OA12532A - Salts of a isothiazole-4-carboxamide and their useas anti-hyperproliferation agents. - Google Patents

Salts of a isothiazole-4-carboxamide and their useas anti-hyperproliferation agents. Download PDF

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Publication number
OA12532A
OA12532A OA1200300137A OA1200300137A OA12532A OA 12532 A OA12532 A OA 12532A OA 1200300137 A OA1200300137 A OA 1200300137A OA 1200300137 A OA1200300137 A OA 1200300137A OA 12532 A OA12532 A OA 12532A
Authority
OA
OAPI
Prior art keywords
sait
isothiazole
bromo
benzyloxy
ureido
Prior art date
Application number
OA1200300137A
Other languages
English (en)
Inventor
Thomas G Gant
Glenn Robert Williams
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of OA12532A publication Critical patent/OA12532A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
OA1200300137A 2000-11-28 2001-11-19 Salts of a isothiazole-4-carboxamide and their useas anti-hyperproliferation agents. OA12532A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25351300P 2000-11-28 2000-11-28

Publications (1)

Publication Number Publication Date
OA12532A true OA12532A (en) 2006-06-02

Family

ID=22960587

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200300137A OA12532A (en) 2000-11-28 2001-11-19 Salts of a isothiazole-4-carboxamide and their useas anti-hyperproliferation agents.

Country Status (50)

Country Link
US (1) US6831091B2 (zh)
EP (1) EP1337521B1 (zh)
JP (2) JP2004514714A (zh)
KR (2) KR20050116401A (zh)
CN (1) CN1231474C (zh)
AP (1) AP2001002358A0 (zh)
AR (1) AR031512A1 (zh)
AT (1) ATE340786T1 (zh)
AU (2) AU2002214204B2 (zh)
BG (1) BG107752A (zh)
BR (1) BR0115621A (zh)
CA (1) CA2430065C (zh)
CR (1) CR6963A (zh)
CY (1) CY1106240T1 (zh)
CZ (1) CZ20031315A3 (zh)
DE (1) DE60123461T2 (zh)
DK (1) DK1337521T3 (zh)
DO (1) DOP2001000288A (zh)
EA (1) EA005859B1 (zh)
EC (1) ECSP034628A (zh)
EE (1) EE200300247A (zh)
ES (1) ES2271086T3 (zh)
GE (1) GEP20053652B (zh)
GT (1) GT200100237A (zh)
HK (1) HK1059085A1 (zh)
HN (1) HN2001000268A (zh)
HR (1) HRP20030408A2 (zh)
HU (1) HUP0302553A3 (zh)
IL (1) IL155371A0 (zh)
IS (1) IS6788A (zh)
MA (1) MA26960A1 (zh)
MX (1) MXPA03004714A (zh)
MY (1) MY136686A (zh)
NO (1) NO325187B1 (zh)
NZ (1) NZ525788A (zh)
OA (1) OA12532A (zh)
PA (1) PA8533801A1 (zh)
PE (1) PE20020591A1 (zh)
PL (1) PL362079A1 (zh)
PT (1) PT1337521E (zh)
SI (1) SI1337521T1 (zh)
SK (1) SK5862003A3 (zh)
SV (1) SV2002000748A (zh)
TN (1) TNSN01167A1 (zh)
TW (1) TWI287542B (zh)
UA (1) UA74221C2 (zh)
UY (1) UY27039A1 (zh)
WO (1) WO2002044158A1 (zh)
YU (1) YU36403A (zh)
ZA (1) ZA200303341B (zh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
JP2002534468A (ja) 1999-01-13 2002-10-15 バイエル コーポレイション ｐ３８キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2003068228A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
AU2003281664A1 (en) * 2002-07-25 2004-02-16 Pfizer Products Inc. Isothiazole derivatives useful as anticancer agents
OA12905A (en) * 2002-08-19 2006-10-13 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
DE602004011340T2 (de) 2003-05-20 2008-11-06 Bayer Healthcare Llc Diaryl-harnstoffe mit kinasehemmender wirkung
ME00294B (me) 2003-07-23 2011-05-10 Bayer Pharmaceuticals Corp Fluoro supstituisana omega-karaboksiaril difenil urea za liječenje i prevenciju bolesti i stanja bolesti
AU2004287416C1 (en) * 2003-10-27 2010-09-09 Merck Sharp & Dohme Corp. CCR-2 antagonist salt
US7572914B2 (en) 2003-12-19 2009-08-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
WO2005102327A1 (en) * 2004-04-20 2005-11-03 Pfizer Products Inc. Dosage forms and methods of treatment using vegfr inhibitors
CN101010315A (zh) 2004-04-30 2007-08-01 拜耳制药公司 用于治疗癌症的取代的吡唑基脲衍生物
TW200538104A (en) * 2004-05-17 2005-12-01 Pfizer Prod Inc Phenyl derivatives for the treatment of abnormal cell growth
EP1778669A2 (en) 2004-08-18 2007-05-02 Takeda San Diego, Inc. Kinase inhibitors
WO2006044687A2 (en) 2004-10-15 2006-04-27 Takeda San Diego, Inc. Kinase inhibitors
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
DK2044043T4 (da) 2006-06-16 2021-04-12 H Lundbeck As 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazinhydrobromid som en forbindelse med kombineret serotoningenoptag, 5-ht3 og 5-ht1a-aktivitet til behandling af kognitiv svækkelse
US7932390B2 (en) 2006-06-29 2011-04-26 Hoffman-La Roche Inc. Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
MX2010001636A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
WO2011073521A1 (en) 2009-12-15 2011-06-23 Petri Salven Methods for enriching adult-derived endothelial progenitor cells and uses thereof
US20130177500A1 (en) 2010-07-23 2013-07-11 Trustee Of Boston University Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
CN111789814B (zh) 2013-03-14 2022-07-19 帕恩欧普佳有限公司 给药于眼后段的眼用制剂
RU2768652C1 (ru) * 2014-09-17 2022-03-24 Паноптика, Инк. Офтальмологические составы для доставки лекарств и защиты переднего отдела глаза

