ja) 2006-09-07
CN1529699A (zh) 2004-09-15
YU94103A (sh) 2006-03-03
MXPA03011954A (es) 2004-03-26
IS6987A (is) 2003-10-09
WO2002102787A3 (en) 2004-04-29
SK15722003A3 (sk) 2004-08-03
NO20035694D0 (no) 2003-12-19
US6974817B2 (en) 2005-12-13
KR20040012956A (ko) 2004-02-11
BR0210531A (pt) 2004-06-22
HRP20030834A2 (en) 2004-08-31
WO2002102787A2 (en) 2002-12-27
OA12623A (en) 2006-06-12

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