OA11094A - Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration - Google Patents

Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration Download PDF

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Publication number
OA11094A
OA11094A OA9800077A OA9800077A OA11094A OA 11094 A OA11094 A OA 11094A OA 9800077 A OA9800077 A OA 9800077A OA 9800077 A OA9800077 A OA 9800077A OA 11094 A OA11094 A OA 11094A
Authority
OA
OAPI
Prior art keywords
group
hydrogen
process according
alkyl
formula
Prior art date
Application number
OA9800077A
Other languages
English (en)
Inventor
Tarek Mansour
Alex Cimpoia
Bednarski Krzysztof
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of OA11094A publication Critical patent/OA11094A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
OA9800077A 1995-12-14 1998-06-09 Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration OA11094A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration

Publications (1)

Publication Number Publication Date
OA11094A true OA11094A (en) 2003-03-13

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9800077A OA11094A (en) 1995-12-14 1998-06-09 Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration

Country Status (27)

Country Link
US (4) US5922867A (fa)
EP (1) EP0970074B1 (fa)
JP (1) JP3229990B2 (fa)
KR (1) KR100406159B1 (fa)
CN (1) CN1080263C (fa)
AP (1) AP879A (fa)
AT (1) ATE214699T1 (fa)
AU (1) AU706328B2 (fa)
BR (1) BR9612351A (fa)
CA (1) CA2237730C (fa)
DE (1) DE69620042T2 (fa)
DK (1) DK0970074T3 (fa)
EA (1) EA000844B1 (fa)
ES (1) ES2172697T3 (fa)
GB (1) GB9525606D0 (fa)
HU (1) HU224076B1 (fa)
IL (3) IL124663A (fa)
IN (1) IN187349B (fa)
MX (1) MX9804701A (fa)
NO (1) NO309901B1 (fa)
NZ (1) NZ323855A (fa)
OA (1) OA11094A (fa)
PL (1) PL188447B1 (fa)
PT (1) PT970074E (fa)
TW (1) TW341574B (fa)
WO (1) WO1997021706A1 (fa)
ZA (1) ZA9610544B (fa)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001518899A (ja) 1997-04-07 2001-10-16 トライアングル ファーマシューティカルズ，インコーポレイティド 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用
JP4249393B2 (ja) 1998-08-12 2009-04-02 トライアングル・ファーマシューティカルズ，インコーポレイテッド １，３−オキサチオランヌクレオチドの製造方法
US6979561B1 (en) * 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
EP1140937B1 (en) 1998-12-23 2003-11-12 Shire Biochem Inc. Antiviral nucleoside analogues
EP1151133A1 (en) * 1999-02-11 2001-11-07 McGILL UNIVERSITY Stereoselective synthesis of nucleoside analogues
EP1214074B1 (en) * 1999-09-24 2004-06-16 Shire Biochem Inc. Dioxolane nucleoside analogs for the treatment or prevention of viral infection
US6566365B1 (en) 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
WO2001058920A2 (en) * 2000-02-10 2001-08-16 Mitsui Chemicals, Inc. Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
WO2001058894A1 (en) * 2000-02-11 2001-08-16 Shire Biochem Inc. Stereoselective synthesis of nucleoside analogues
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
CA2788498C (en) * 2001-03-01 2016-02-16 Gilead Sciences, Inc. Polymorphic and other crystalline forms of cis-ftc
AU2002329970A1 (en) * 2001-09-04 2003-03-18 Isis Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
JP2005512984A (ja) * 2001-11-02 2005-05-12 シャイアー バイオケム インコーポレイテッド ジオキソランヌクレオシド類似体を含む白血病の治療のための医薬組成物
MXPA04005779A (es) 2001-12-14 2005-05-16 Pharmasset Ltd Nucleosidos de n4-acilcitosina para el tratamiento de infecciones virales.
JP4441265B2 (ja) 2002-01-25 2010-03-31 シャー バイオケム インコーポレイティッド ジオキソランヌクレオシド類似体の製造方法
EP1534255B1 (en) 2002-08-06 2011-01-19 Pharmasset, Inc. Processes for preparing 1,3-dioxolane nucleosides
EP1620479B1 (en) 2002-10-15 2013-07-24 ExxonMobil Chemical Patents Inc. Polyolefin adhesive compositions and articles made therefrom
DE10335061B4 (de) * 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
CN101044122A (zh) * 2004-02-03 2007-09-26 埃莫里大学 制备1,3－二氧戊环核苷的方法
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
JP7337539B2 (ja) 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
CN1086519A (zh) * 1992-06-22 1994-05-11 伊莱利利公司 立体有择阴离子糖基化方法

Also Published As

Publication number Publication date
AU1089397A (en) 1997-07-03
ATE214699T1 (de) 2002-04-15
GB9525606D0 (en) 1996-02-14
JP2000501714A (ja) 2000-02-15
MX9804701A (es) 1998-10-31
DE69620042T2 (de) 2002-10-17
EA000844B1 (ru) 2000-06-26
IL124663A (en) 2001-10-31
HK1017886A1 (en) 1999-12-03
AP879A (en) 2000-10-02
US5922867A (en) 1999-07-13
PL188447B1 (pl) 2005-02-28
HUP9901050A2 (hu) 2001-04-28
EP0970074B1 (en) 2002-03-20
US6069250A (en) 2000-05-30
CA2237730A1 (en) 1997-06-19
CN1208414A (zh) 1999-02-17
IL144155A0 (en) 2002-05-23
BR9612351A (pt) 1999-07-13
JP3229990B2 (ja) 2001-11-19
EP0970074A1 (en) 2000-01-12
IL144155A (en) 2003-07-06
HU224076B1 (hu) 2005-05-30
US20030060476A1 (en) 2003-03-27
TW341574B (en) 1998-10-01
ZA9610544B (en) 1997-07-29
NZ323855A (en) 1999-11-29
ES2172697T3 (es) 2002-10-01
CA2237730C (en) 2001-12-04
DK0970074T3 (da) 2002-07-15
IN187349B (fa) 2002-03-30
PT970074E (pt) 2002-09-30
HUP9901050A3 (en) 2001-05-28
NO982716L (no) 1998-06-12
KR19990072141A (ko) 1999-09-27
US20020058670A1 (en) 2002-05-16
EA199800555A1 (ru) 1999-02-25
KR100406159B1 (ko) 2004-11-16
IL124663A0 (en) 1998-12-06
WO1997021706A1 (en) 1997-06-19
NO982716D0 (no) 1998-06-12
CN1080263C (zh) 2002-03-06
AP9801252A0 (en) 1998-06-30
AU706328B2 (en) 1999-06-17
NO309901B1 (no) 2001-04-17
DE69620042D1 (de) 2002-04-25
PL327443A1 (en) 1998-12-07

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