OA11094A - Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration - Google Patents

Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration Download PDF

Info

Publication number
OA11094A
OA11094A OA9800077A OA9800077A OA11094A OA 11094 A OA11094 A OA 11094A OA 9800077 A OA9800077 A OA 9800077A OA 9800077 A OA9800077 A OA 9800077A OA 11094 A OA11094 A OA 11094A
Authority
OA
OAPI
Prior art keywords
group
hydrogen
process according
alkyl
formula
Prior art date
Application number
OA9800077A
Other languages
English (en)
Inventor
Tarek Mansour
Alex Cimpoia
Bednarski Krzysztof
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of OA11094A publication Critical patent/OA11094A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
OA9800077A 1995-12-14 1998-06-09 Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration OA11094A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration

Publications (1)

Publication Number Publication Date
OA11094A true OA11094A (en) 2003-03-13

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9800077A OA11094A (en) 1995-12-14 1998-06-09 Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration

Country Status (27)

Country Link
US (4) US5922867A (forum.php)
EP (1) EP0970074B1 (forum.php)
JP (1) JP3229990B2 (forum.php)
KR (1) KR100406159B1 (forum.php)
CN (1) CN1080263C (forum.php)
AP (1) AP879A (forum.php)
AT (1) ATE214699T1 (forum.php)
AU (1) AU706328B2 (forum.php)
BR (1) BR9612351A (forum.php)
CA (1) CA2237730C (forum.php)
DE (1) DE69620042T2 (forum.php)
DK (1) DK0970074T3 (forum.php)
EA (1) EA000844B1 (forum.php)
ES (1) ES2172697T3 (forum.php)
GB (1) GB9525606D0 (forum.php)
HU (1) HU224076B1 (forum.php)
IL (3) IL124663A (forum.php)
IN (1) IN187349B (forum.php)
MX (1) MX9804701A (forum.php)
NO (1) NO309901B1 (forum.php)
NZ (1) NZ323855A (forum.php)
OA (1) OA11094A (forum.php)
PL (1) PL188447B1 (forum.php)
PT (1) PT970074E (forum.php)
TW (1) TW341574B (forum.php)
WO (1) WO1997021706A1 (forum.php)
ZA (1) ZA9610544B (forum.php)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6898498A (en) 1997-04-07 1998-10-30 Triangle Pharmaceuticals, Inc. Use of mkc-442 in combination with other antiviral agents
KR100856416B1 (ko) 1998-08-12 2008-09-04 길리애드 사이언시즈, 인코포레이티드 1,3-옥사티올란 뉴클레오시드의 제조 방법
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
OA11741A (en) * 1998-12-23 2005-05-13 Iaf Biochem Int Antiviral nucleoside analogues.
EP1151133A1 (en) * 1999-02-11 2001-11-07 McGILL UNIVERSITY Stereoselective synthesis of nucleoside analogues
ES2218216T3 (es) * 1999-09-24 2004-11-16 Shire Biochem Inc. Analogos de nucleosidos de dioxolano para el tratamiento o la prevencion de infecciones viricas.
EP1225899A2 (en) 1999-11-04 2002-07-31 Virochem Pharma Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
ATE397001T1 (de) * 2000-02-10 2008-06-15 Mitsui Chemicals Inc Verfahren zur selektiven herstellung eines 1- phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden
JP2003522769A (ja) * 2000-02-11 2003-07-29 シェア バイオケム インコーポレーテッド ヌクレオシド類似体の立体選択的合成
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
CA2867970A1 (en) * 2001-03-01 2002-09-12 Gilead Sciences, Inc. Polymorphic and other crystalline forms of cis-ftc
WO2003020222A2 (en) * 2001-09-04 2003-03-13 Merck & Co., Inc. PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE
CA2465682A1 (en) * 2001-11-02 2003-05-08 Shire Biochem Inc. Methods of treating leukemia
EP1569652A4 (en) * 2001-12-14 2008-07-02 Pharmasset Inc NUCLEOSIDES N SP 4 / SP-ACYLCYTOSINES FOR THE TREATMENT OF VIRAL INFECTIONS
JP4441265B2 (ja) 2002-01-25 2010-03-31 シャー バイオケム インコーポレイティッド ジオキソランヌクレオシド類似体の製造方法
BR0313302A (pt) 2002-08-06 2005-06-28 Pharmasset Inc Processos para a preparação de nucleosìdeos de 1,3-dioxolano
WO2004046214A2 (en) 2002-10-15 2004-06-03 Exxonmobil Chemical Patents Inc. Multiple catalyst system for olefin polymerization and polymers produced therefrom
DE10335061B4 (de) * 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
EP1720840B1 (en) 2004-02-03 2016-02-03 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
JP7337539B2 (ja) * 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
IL106078A0 (en) * 1992-06-22 1993-10-20 Lilly Co Eli Stereoselective anion glycosylation process

