OA12602A - Aromatic sulfone hydroxamates and their use as protease inhibitors. - Google Patents

Aromatic sulfone hydroxamates and their use as protease inhibitors. Download PDF

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Publication number
OA12602A
OA12602A OA1200300293A OA1200300293A OA12602A OA 12602 A OA12602 A OA 12602A OA 1200300293 A OA1200300293 A OA 1200300293A OA 1200300293 A OA1200300293 A OA 1200300293A OA 12602 A OA12602 A OA 12602A
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OA
OAPI
Prior art keywords
alkyl
group
alkoxy
substituted
halogen
Prior art date
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OA1200300293A
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English (en)
Inventor
Thomas E Barta
Daniel P Becker
Louis J Bedell
Terri L Boehm
Jeffery N Carroll
Gary A Decrescenzo
Yvette M Fobian
John N Freskos
Susan L Hockerman
Darren J Kassab
Steve A Kolodziej
Joseph J Mcdonald
Deborah A Mischke
Monica B Norton
Joseph G Rico
John J Talley
Clara I Villamil
Lijuan Jane Wang
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Pharmacia Corp
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Publication of OA12602A publication Critical patent/OA12602A/en

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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C04B35/63Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
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    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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OA1200300293A 2001-05-11 2002-05-10 Aromatic sulfone hydroxamates and their use as protease inhibitors. OA12602A (en)

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OA12602A true OA12602A (en) 2006-06-09

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HRP20030901A2 (en) 2005-10-31
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WO2002092588A2 (fr) 2002-11-21
YU85403A (sh) 2006-03-03
WO2002092588A3 (fr) 2003-02-27
KR20040018368A (ko) 2004-03-03
NO20034995L (no) 2003-12-16
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CR7146A (es) 2008-02-11
US6890928B2 (en) 2005-05-10
US20050101641A1 (en) 2005-05-12
AP2003002908A0 (en) 2003-12-31
US6689794B2 (en) 2004-02-10
PL367487A1 (en) 2005-02-21
CA2446586A1 (fr) 2002-11-21
BR0209525A (pt) 2004-03-09
HUP0304069A2 (hu) 2004-04-28
CO5540386A2 (es) 2005-07-29
IS7003A (is) 2003-10-29
NO20034995D0 (no) 2003-11-10
CN1764655A (zh) 2006-04-26

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