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця

Also Published As

Publication number Publication date
AP2001002358A0 (en) 2001-12-31
CN1476439A (zh) 2004-02-18
AR031512A1 (es) 2003-09-24
BG107752A (bg) 2004-01-30
NO20032388D0 (no) 2003-05-27
KR20050116401A (ko) 2005-12-12
ZA200303341B (en) 2004-04-30
YU36403A (sh) 2006-08-17
ATE340786T1 (de) 2006-10-15
CN1231474C (zh) 2005-12-14
CA2430065A1 (en) 2002-06-06
JP2004514714A (ja) 2004-05-20
JP2008056692A (ja) 2008-03-13
IL155371A0 (en) 2003-11-23
HUP0302553A2 (hu) 2003-11-28
NO325187B1 (no) 2008-02-11
CY1106240T1 (el) 2011-06-08
GT200100237A (es) 2002-07-03
UA74221C2 (uk) 2005-11-15
CR6963A (es) 2003-11-25
UY27039A1 (es) 2002-07-31
GEP20053652B (en) 2005-11-10
BR0115621A (pt) 2003-09-02
PA8533801A1 (es) 2002-10-31
DK1337521T3 (da) 2007-01-29
AU2002214204B2 (en) 2007-05-24
PT1337521E (pt) 2006-12-29
DE60123461D1 (de) 2006-11-09
HK1059085A1 (en) 2004-06-18
CZ20031315A3 (cs) 2004-04-14
SV2002000748A (es) 2002-12-02
HRP20030408A2 (en) 2003-08-31
SK5862003A3 (en) 2004-05-04
TNSN01167A1 (fr) 2005-11-10
EA005859B1 (ru) 2005-06-30
IS6788A (is) 2003-04-14
EE200300247A (et) 2003-10-15
CA2430065C (en) 2008-05-20
PE20020591A1 (es) 2002-07-06
PL362079A1 (en) 2004-10-18
MA26960A1 (fr) 2004-12-20
ES2271086T3 (es) 2007-04-16
EP1337521A1 (en) 2003-08-27
HN2001000268A (es) 2002-01-30
AU1420402A (en) 2002-06-11
SI1337521T1 (sl) 2006-12-31
WO2002044158A1 (en) 2002-06-06
US6831091B2 (en) 2004-12-14
KR20030059275A (ko) 2003-07-07
HUP0302553A3 (en) 2009-03-30
MY136686A (en) 2008-11-28
DE60123461T2 (de) 2007-02-15
MXPA03004714A (es) 2003-08-19
JP4971946B2 (ja) 2012-07-11
NZ525788A (en) 2004-11-26
DOP2001000288A (es) 2002-12-15
EP1337521B1 (en) 2006-09-27
ECSP034628A (es) 2003-07-25
EA200300424A1 (ru) 2003-10-30
US20020151573A1 (en) 2002-10-17
TWI287542B (en) 2007-10-01
NO20032388L (no) 2003-07-18

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