OA11713A - 13-Membered azalides and their use as antibiotic agents. - Google Patents

13-Membered azalides and their use as antibiotic agents. Download PDF

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Publication number
OA11713A
OA11713A OA1200100120A OA1200100120A OA11713A OA 11713 A OA11713 A OA 11713A OA 1200100120 A OA1200100120 A OA 1200100120A OA 1200100120 A OA1200100120 A OA 1200100120A OA 11713 A OA11713 A OA 11713A
Authority
OA
OAPI
Prior art keywords
alkyl
alkenyl
alkynyl
hydrogen
alkenyi
Prior art date
Application number
OA1200100120A
Other languages
English (en)
Inventor
Peter Bertinato
Alan Elwood Blize
John Philip Dirlam
Barry James Morton
Robert John Rafka
Uscolman Brendan Ragan
Uscarl Bernard Ziegler
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22327457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA11713(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of OA11713A publication Critical patent/OA11713A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
OA1200100120A 1998-11-20 1999-11-09 13-Membered azalides and their use as antibiotic agents. OA11713A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10939998P 1998-11-20 1998-11-20

Publications (1)

Publication Number Publication Date
OA11713A true OA11713A (en) 2005-01-25

Family

ID=22327457

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200100120A OA11713A (en) 1998-11-20 1999-11-09 13-Membered azalides and their use as antibiotic agents.

Country Status (46)