Also Published As

Publication number Publication date
HK1017886A1 (en) 1999-12-03
ZA9610544B (en) 1997-07-29
AU706328B2 (en) 1999-06-17
IL144155A0 (en) 2002-05-23
AP9801252A0 (en) 1998-06-30
NZ323855A (en) 1999-11-29
CA2237730C (en) 2001-12-04
HUP9901050A2 (hu) 2001-04-28
JP3229990B2 (ja) 2001-11-19
EA199800555A1 (ru) 1999-02-25
US6069250A (en) 2000-05-30
US20030060476A1 (en) 2003-03-27
PL188447B1 (pl) 2005-02-28
IL144155A (en) 2003-07-06
IL124663A (en) 2001-10-31
BR9612351A (pt) 1999-07-13
DK0970074T3 (da) 2002-07-15
JP2000501714A (ja) 2000-02-15
IL124663A0 (en) 1998-12-06
NO982716D0 (no) 1998-06-12
AP879A (en) 2000-10-02
EP0970074B1 (en) 2002-03-20
PT970074E (pt) 2002-09-30
ATE214699T1 (de) 2002-04-15
CA2237730A1 (en) 1997-06-19
HUP9901050A3 (en) 2001-05-28
DE69620042T2 (de) 2002-10-17
US5922867A (en) 1999-07-13
NO982716L (no) 1998-06-12
KR19990072141A (ko) 1999-09-27
CN1080263C (zh) 2002-03-06
NO309901B1 (no) 2001-04-17
GB9525606D0 (en) 1996-02-14
DE69620042D1 (de) 2002-04-25
EA000844B1 (ru) 2000-06-26
MX9804701A (es) 1998-10-31
HU224076B1 (hu) 2005-05-30
CN1208414A (zh) 1999-02-17
ES2172697T3 (es) 2002-10-01
US20020058670A1 (en) 2002-05-16
EP0970074A1 (en) 2000-01-12
KR100406159B1 (ko) 2004-11-16
IN187349B (forum.php) 2002-03-30
PL327443A1 (en) 1998-12-07
TW341574B (en) 1998-10-01
AU1089397A (en) 1997-07-03
WO1997021706A1 (en) 1997-06-19

Similar Documents

Publication Publication Date Title
OA11094A (en) Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration
KR0160144B1 (ko) 뉴클레오시드의 부분 입체 이성체를 선택적으로 합성하는 방법
HU218044B (hu) Eljárás nukleozid analógok diasztereoszelektív szintézisére, valamint az eljárással előállított vegyületek szalicilátsói és ezek hidrátjai
FI112078B (fi) Nukleosidianalogien stereoselektiivinen synteesi kaksirenkaista välituotetta käyttämällä
KR101108115B1 (ko) 1,3-디옥솔란 뉴클레오사이드의 제조 방법
EP1632490A1 (en) Stereoselective method for the preparation of nucleoside analogues
HK1017886B (en) METHOD AND INTERMEDIATE FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDE WITH β-CONFIGURATION
CN1222157A (zh) 高收率非对映选择性合成二脱氧核苷的方法
HK1008673B (en) Stereoselective synthesis of nucleoside analogues using bicyclic intermediate