Country Link
US (1) US6329345B1 (uk)
EP (1) EP1131331B1 (uk)
JP (1) JP3842973B2 (uk)
KR (1) KR100477774B1 (uk)
CN (2) CN101367853A (uk)
AP (1) AP2001002142A0 (uk)
AR (3) AR019496A1 (uk)
AT (1) ATE260927T1 (uk)
AU (1) AU766106B2 (uk)
BG (1) BG65107B1 (uk)
BR (2) BRPI9915480B1 (uk)
CA (1) CA2351429C (uk)
CO (1) CO5380019A1 (uk)
CZ (1) CZ303099B6 (uk)
DE (1) DE69915336T2 (uk)
DK (1) DK1131331T3 (uk)
DZ (1) DZ2944A1 (uk)
EA (2) EA005156B1 (uk)
EG (1) EG23823A (uk)
ES (1) ES2216581T3 (uk)
GT (1) GT199900198A (uk)
HK (1) HK1041269A1 (uk)
HR (1) HRP20010374B1 (uk)
HU (1) HU229008B1 (uk)
ID (1) ID28548A (uk)
IL (3) IL142631A0 (uk)
IS (1) IS2350B (uk)
MA (1) MA26707A1 (uk)
ME (1) ME00467B (uk)
MY (1) MY122353A (uk)
NO (3) NO319796B1 (uk)
NZ (1) NZ511199A (uk)
OA (1) OA11713A (uk)
PA (1) PA8485601A1 (uk)
PE (1) PE20001378A1 (uk)
PL (1) PL198580B1 (uk)
PT (1) PT1131331E (uk)
RS (1) RS50302B (uk)
SI (1) SI1131331T1 (uk)
SK (1) SK284607B6 (uk)
TN (1) TNSN99214A1 (uk)
TW (2) TWI243825B (uk)
UA (1) UA70972C2 (uk)
UY (1) UY25805A1 (uk)
WO (1) WO2000031097A1 (uk)
ZA (1) ZA200104019B (uk)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
AU3832100A (en) * 1999-05-24 2000-12-12 Pfizer Products Inc. 13-methyl-erythromycin derivatives
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
PL359861A1 (en) * 2000-04-27 2004-09-06 Pfizer Products Inc. The use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals
RU2263117C2 (ru) * 2001-04-27 2005-10-27 Пфайзер Продактс Инк. Способ получения 4"-замещенных производных 9-деоксо-9а-аза-9а-гомоэритромицина а
WO2003014136A1 (en) * 2001-08-08 2003-02-20 Taisho Pharmaceutical Co., Ltd. 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
CA2801100A1 (en) * 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Macrolides and processes for their preparation
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
CA2546195A1 (en) * 2003-11-21 2005-06-02 Pfizer Products Inc. The use of anti biotics as vaccine adjuvants
JP5015016B2 (ja) * 2006-02-07 2012-08-29 大正製薬株式会社 １０ａ−アザライド化合物
EP2177526A4 (en) * 2007-08-06 2012-08-22 Taisho Pharmaceutical Co Ltd 10A-AZALIDE COMPOUND CROSS-LINKED IN POSITION 10A AND POSITION 12
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
JP5908479B2 (ja) * 2010-09-20 2016-04-26 ノバルティス ティーアゲズントハイト アーゲー クラジノース環のＣ−４”をエポキシド基で修飾した９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシンＡの新規製造方法
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
SI3027634T1 (sl) * 2013-07-31 2018-10-30 Farma Grs, D.O.O. Proces za pripravo tulatromicina
CN109748942A (zh) * 2014-05-16 2019-05-14 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
JP2022507795A (ja) * 2018-11-19 2022-01-18 ジカニ セラピューティクス， インコーポレイテッド Ｃ１０環状置換１３員マクロライド及びそれらの使用
CN113573779A (zh) * 2018-11-19 2021-10-29 齐卡尼治疗股份有限公司 C10-亚烷基取代的13元大环内酯及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
YU44599B (en) * 1986-09-12 1990-10-31 Pliva Pharm & Chem Works Process for preparing complex of n-methyl-11-aza-10-deoxo-10-dihydroeritromicine a and 11-aza-10-deoxo-10-dihydroeritromicine a with metals
US5106961A (en) 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
SI9011409A (en) 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
GB2327084A (en) * 1997-07-08 1999-01-13 Merck & Co Inc 9a-Aza-3-ketolide antibiotics
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
RS50302B (sr) 2009-09-08
CA2351429C (en) 2005-07-12
BG65107B1 (bg) 2007-02-28
IS2350B (is) 2008-04-15
BR9915480A (pt) 2001-07-31
IS5918A (is) 2001-04-17
PL198580B1 (pl) 2008-06-30
NO329629B1 (no) 2010-11-22
PA8485601A1 (es) 2000-09-29
ME00467B (me) 2011-10-10
KR100477774B1 (ko) 2005-03-21
HRP20010374A2 (en) 2002-06-30
NO20012464L (no) 2001-07-17
JP2002530422A (ja) 2002-09-17
ATE260927T1 (de) 2004-03-15
PT1131331E (pt) 2004-06-30
MA26707A1 (fr) 2004-12-20
EP1131331B1 (en) 2004-03-03
NZ511199A (en) 2003-08-29
NO20050904L (no) 2001-07-17
TWI243824B (en) 2005-11-21
IL142631A0 (en) 2002-03-10
SK284607B6 (sk) 2005-07-01
HUP0104313A3 (en) 2003-12-29
ZA200104019B (en) 2002-06-17
EA200100416A1 (ru) 2001-10-22
DK1131331T3 (da) 2004-06-14
NO20012464D0 (no) 2001-05-18
KR20010086043A (ko) 2001-09-07
NO330249B1 (no) 2011-03-14
IL189430A0 (en) 2008-06-05
BRPI9915480B1 (pt) 2015-12-29
ES2216581T3 (es) 2004-10-16
CN1326460A (zh) 2001-12-12
AP2001002142A0 (en) 2001-05-09
UA70972C2 (uk) 2004-11-15
AR059524A2 (es) 2008-04-09
DE69915336D1 (de) 2004-04-08
TNSN99214A1 (fr) 2005-11-10
TWI243825B (en) 2005-11-21
CA2351429A1 (en) 2000-06-02
TW200404077A (en) 2004-03-16
AR059523A2 (es) 2008-04-09
PE20001378A1 (es) 2000-12-14
DE69915336T2 (de) 2005-01-13
NO319796B1 (no) 2005-09-19
SK6632001A3 (en) 2002-07-02
ID28548A (id) 2001-05-31
CZ303099B6 (cs) 2012-04-04
CO5380019A1 (es) 2004-03-31
GT199900198A (es) 2001-05-11
YU33401A (sh) 2004-05-12
EA005156B1 (ru) 2004-12-30
EA009729B1 (ru) 2008-02-28
BRPI9915480B8 (pt) 2022-05-10
HU229008B1 (en) 2013-07-29
AR019496A1 (es) 2002-02-20
MY122353A (en) 2006-04-29
IL142631A (en) 2010-05-31
CZ20011754A3 (cs) 2002-03-13
EG23823A (en) 2007-09-19
NO20050893L (no) 2001-07-17
BG105600A (en) 2001-12-29
EP1131331A1 (en) 2001-09-12
WO2000031097A1 (en) 2000-06-02
PL347784A1 (en) 2002-04-22
UY25805A1 (es) 2001-08-27
AU1068600A (en) 2000-06-13
SI1131331T1 (en) 2004-08-31
JP3842973B2 (ja) 2006-11-08
HUP0104313A2 (hu) 2002-02-28
EA200400701A1 (ru) 2004-12-30
IL189430A (en) 2010-05-31
HRP20010374B1 (en) 2006-09-30
CN101367853A (zh) 2009-02-18
AU766106B2 (en) 2003-10-09
HK1041269A1 (zh) 2002-07-05
US6329345B1 (en) 2001-12-11
DZ2944A1 (fr) 2004-03-15

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